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Protein

Neurogenic locus protein delta

Gene

Dl

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a ligand for Notch (N) receptor. Essential for proper differentiation of ectoderm. Dl is required for the correct separation of neural and epidermal cell lineages. Fringe (fng) acts in the Golgi to determine the type of O-linked fucose on the EGF modules in N, altering the ability of N to bind with Delta (Dl). O-fut1 also has a role in modulating the interaction.1 Publication

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • Notch binding Source: FlyBase
  • receptor binding Source: FlyBase

GO - Biological processi

  • actin filament organization Source: FlyBase
  • antennal morphogenesis Source: FlyBase
  • apposition of dorsal and ventral imaginal disc-derived wing surfaces Source: FlyBase
  • asymmetric cell division Source: FlyBase
  • border follicle cell migration Source: FlyBase
  • cell adhesion Source: FlyBase
  • cell fate specification Source: FlyBase
  • central nervous system development Source: FlyBase
  • chaeta morphogenesis Source: FlyBase
  • compound eye cone cell fate commitment Source: FlyBase
  • compound eye development Source: FlyBase
  • compound eye retinal cell programmed cell death Source: FlyBase
  • dorsal/ventral lineage restriction, imaginal disc Source: FlyBase
  • ectoderm development Source: FlyBase
  • establishment of ommatidial planar polarity Source: FlyBase
  • establishment of planar polarity Source: FlyBase
  • germ-line stem cell population maintenance Source: FlyBase
  • glial cell migration Source: FlyBase
  • imaginal disc-derived leg morphogenesis Source: FlyBase
  • imaginal disc-derived leg segmentation Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • imaginal disc-derived wing vein morphogenesis Source: FlyBase
  • imaginal disc-derived wing vein specification Source: FlyBase
  • lateral inhibition Source: FlyBase
  • mesoderm development Source: FlyBase
  • negative regulation of fusion cell fate specification Source: FlyBase
  • negative regulation of neurogenesis Source: FlyBase
  • negative regulation of terminal cell fate specification, open tracheal system Source: FlyBase
  • nervous system development Source: FlyBase
  • Notch signaling pathway Source: FlyBase
  • ommatidial rotation Source: FlyBase
  • oocyte anterior/posterior axis specification Source: FlyBase
  • oocyte localization involved in germarium-derived egg chamber formation Source: FlyBase
  • oogenesis Source: FlyBase
  • open tracheal system development Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • ovarian follicle cell stalk formation Source: FlyBase
  • peripheral nervous system development Source: FlyBase
  • positive regulation of cell proliferation Source: FlyBase
  • positive regulation of mitotic cell cycle Source: FlyBase
  • R3/R4 cell fate commitment Source: FlyBase
  • R8 cell differentiation Source: FlyBase
  • R8 cell fate commitment Source: FlyBase
  • regulation of R8 cell spacing in compound eye Source: FlyBase
  • second mitotic wave involved in compound eye morphogenesis Source: FlyBase
  • sensory organ development Source: FlyBase
  • sensory perception of pain Source: FlyBase
  • stem cell differentiation Source: FlyBase
  • ventral cord development Source: FlyBase
  • wing disc dorsal/ventral pattern formation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Notch signaling pathway

