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Protein

Neurogenic locus protein delta

Gene

Dl

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a ligand for Notch (N) receptor. Essential for proper differentiation of ectoderm. Dl is required for the correct separation of neural and epidermal cell lineages. Fringe (fng) acts in the Golgi to determine the type of O-linked fucose on the EGF modules in N, altering the ability of N to bind with Delta (Dl). O-fut1 also has a role in modulating the interaction.1 Publication

Miscellaneous

Separation of neuroblasts from the ectoderm into the inner part of embryo is one of the first steps of CNS development in insects, this process is under control of the neurogenic genes.
Notch and Serrate may interact at the protein level, it is conceivable that the Serrate and Delta proteins may compete for binding with the Notch protein.

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • Notch binding Source: FlyBase
  • signaling receptor binding Source: FlyBase

GO - Biological processi

  • actin filament organization Source: FlyBase
  • antennal morphogenesis Source: FlyBase
  • apposition of dorsal and ventral imaginal disc-derived wing surfaces Source: FlyBase
  • asymmetric cell division Source: FlyBase
  • border follicle cell migration Source: FlyBase
  • cell adhesion Source: FlyBase
  • cell fate specification Source: FlyBase
  • chaeta morphogenesis Source: FlyBase
  • compound eye cone cell fate commitment Source: FlyBase
  • compound eye development Source: FlyBase
  • compound eye retinal cell programmed cell death Source: FlyBase
  • dorsal/ventral lineage restriction, imaginal disc Source: FlyBase
  • ectoderm development Source: FlyBase
  • establishment of ommatidial planar polarity Source: FlyBase
  • establishment of planar polarity Source: FlyBase
  • germ-line stem cell population maintenance Source: FlyBase
  • glial cell migration Source: FlyBase
  • imaginal disc-derived leg morphogenesis Source: FlyBase
  • imaginal disc-derived leg segmentation Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • imaginal disc-derived wing vein morphogenesis Source: FlyBase
  • imaginal disc-derived wing vein specification Source: FlyBase
  • lateral inhibition Source: FlyBase
  • mesoderm development Source: FlyBase
  • negative regulation of fusion cell fate specification Source: FlyBase
  • negative regulation of neurogenesis Source: FlyBase
  • negative regulation of terminal cell fate specification, open tracheal system Source: FlyBase
  • nervous system development Source: FlyBase
  • Notch signaling pathway Source: FlyBase
  • oocyte anterior/posterior axis specification Source: FlyBase
  • oocyte localization involved in germarium-derived egg chamber formation Source: FlyBase
  • oogenesis Source: FlyBase
  • open tracheal system development Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • ovarian follicle cell stalk formation Source: FlyBase
  • peripheral nervous system development Source: FlyBase
  • positive regulation of cell proliferation Source: FlyBase
  • positive regulation of mitotic cell cycle Source: FlyBase
  • R3/R4 cell fate commitment Source: FlyBase
  • R8 cell differentiation Source: FlyBase
  • R8 cell fate commitment Source: FlyBase
  • regulation of R8 cell spacing in compound eye Source: FlyBase
  • second mitotic wave involved in compound eye morphogenesis Source: FlyBase
  • sensory organ development Source: FlyBase
  • stem cell differentiation Source: FlyBase
  • ventral cord development Source: FlyBase
  • wing disc dorsal/ventral pattern formation Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis, Notch signaling pathway

Enzyme and pathway databases

ReactomeiR-DME-1980150 Signaling by NOTCH4
R-DME-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus
R-DME-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus
SignaLinkiP10041

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenic locus protein delta
Gene namesi
Name:Dl
ORF Names:CG3619
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0000463 Dl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 594ExtracellularSequence analysisAdd BLAST576
Transmembranei595 – 617HelicalSequence analysisAdd BLAST23
Topological domaini618 – 833CytoplasmicSequence analysisAdd BLAST216

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000750519 – 833Neurogenic locus protein deltaAdd BLAST815