Enzyme and pathway databases

ReactomeiR-DME-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
R-DME-2979096. NOTCH2 Activation and Transmission of Signal to the Nucleus.
SignaLinkiP10041.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenic locus protein delta
Gene namesi
Name:Dl
ORF Names:CG3619
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0000463. Dl.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 594576ExtracellularSequence analysisAdd
BLAST
Transmembranei595 – 61723HelicalSequence analysisAdd
BLAST
Topological domaini618 – 833216CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • adherens junction Source: FlyBase
  • cell surface Source: FlyBase
  • cytoplasmic vesicle Source: FlyBase
  • endocytic vesicle Source: FlyBase
  • endosome Source: FlyBase
  • integral component of membrane Source: FlyBase
  • plasma membrane Source: FlyBase
  • subapical complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 833815Neurogenic locus protein deltaPRO_0000007505Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 61By similarity
Disulfide bondi68 ↔ 82By similarity
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence analysis
Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence analysis
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence analysis
Disulfide bondi184 ↔ 193PROSITE-ProRule annotationBy similarity
Disulfide bondi197 ↔ 209PROSITE-ProRule annotationBy similarity
Disulfide bondi217 ↔ 226PROSITE-ProRule annotationBy similarity
Disulfide bondi231 ↔ 240PROSITE-ProRule annotationBy similarity
Disulfide bondi235 ↔ 246PROSITE-ProRule annotationBy similarity
Disulfide bondi248 ↔ 257PROSITE-ProRule annotationBy similarity
Disulfide bondi260 ↔ 271By similarity
Disulfide bondi266 ↔ 277By similarity
Disulfide bondi279 ↔ 288PROSITE-ProRule annotationBy similarity
Disulfide bondi295 ↔ 307By similarity
Disulfide bondi301 ↔ 317By similarity
Disulfide bondi319 ↔ 328By similarity
Disulfide bondi335 ↔ 348By similarity
Disulfide bondi342 ↔ 360By similarity
Disulfide bondi362 ↔ 371By similarity
Disulfide bondi378 ↔ 388By similarity
Disulfide bondi383 ↔ 404By similarity
Disulfide bondi406 ↔ 415By similarity
Disulfide bondi422 ↔ 433By similarity
Disulfide bondi427 ↔ 439By similarity
Disulfide bondi441 ↔ 450By similarity
Disulfide bondi457 ↔ 468By similarity
Disulfide bondi462 ↔ 477By similarity
Disulfide bondi479 ↔ 488By similarity
Disulfide bondi495 ↔ 506By similarity
Disulfide bondi500 ↔ 515By similarity
Disulfide bondi517 ↔ 526By similarity
Disulfide bondi533 ↔ 544By similarity
Disulfide bondi538 ↔ 553By similarity
Disulfide bondi555 ↔ 564By similarity
Modified residuei666 – 6661Phosphothreonine1 Publication

Post-translational modificationi

Ubiquitinated by Mib, leading to its endocytosis and subsequent degradation.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP10041.

PTM databases

iPTMnetiP10041.

Miscellaneous databases

PMAP-CutDBP10041.

Expressioni

Tissue specificityi

Detected in all areas with neurogenic abilities, for example the neurogenic ectoderm and the primordia of the sense organs. Later expression is restricted to those cells that have adopted a neural fate.1 Publication

Developmental stagei

Expressed both maternally and zygotically. Expression is highest early in embryonic development (stage 5) and reduces to a low level during larval stages.1 Publication

Gene expression databases

BgeeiP10041.
ExpressionAtlasiP10041. differential.
GenevisibleiP10041. DM.

Interactioni

Subunit structurei

Interacts with N via the EGF repeats and the N EGF repeats.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NP072072EBI-115346,EBI-103438

GO - Molecular functioni

  • Notch binding Source: FlyBase
  • receptor binding Source: FlyBase

Protein-protein interaction databases

BioGridi67310. 59 interactions.
DIPiDIP-22726N.
IntActiP10041. 2 interactions.
MINTiMINT-773349.
STRINGi7227.FBpp0083153.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4XIBX-ray2.15C680-690[»]
ProteinModelPortaliP10041.
SMRiP10041. Positions 23-573.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini182 – 22645DSLPROSITE-ProRule annotationAdd
BLAST
Domaini227 – 25832EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini256 – 28934EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini291 – 32939EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini331 – 37242EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini374 – 41643EGF-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini418 – 45134EGF-like 6PROSITE-ProRule annotationAdd
BLAST
Domaini453 – 48937EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini491 – 52737EGF-like 8PROSITE-ProRule annotationAdd
BLAST
Domaini529 – 56537EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DSL domain.PROSITE-ProRule annotation
Contains 9 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR7B. Eukaryota.
ENOG410XUNS. LUCA.
GeneTreeiENSGT00810000125346.
InParanoidiP10041.
KOiK06051.
OMAiECVCANG.
OrthoDBiEOG7GQXZ5.
PhylomeDBiP10041.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR011651. Notch_ligand_N.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 7 hits.
PF07657. MNNL. 1 hit.
[Graphical view]
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 9 hits.
SM00179. EGF_CA. 7 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 9 hits.
PS01186. EGF_2. 9 hits.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10041-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHWIKCLLTA FICFTVIVQV HSSGSFELRL KYFSNDHGRD NEGRCCSGES
60 70 80 90 100
DGATGKCLGS CKTRFRVCLK HYQATIDTTS QCTYGDVITP ILGENSVNLT
110 120 130 140 150
DAQRFQNKGF TNPIQFPFSF SWPGTFSLIV EAWHDTNNSG NARTNKLLIQ
160 170 180 190 200
RLLVQQVLEV SSEWKTNKSE SQYTSLEYDF RVTCDLNYYG SGCAKFCRPR
210 220 230 240 250
DDSFGHSTCS ETGEIICLTG WQGDYCHIPK CAKGCEHGHC DKPNQCVCQL
260 270 280 290 300
GWKGALCNEC VLEPNCIHGT CNKPWTCICN EGWGGLYCNQ DLNYCTNHRP
310 320 330 340 350
CKNGGTCFNT GEGLYTCKCA PGYSGDDCEN EIYSCDADVN PCQNGGTCID
360 370 380 390 400
EPHTKTGYKC HCANGWSGKM CEEKVLTCSD KPCHQGICRN VRPGLGSKGQ
410 420 430 440 450
GYQCECPIGY SGPNCDLQLD NCSPNPCING GSCQPSGKCI CPAGFSGTRC
460 470 480 490 500
ETNIDDCLGH QCENGGTCID MVNQYRCQCV PGFHGTHCSS KVDLCLIRPC
510 520 530 540 550
ANGGTCLNLN NDYQCTCRAG FTGKDCSVDI DECSSGPCHN GGTCMNRVNS
560 570 580 590 600
FECVCANGFR GKQCDEESYD SVTFDAHQYG ATTQARADGL TNAQVVLIAV
610 620 630 640 650
FSVAMPLVAV IAACVVFCMK RKRKRAQEKD DAEARKQNEQ NAVATMHHNG
660 670 680 690 700
SGVGVALASA SLGGKTGSNS GLTFDGGNPN IIKNTWDKSV NNICASAAAA
710 720 730 740 750
AAAAAAADEC LMYGGYVASV ADNNNANSDF CVAPLQRAKS QKQLNTDPTL
760 770 780 790 800
MHRGSPAGSS AKGASGGGPG AAEGKRISVL GEGSYCSQRW PSLAAAGVAG
810 820 830
ACSSQLMAAA SVAGSGAGTA QQQRSVVCGT PHM
Length:833
Mass (Da):88,841
Last modified:December 1, 2000 - v2
Checksum:iEDBA107A0003D9A1
GO