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 61By similarity
Disulfide bondi68 ↔ 82By similarity
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi184 ↔ 193PROSITE-ProRule annotationBy similarity
Disulfide bondi197 ↔ 209PROSITE-ProRule annotationBy similarity
Disulfide bondi217 ↔ 226PROSITE-ProRule annotationBy similarity
Disulfide bondi231 ↔ 240PROSITE-ProRule annotationBy similarity
Disulfide bondi235 ↔ 246PROSITE-ProRule annotationBy similarity
Disulfide bondi248 ↔ 257PROSITE-ProRule annotationBy similarity
Disulfide bondi260 ↔ 271By similarity
Disulfide bondi266 ↔ 277By similarity
Disulfide bondi279 ↔ 288PROSITE-ProRule annotationBy similarity
Disulfide bondi295 ↔ 307By similarity
Disulfide bondi301 ↔ 317By similarity
Disulfide bondi319 ↔ 328By similarity
Disulfide bondi335 ↔ 348By similarity
Disulfide bondi342 ↔ 360By similarity
Disulfide bondi362 ↔ 371By similarity
Disulfide bondi378 ↔ 388By similarity
Disulfide bondi383 ↔ 404By similarity
Disulfide bondi406 ↔ 415By similarity
Disulfide bondi422 ↔ 433By similarity
Disulfide bondi427 ↔ 439By similarity
Disulfide bondi441 ↔ 450By similarity
Disulfide bondi457 ↔ 468By similarity
Disulfide bondi462 ↔ 477By similarity
Disulfide bondi479 ↔ 488By similarity
Disulfide bondi495 ↔ 506By similarity
Disulfide bondi500 ↔ 515By similarity
Disulfide bondi517 ↔ 526By similarity
Disulfide bondi533 ↔ 544By similarity
Disulfide bondi538 ↔ 553By similarity
Disulfide bondi555 ↔ 564By similarity
Modified residuei666Phosphothreonine1 Publication1

Post-translational modificationi

Ubiquitinated by Mib, leading to its endocytosis and subsequent degradation.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP10041
PRIDEiP10041

PTM databases

iPTMnetiP10041

Miscellaneous databases

PMAP-CutDBiP10041

Expressioni

Tissue specificityi

Detected in all areas with neurogenic abilities, for example the neurogenic ectoderm and the primordia of the sense organs. Later expression is restricted to those cells that have adopted a neural fate.1 Publication

Developmental stagei

Expressed both maternally and zygotically. Expression is highest early in embryonic development (stage 5) and reduces to a low level during larval stages.1 Publication

Gene expression databases

BgeeiFBgn0000463
ExpressionAtlasiP10041 baseline and differential
GenevisibleiP10041 DM

Interactioni

Subunit structurei

Interacts with N via the EGF repeats and the N EGF repeats.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NP072072EBI-115346,EBI-103438

GO - Molecular functioni

  • Notch binding Source: FlyBase
  • signaling receptor binding Source: FlyBase

Protein-protein interaction databases

BioGridi67310, 119 interactors
DIPiDIP-22726N
IntActiP10041, 2 interactors
STRINGi7227.FBpp0083153

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XIBX-ray2.15C680-690[»]
ProteinModelPortaliP10041
SMRiP10041
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 226DSLPROSITE-ProRule annotationAdd BLAST45
Domaini227 – 258EGF-like 1PROSITE-ProRule annotationAdd BLAST32
Domaini256 – 289EGF-like 2PROSITE-ProRule annotationAdd BLAST34
Domaini291 – 329EGF-like 3PROSITE-ProRule annotationAdd BLAST39
Domaini331 – 372EGF-like 4PROSITE-ProRule annotationAdd BLAST42
Domaini374 – 416EGF-like 5PROSITE-ProRule annotationAdd BLAST43
Domaini418 – 451EGF-like 6PROSITE-ProRule annotationAdd BLAST34
Domaini453 – 489EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini491 – 527EGF-like 8PROSITE-ProRule annotationAdd BLAST37
Domaini529 – 565EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR7B Eukaryota
ENOG410XUNS LUCA
GeneTreeiENSGT00810000125346
InParanoidiP10041
KOiK06051
OMAiDKPCHQG
OrthoDBiEOG091G07YQ
PhylomeDBiP10041