Sequence cautioni

The sequence AAL28817.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti437 – 4382GK → ET in CAA28786 (PubMed:3107986).Curated
Sequence conflicti443 – 4431A → S in CAA28786 (PubMed:3107986).Curated
Sequence conflicti459 – 4591G → A in CAA28786 (PubMed:3107986).Curated
Sequence conflicti490 – 4901S → T in CAA28786 (PubMed:3107986).Curated
Sequence conflicti591 – 5911T → A in CAA28786 (PubMed:3107986).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti398 – 3981K → R in strain: sonoma_017.
Natural varianti443 – 4431A → T in strain: sonoma_009, sonoma_051, sonoma_053 and sonoma_054.
Natural varianti461 – 4611Q → K in strain: sonoma_010, sonoma_013, sonoma_019 and sonoma_117.
Natural varianti652 – 6521G → A in strain: NapaValley5, NapaValley12, sonoma_015, sonoma_016, sonoma_023, sonoma_032, sonoma_034, sonoma_038, sonoma_040, sonoma_045, sonoma_048, sonoma_050, sonoma_061, sonoma_073, sonoma_081, sonoma_085, sonoma_094, sonoma_097 and sonoma_119. 1 Publication
Natural varianti662 – 6621L → M in strain: sonoma_008, sonoma_015, sonoma_016, sonoma_032, sonoma_034, sonoma_038, sonoma_040, sonoma_045, sonoma_048, sonoma_050, sonoma_061, sonoma_073, sonoma_081, sonoma_085, sonoma_094 and sonoma_097. 1 Publication
Natural varianti761 – 7611A → T in strain: sonoma_006, sonoma_022 and sonoma_040.
Natural varianti787 – 7871S → G in strain: nps_6, nps_18, nps_34, sonoma_048 and sonoma_050.
Natural varianti800 – 8001G → R in strain: sonoma_002.
Natural varianti812 – 8121V → A in strain: nps_19, nps_21, nps_25, nps_26, nps_27, nps_30, nps_31, nps_33, nps_35, nps_42, nps_43, nps_45, nps_47, sonoma_002, sonoma_003, sonoma_004, sonoma_005, sonoma_006, sonoma_007, sonoma_008, sonoma_009, sonoma_014, sonoma_016, sonoma_017, sonoma_022, sonoma_024, sonoma_032, sonoma_033, sonoma_036, sonoma_038, sonoma_045, sonoma_051, sonoma_053, sonoma_054, sonoma_055, sonoma_059, sonoma_061, sonoma_064, sonoma_081, sonoma_086, sonoma_087, sonoma_094, sonoma_095, sonoma_097, sonoma_106, sonoma_107 and sonoma_119. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06289 mRNA. Translation: CAA29617.1.
Y00222 mRNA. Translation: CAA68369.1.
AY437145
, AY437140, AY437141, AY437142, AY437143, AY437144 Genomic DNA. Translation: AAR21453.1.
AY437151
, AY437146, AY437147, AY437148, AY437149, AY437150 Genomic DNA. Translation: AAR21454.1.
AY437157
, AY437152, AY437153, AY437154, AY437155, AY437156 Genomic DNA. Translation: AAR21455.1.
AY437163
, AY437158, AY437159, AY437160, AY437161, AY437162 Genomic DNA. Translation: AAR21456.1.
AY437169
, AY437164, AY437165, AY437166, AY437167, AY437168 Genomic DNA. Translation: AAR21457.1.
AY437175
, AY437170, AY437171, AY437172, AY437173, AY437174 Genomic DNA. Translation: AAR21458.1.
AY437181
, AY437176, AY437177, AY437178, AY437179, AY437180 Genomic DNA. Translation: AAR21459.1.
AY437187
, AY437182, AY437183, AY437184, AY437185, AY437186 Genomic DNA. Translation: AAR21460.1.
AY437193
, AY437188, AY437189, AY437190, AY437191, AY437192 Genomic DNA. Translation: AAR21461.1.
AY437199
, AY437194, AY437195, AY437196, AY437197, AY437198 Genomic DNA. Translation: AAR21462.1.
AY437205
, AY437200, AY437201, AY437202, AY437203, AY437204 Genomic DNA. Translation: AAR21463.1.
AY437211
, AY437206, AY437207, AY437208, AY437209, AY437210 Genomic DNA. Translation: AAR21464.1.
AY437217
, AY437212, AY437213, AY437214, AY437215, AY437216 Genomic DNA. Translation: AAR21465.1.
AY437223
, AY437218, AY437219, AY437220, AY437221, AY437222 Genomic DNA. Translation: AAR21466.1.
AY437229
, AY437224, AY437225, AY437226, AY437227, AY437228 Genomic DNA. Translation: AAR21467.1.
AY437235
, AY437230, AY437231, AY437232, AY437233, AY437234 Genomic DNA. Translation: AAR21468.1.
AY438104 Genomic DNA. Translation: AAR21469.1.
AY438105 Genomic DNA. Translation: AAR21470.1.
AY438106 Genomic DNA. Translation: AAR21471.1.
AY438107 Genomic DNA. Translation: AAR21472.1.
AY438108 Genomic DNA. Translation: AAR21473.1.
AY438109 Genomic DNA. Translation: AAR21474.1.
AY438110 Genomic DNA. Translation: AAR21475.1.
AY438111 Genomic DNA. Translation: AAR21476.1.
AY438112 Genomic DNA. Translation: AAR21477.1.
AY438113 Genomic DNA. Translation: AAR21478.1.
AY438114 Genomic DNA. Translation: AAR21479.1.
AY438115 Genomic DNA. Translation: AAR21480.1.
AY438116 Genomic DNA. Translation: AAR21481.1.
AY438117 Genomic DNA. Translation: AAR21482.1.
AY438118 Genomic DNA. Translation: AAR21483.1.
AY438119 Genomic DNA. Translation: AAR21484.1.
AY438120 Genomic DNA. Translation: AAR21485.1.
AY438121 Genomic DNA. Translation: AAR21486.1.
AY438122 Genomic DNA. Translation: AAR21487.1.
AY438123 Genomic DNA. Translation: AAR21488.1.
AY438124 Genomic DNA. Translation: AAR21489.1.
AY438125 Genomic DNA. Translation: AAR21490.1.
AY438126 Genomic DNA. Translation: AAR21491.1.
AY438127 Genomic DNA. Translation: AAR21492.1.
AY438128 Genomic DNA. Translation: AAR21493.1.
AY438129 Genomic DNA. Translation: AAR21494.1.
AY438130 Genomic DNA. Translation: AAR21495.1.
AY438131 Genomic DNA. Translation: AAR21496.1.
AY438132 Genomic DNA. Translation: AAR21497.1.
AY438133 Genomic DNA. Translation: AAR21498.1.
AY438134 Genomic DNA. Translation: AAR21499.1.
AY438135 Genomic DNA. Translation: AAR21500.1.
AY438136 Genomic DNA. Translation: AAR21501.1.
AY438137 Genomic DNA. Translation: AAR21502.1.
AY438138 Genomic DNA. Translation: AAR21503.1.
AY438139 Genomic DNA. Translation: AAR21504.1.
AY438140 Genomic DNA. Translation: AAR21505.1.
AY438141 Genomic DNA. Translation: AAR21506.1.
AY438147 Genomic DNA. Translation: AAR09172.1.
AY438148 Genomic DNA. Translation: AAR09173.1.
AY438149 Genomic DNA. Translation: AAR09174.1.
AY438150 Genomic DNA. Translation: AAR09175.1.
AY438151 Genomic DNA. Translation: AAR09176.1.
AY438152 Genomic DNA. Translation: AAR09177.1.
AY438153 Genomic DNA. Translation: AAR09178.1.
AY438154 Genomic DNA. Translation: AAR09179.1.
AY438155 Genomic DNA. Translation: AAR09180.1.
AY438156 Genomic DNA. Translation: AAR09181.1.
AY438157 Genomic DNA. Translation: AAR09182.1.
AY438158 Genomic DNA. Translation: AAR09183.1.
AY438159 Genomic DNA. Translation: AAR09184.1.
AY438160 Genomic DNA. Translation: AAR09185.1.
AY438161 Genomic DNA. Translation: AAR09186.1.
AY438162 Genomic DNA. Translation: AAR09187.1.
AY438163 Genomic DNA. Translation: AAR09188.1.
AY438164 Genomic DNA. Translation: AAR09189.1.
AY438165 Genomic DNA. Translation: AAR09190.1.
AY438166 Genomic DNA. Translation: AAR09191.1.
AY438167 Genomic DNA. Translation: AAR09192.1.
AY438168 Genomic DNA. Translation: AAR09193.1.
AY438169 Genomic DNA. Translation: AAR09194.1.
AY438170 Genomic DNA. Translation: AAR09195.1.
AY438171 Genomic DNA. Translation: AAR09196.1.
AY438172 Genomic DNA. Translation: AAR09197.1.
AY438173 Genomic DNA. Translation: AAR09198.1.
AY438174 Genomic DNA. Translation: AAR09199.1.
AY438175 Genomic DNA. Translation: AAR09200.1.
AY438176 Genomic DNA. Translation: AAR09201.1.
AY438177 Genomic DNA. Translation: AAR09202.1.
AY438178 Genomic DNA. Translation: AAR09203.1.
AY438179 Genomic DNA. Translation: AAR09204.1.
AY438180 Genomic DNA. Translation: AAR09205.1.
AY438181 Genomic DNA. Translation: AAR09206.1.
AY438182 Genomic DNA. Translation: AAR09207.1.
AY438183 Genomic DNA. Translation: AAR09208.1.
AY438184 Genomic DNA. Translation: AAR09209.1.
AY438185 Genomic DNA. Translation: AAR09210.1.
AY438186 Genomic DNA. Translation: AAR09211.1.
AY438187 Genomic DNA. Translation: AAR09212.1.
AY438188 Genomic DNA. Translation: AAR09213.1.
AY438189 Genomic DNA. Translation: AAR09214.1.
AY438190 Genomic DNA. Translation: AAR09215.1.
AY438191 Genomic DNA. Translation: AAR09216.1.
AY438192 Genomic DNA. Translation: AAR09217.1.
AY438193 Genomic DNA. Translation: AAR09218.1.
AY438194 Genomic DNA. Translation: AAR09219.1.
AY438195 Genomic DNA. Translation: AAR09220.1.
AY438196 Genomic DNA. Translation: AAR09221.1.
AY438197 Genomic DNA. Translation: AAR09222.1.
AY438198 Genomic DNA. Translation: AAR09223.1.
AY438199 Genomic DNA. Translation: AAR09224.1.
AY438200 Genomic DNA. Translation: AAR09225.1.
AY438201 Genomic DNA. Translation: AAR09226.1.
AY438202 Genomic DNA. Translation: AAR09227.1.
BK004004 Genomic DNA. Translation: DAA02303.1.
AE014297 Genomic DNA. Translation: AAF55657.1.
BT003267 mRNA. Translation: AAO25024.1.
AY061269 mRNA. Translation: AAL28817.1. Different initiation.
X05140 mRNA. Translation: CAA28786.1.
PIRiA31246.
A43564.
S00670.
S19087.
RefSeqiNP_001247193.1. NM_001260264.2.
NP_477264.1. NM_057916.4.
NP_732412.1. NM_169853.3.
UniGeneiDm.7687.