Family and domain databases

InterProiView protein in InterPro
IPR001774 DSL
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR011651 Notch_ligand_N
PfamiView protein in Pfam
PF01414 DSL, 1 hit
PF00008 EGF, 6 hits
PF12661 hEGF, 1 hit
PF07657 MNNL, 1 hit
SMARTiView protein in SMART
SM00051 DSL, 1 hit
SM00181 EGF, 9 hits
SM00179 EGF_CA, 7 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS51051 DSL, 1 hit
PS00022 EGF_1, 9 hits
PS01186 EGF_2, 9 hits
PS50026 EGF_3, 7 hits
PS01187 EGF_CA, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10041-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHWIKCLLTA FICFTVIVQV HSSGSFELRL KYFSNDHGRD NEGRCCSGES
60 70 80 90 100
DGATGKCLGS CKTRFRVCLK HYQATIDTTS QCTYGDVITP ILGENSVNLT
110 120 130 140 150
DAQRFQNKGF TNPIQFPFSF SWPGTFSLIV EAWHDTNNSG NARTNKLLIQ
160 170 180 190 200
RLLVQQVLEV SSEWKTNKSE SQYTSLEYDF RVTCDLNYYG SGCAKFCRPR
210 220 230 240 250
DDSFGHSTCS ETGEIICLTG WQGDYCHIPK CAKGCEHGHC DKPNQCVCQL
260 270 280 290 300
GWKGALCNEC VLEPNCIHGT CNKPWTCICN EGWGGLYCNQ DLNYCTNHRP
310 320 330 340 350
CKNGGTCFNT GEGLYTCKCA PGYSGDDCEN EIYSCDADVN PCQNGGTCID
360 370 380 390 400
EPHTKTGYKC HCANGWSGKM CEEKVLTCSD KPCHQGICRN VRPGLGSKGQ
410 420 430 440 450
GYQCECPIGY SGPNCDLQLD NCSPNPCING GSCQPSGKCI CPAGFSGTRC
460 470 480 490 500
ETNIDDCLGH QCENGGTCID MVNQYRCQCV PGFHGTHCSS KVDLCLIRPC
510 520 530 540 550
ANGGTCLNLN NDYQCTCRAG FTGKDCSVDI DECSSGPCHN GGTCMNRVNS
560 570 580 590 600
FECVCANGFR GKQCDEESYD SVTFDAHQYG ATTQARADGL TNAQVVLIAV
610 620 630 640 650
FSVAMPLVAV IAACVVFCMK RKRKRAQEKD DAEARKQNEQ NAVATMHHNG
660 670 680 690 700
SGVGVALASA SLGGKTGSNS GLTFDGGNPN IIKNTWDKSV NNICASAAAA
710 720 730 740 750
AAAAAAADEC LMYGGYVASV ADNNNANSDF CVAPLQRAKS QKQLNTDPTL
760 770 780 790 800
MHRGSPAGSS AKGASGGGPG AAEGKRISVL GEGSYCSQRW PSLAAAGVAG
810 820 830
ACSSQLMAAA SVAGSGAGTA QQQRSVVCGT PHM
Length:833
Mass (Da):88,841
Last modified:December 1, 2000 - v2
Checksum:iEDBA107A0003D9A1
GO