Genome annotation databases

EnsemblMetazoaiFBtr0083739; FBpp0083153; FBgn0000463.
FBtr0083740; FBpp0083154; FBgn0000463.
FBtr0304658; FBpp0293200; FBgn0000463.
GeneIDi42313.
KEGGidme:Dmel_CG3619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06289 mRNA. Translation: CAA29617.1.
Y00222 mRNA. Translation: CAA68369.1.
AY437145
, AY437140, AY437141, AY437142, AY437143, AY437144 Genomic DNA. Translation: AAR21453.1.
AY437151
, AY437146, AY437147, AY437148, AY437149, AY437150 Genomic DNA. Translation: AAR21454.1.
AY437157
, AY437152, AY437153, AY437154, AY437155, AY437156 Genomic DNA. Translation: AAR21455.1.
AY437163
, AY437158, AY437159, AY437160, AY437161, AY437162 Genomic DNA. Translation: AAR21456.1.
AY437169
, AY437164, AY437165, AY437166, AY437167, AY437168 Genomic DNA. Translation: AAR21457.1.
AY437175
, AY437170, AY437171, AY437172, AY437173, AY437174 Genomic DNA. Translation: AAR21458.1.
AY437181
, AY437176, AY437177, AY437178, AY437179, AY437180 Genomic DNA. Translation: AAR21459.1.
AY437187
, AY437182, AY437183, AY437184, AY437185, AY437186 Genomic DNA. Translation: AAR21460.1.
AY437193
, AY437188, AY437189, AY437190, AY437191, AY437192 Genomic DNA. Translation: AAR21461.1.
AY437199
, AY437194, AY437195, AY437196, AY437197, AY437198 Genomic DNA. Translation: AAR21462.1.
AY437205
, AY437200, AY437201, AY437202, AY437203, AY437204 Genomic DNA. Translation: AAR21463.1.
AY437211
, AY437206, AY437207, AY437208, AY437209, AY437210 Genomic DNA. Translation: AAR21464.1.
AY437217
, AY437212, AY437213, AY437214, AY437215, AY437216 Genomic DNA. Translation: AAR21465.1.
AY437223
, AY437218, AY437219, AY437220, AY437221, AY437222 Genomic DNA. Translation: AAR21466.1.
AY437229
, AY437224, AY437225, AY437226, AY437227, AY437228 Genomic DNA. Translation: AAR21467.1.
AY437235
, AY437230, AY437231, AY437232, AY437233, AY437234 Genomic DNA. Translation: AAR21468.1.
AY438104 Genomic DNA. Translation: AAR21469.1.
AY438105 Genomic DNA. Translation: AAR21470.1.
AY438106 Genomic DNA. Translation: AAR21471.1.
AY438107 Genomic DNA. Translation: AAR21472.1.
AY438108 Genomic DNA. Translation: AAR21473.1.
AY438109 Genomic DNA. Translation: AAR21474.1.
AY438110 Genomic DNA. Translation: AAR21475.1.
AY438111 Genomic DNA. Translation: AAR21476.1.
AY438112 Genomic DNA. Translation: AAR21477.1.
AY438113 Genomic DNA. Translation: AAR21478.1.
AY438114 Genomic DNA. Translation: AAR21479.1.
AY438115 Genomic DNA. Translation: AAR21480.1.
AY438116 Genomic DNA. Translation: AAR21481.1.
AY438117 Genomic DNA. Translation: AAR21482.1.
AY438118 Genomic DNA. Translation: AAR21483.1.
AY438119 Genomic DNA. Translation: AAR21484.1.
AY438120 Genomic DNA. Translation: AAR21485.1.
AY438121 Genomic DNA. Translation: AAR21486.1.
AY438122 Genomic DNA. Translation: AAR21487.1.
AY438123 Genomic DNA. Translation: AAR21488.1.
AY438124 Genomic DNA. Translation: AAR21489.1.
AY438125 Genomic DNA. Translation: AAR21490.1.
AY438126 Genomic DNA. Translation: AAR21491.1.
AY438127 Genomic DNA. Translation: AAR21492.1.