Sequence cautioni

The sequence AAL28817 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti437 – 438GK → ET in CAA28786 (PubMed:3107986).Curated2
Sequence conflicti443A → S in CAA28786 (PubMed:3107986).Curated1
Sequence conflicti459G → A in CAA28786 (PubMed:3107986).Curated1
Sequence conflicti490S → T in CAA28786 (PubMed:3107986).Curated1
Sequence conflicti591T → A in CAA28786 (PubMed:3107986).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti398K → R in strain: sonoma_017. 1
Natural varianti443A → T in strain: sonoma_009, sonoma_051, sonoma_053 and sonoma_054. 1
Natural varianti461Q → K in strain: sonoma_010, sonoma_013, sonoma_019 and sonoma_117. 1
Natural varianti652G → A in strain: NapaValley5, NapaValley12, sonoma_015, sonoma_016, sonoma_023, sonoma_032, sonoma_034, sonoma_038, sonoma_040, sonoma_045, sonoma_048, sonoma_050, sonoma_061, sonoma_073, sonoma_081, sonoma_085, sonoma_094, sonoma_097 and sonoma_119. 1 Publication1
Natural varianti662L → M in strain: sonoma_008, sonoma_015, sonoma_016, sonoma_032, sonoma_034, sonoma_038, sonoma_040, sonoma_045, sonoma_048, sonoma_050, sonoma_061, sonoma_073, sonoma_081, sonoma_085, sonoma_094 and sonoma_097. 1 Publication1
Natural varianti761A → T in strain: sonoma_006, sonoma_022 and sonoma_040. 1
Natural varianti787S → G in strain: nps_6, nps_18, nps_34, sonoma_048 and sonoma_050. 1
Natural varianti800G → R in strain: sonoma_002. 1
Natural varianti812V → A in strain: nps_19, nps_21, nps_25, nps_26, nps_27, nps_30, nps_31, nps_33, nps_35, nps_42, nps_43, nps_45, nps_47, sonoma_002, sonoma_003, sonoma_004, sonoma_005, sonoma_006, sonoma_007, sonoma_008, sonoma_009, sonoma_014, sonoma_016, sonoma_017, sonoma_022, sonoma_024, sonoma_032, sonoma_033, sonoma_036, sonoma_038, sonoma_045, sonoma_051, sonoma_053, sonoma_054, sonoma_055, sonoma_059, sonoma_061, sonoma_064, sonoma_081, sonoma_086, sonoma_087, sonoma_094, sonoma_095, sonoma_097, sonoma_106, sonoma_107 and sonoma_119. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06289 mRNA Translation: CAA29617.1
Y00222 mRNA Translation: CAA68369.1
AY437145
, AY437140, AY437141, AY437142, AY437143, AY437144 Genomic DNA Translation: AAR21453.1
AY437151
, AY437146, AY437147, AY437148, AY437149, AY437150 Genomic DNA Translation: AAR21454.1
AY437157
, AY437152, AY437153, AY437154, AY437155, AY437156 Genomic DNA Translation: AAR21455.1
AY437163
, AY437158, AY437159, AY437160, AY437161, AY437162 Genomic DNA Translation: AAR21456.1
AY437169
, AY437164, AY437165, AY437166, AY437167, AY437168 Genomic DNA Translation: AAR21457.1
AY437175
, AY437170, AY437171, AY437172, AY437173, AY437174 Genomic DNA Translation: AAR21458.1
AY437181
, AY437176, AY437177, AY437178, AY437179, AY437180 Genomic DNA Translation: AAR21459.1
AY437187
, AY437182, AY437183, AY437184, AY437185, AY437186 Genomic DNA Translation: AAR21460.1
AY437193
, AY437188, AY437189, AY437190, AY437191, AY437192 Genomic DNA Translation: AAR21461.1
AY437199
, AY437194, AY437195, AY437196, AY437197, AY437198 Genomic DNA Translation: AAR21462.1
AY437205
, AY437200, AY437201, AY437202, AY437203, AY437204 Genomic DNA Translation: AAR21463.1
AY437211
, AY437206, AY437207, AY437208, AY437209, AY437210 Genomic DNA Translation: AAR21464.1
AY437217
, AY437212, AY437213, AY437214, AY437215, AY437216 Genomic DNA Translation: AAR21465.1
AY437223
, AY437218, AY437219, AY437220, AY437221, AY437222 Genomic DNA Translation: AAR21466.1
AY437229
, AY437224, AY437225, AY437226, AY437227, AY437228 Genomic DNA Translation: AAR21467.1
AY437235
, AY437230, AY437231, AY437232, AY437233, AY437234 Genomic DNA Translation: AAR21468.1
AY438104 Genomic DNA Translation: AAR21469.1
AY438105 Genomic DNA Translation: AAR21470.1
AY438106 Genomic DNA Translation: AAR21471.1
AY438107 Genomic DNA Translation: AAR21472.1
AY438108 Genomic DNA Translation: AAR21473.1
AY438109 Genomic DNA Translation: AAR21474.1
AY438110 Genomic DNA Translation: AAR21475.1
AY438111 Genomic DNA Translation: AAR21476.1
AY438112 Genomic DNA Translation: AAR21477.1
AY438113 Genomic DNA Translation: AAR21478.1
AY438114 Genomic DNA Translation: AAR21479.1
AY438115 Genomic DNA Translation: AAR21480.1
AY438116 Genomic DNA Translation: AAR21481.1
AY438117 Genomic DNA Translation: AAR21482.1
AY438118 Genomic DNA Translation: AAR21483.1
AY438119 Genomic DNA Translation: AAR21484.1
AY438120 Genomic DNA Translation: AAR21485.1
AY438121 Genomic DNA Translation: AAR21486.1
AY438122 Genomic DNA Translation: AAR21487.1
AY438123 Genomic DNA Translation: AAR21488.1
AY438124 Genomic DNA Translation: AAR21489.1
AY438125 Genomic DNA Translation: AAR21490.1
AY438126 Genomic DNA Translation: AAR21491.1
AY438127 Genomic DNA Translation: AAR21492.1
AY438128 Genomic DNA Translation: AAR21493.1
AY438129 Genomic DNA Translation: AAR21494.1
AY438130 Genomic DNA Translation: AAR21495.1
AY438131 Genomic DNA Translation: AAR21496.1
AY438132 Genomic DNA Translation: AAR21497.1
AY438133 Genomic DNA Translation: AAR21498.1
AY438134 Genomic DNA Translation: AAR21499.1
AY438135 Genomic DNA Translation: AAR21500.1
AY438136 Genomic DNA Translation: AAR21501.1
AY438137 Genomic DNA Translation: AAR21502.1
AY438138 Genomic DNA Translation: AAR21503.1
AY438139 Genomic DNA Translation: AAR21504.1
AY438140 Genomic DNA Translation: AAR21505.1
AY438141 Genomic DNA Translation: AAR21506.1
AY438147 Genomic DNA Translation: AAR09172.1
AY438148 Genomic DNA Translation: AAR09173.1
AY438149 Genomic DNA Translation: AAR09174.1
AY438150 Genomic DNA Translation: AAR09175.1
AY438151 Genomic DNA Translation: AAR09176.1
AY438152 Genomic DNA Translation: AAR09177.1
AY438153 Genomic DNA Translation: AAR09178.1
AY438154 Genomic DNA Translation: AAR09179.1
AY438155 Genomic DNA Translation: AAR09180.1
AY438156 Genomic DNA Translation: AAR09181.1
AY438157 Genomic DNA Translation: AAR09182.1
AY438158 Genomic DNA Translation: AAR09183.1
AY438159 Genomic DNA Translation: AAR09184.1
AY438160 Genomic DNA Translation: AAR09185.1
AY438161 Genomic DNA Translation: AAR09186.1
AY438162 Genomic DNA Translation: AAR09187.1
AY438163 Genomic DNA Translation: AAR09188.1
AY438164 Genomic DNA Translation: AAR09189.1
AY438165 Genomic DNA Translation: AAR09190.1
AY438166 Genomic DNA Translation: AAR09191.1
AY438167 Genomic DNA Translation: AAR09192.1
AY438168 Genomic DNA Translation: AAR09193.1
AY438169 Genomic DNA Translation: AAR09194.1
AY438170 Genomic DNA Translation: AAR09195.1
AY438171 Genomic DNA Translation: AAR09196.1
AY438172 Genomic DNA Translation: AAR09197.1
AY438173 Genomic DNA Translation: AAR09198.1
AY438174 Genomic DNA Translation: AAR09199.1
AY438175 Genomic DNA Translation: AAR09200.1
AY438176 Genomic DNA Translation: AAR09201.1
AY438177 Genomic DNA Translation: AAR09202.1
AY438178 Genomic DNA Translation: AAR09203.1
AY438179 Genomic DNA Translation: AAR09204.1
AY438180 Genomic DNA Translation: AAR09205.1
AY438181 Genomic DNA Translation: AAR09206.1
AY438182 Genomic DNA Translation: AAR09207.1
AY438183 Genomic DNA Translation: AAR09208.1
AY438184 Genomic DNA Translation: AAR09209.1
AY438185 Genomic DNA Translation: AAR09210.1
AY438186 Genomic DNA Translation: AAR09211.1
AY438187 Genomic DNA Translation: AAR09212.1
AY438188 Genomic DNA Translation: AAR09213.1
AY438189 Genomic DNA Translation: AAR09214.1
AY438190 Genomic DNA Translation: AAR09215.1
AY438191 Genomic DNA Translation: AAR09216.1
AY438192 Genomic DNA Translation: AAR09217.1
AY438193 Genomic DNA Translation: AAR09218.1
AY438194 Genomic DNA Translation: AAR09219.1
AY438195 Genomic DNA Translation: AAR09220.1
AY438196 Genomic DNA Translation: AAR09221.1
AY438197 Genomic DNA Translation: AAR09222.1
AY438198 Genomic DNA Translation: AAR09223.1
AY438199 Genomic DNA Translation: AAR09224.1
AY438200 Genomic DNA Translation: AAR09225.1
AY438201 Genomic DNA Translation: AAR09226.1
AY438202 Genomic DNA Translation: AAR09227.1
BK004004 Genomic DNA Translation: DAA02303.1
AE014297 Genomic DNA Translation: AAF55657.1
BT003267 mRNA Translation: AAO25024.1
AY061269 mRNA Translation: AAL28817.1 Different initiation.
X05140 mRNA Translation: CAA28786.1
PIRiA31246
A43564
S00670
S19087
RefSeqiNP_001247193.1, NM_001260264.2
NP_477264.1, NM_057916.4
NP_732412.1, NM_169853.3
UniGeneiDm.7687

Genome annotation databases

EnsemblMetazoaiFBtr0083739; FBpp0083153; FBgn0000463
FBtr0083740; FBpp0083154; FBgn0000463
FBtr0304658; FBpp0293200; FBgn0000463
GeneIDi42313
KEGGidme:Dmel_CG3619

Similar proteinsi

Entry informationi

Entry nameiDL_DROME
AccessioniPrimary (citable) accession number: P10041
Secondary accession number(s): Q6T3F7
, Q6T3G1, Q6T3G7, Q6T3G8, Q6T3H0, Q6T3H3, Q6T3I3, Q6T3I5, Q6T3I7, Q6T3J1, Q6T3J2, Q6T3J3, Q6T3J4, Q6T3K0, Q6T3K1, Q6T3K9, Q6T3L5, Q6T3L7, Q6T3L9, Q6T3M2, Q6T3M4, Q6T3M7, Q6T3N1, Q6T3N3, Q6T3N5, Q6T3N7, Q6T4M9, Q6T4N0, Q6T4N1, Q6T4N2, Q6T4N3, Q6T4N4, Q6T4N6, Q95RM9, Q99108, Q9VDY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 199 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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