AY438128 Genomic DNA. Translation: AAR21493.1.
AY438129 Genomic DNA. Translation: AAR21494.1.
AY438130 Genomic DNA. Translation: AAR21495.1.
AY438131 Genomic DNA. Translation: AAR21496.1.
AY438132 Genomic DNA. Translation: AAR21497.1.
AY438133 Genomic DNA. Translation: AAR21498.1.
AY438134 Genomic DNA. Translation: AAR21499.1.
AY438135 Genomic DNA. Translation: AAR21500.1.
AY438136 Genomic DNA. Translation: AAR21501.1.
AY438137 Genomic DNA. Translation: AAR21502.1.
AY438138 Genomic DNA. Translation: AAR21503.1.
AY438139 Genomic DNA. Translation: AAR21504.1.
AY438140 Genomic DNA. Translation: AAR21505.1.
AY438141 Genomic DNA. Translation: AAR21506.1.
AY438147 Genomic DNA. Translation: AAR09172.1.
AY438148 Genomic DNA. Translation: AAR09173.1.
AY438149 Genomic DNA. Translation: AAR09174.1.
AY438150 Genomic DNA. Translation: AAR09175.1.
AY438151 Genomic DNA. Translation: AAR09176.1.
AY438152 Genomic DNA. Translation: AAR09177.1.
AY438153 Genomic DNA. Translation: AAR09178.1.
AY438154 Genomic DNA. Translation: AAR09179.1.
AY438155 Genomic DNA. Translation: AAR09180.1.
AY438156 Genomic DNA. Translation: AAR09181.1.
AY438157 Genomic DNA. Translation: AAR09182.1.
AY438158 Genomic DNA. Translation: AAR09183.1.
AY438159 Genomic DNA. Translation: AAR09184.1.
AY438160 Genomic DNA. Translation: AAR09185.1.
AY438161 Genomic DNA. Translation: AAR09186.1.
AY438162 Genomic DNA. Translation: AAR09187.1.
AY438163 Genomic DNA. Translation: AAR09188.1.
AY438164 Genomic DNA. Translation: AAR09189.1.
AY438165 Genomic DNA. Translation: AAR09190.1.
AY438166 Genomic DNA. Translation: AAR09191.1.
AY438167 Genomic DNA. Translation: AAR09192.1.
AY438168 Genomic DNA. Translation: AAR09193.1.
AY438169 Genomic DNA. Translation: AAR09194.1.
AY438170 Genomic DNA. Translation: AAR09195.1.
AY438171 Genomic DNA. Translation: AAR09196.1.
AY438172 Genomic DNA. Translation: AAR09197.1.
AY438173 Genomic DNA. Translation: AAR09198.1.
AY438174 Genomic DNA. Translation: AAR09199.1.
AY438175 Genomic DNA. Translation: AAR09200.1.
AY438176 Genomic DNA. Translation: AAR09201.1.
AY438177 Genomic DNA. Translation: AAR09202.1.
AY438178 Genomic DNA. Translation: AAR09203.1.
AY438179 Genomic DNA. Translation: AAR09204.1.
AY438180 Genomic DNA. Translation: AAR09205.1.
AY438181 Genomic DNA. Translation: AAR09206.1.
AY438182 Genomic DNA. Translation: AAR09207.1.
AY438183 Genomic DNA. Translation: AAR09208.1.
AY438184 Genomic DNA. Translation: AAR09209.1.
AY438185 Genomic DNA. Translation: AAR09210.1.
AY438186 Genomic DNA. Translation: AAR09211.1.
AY438187 Genomic DNA. Translation: AAR09212.1.
AY438188 Genomic DNA. Translation: AAR09213.1.
AY438189 Genomic DNA. Translation: AAR09214.1.
AY438190 Genomic DNA. Translation: AAR09215.1.
AY438191 Genomic DNA. Translation: AAR09216.1.
AY438192 Genomic DNA. Translation: AAR09217.1.
AY438193 Genomic DNA. Translation: AAR09218.1.
AY438194 Genomic DNA. Translation: AAR09219.1.
AY438195 Genomic DNA. Translation: AAR09220.1.
AY438196 Genomic DNA. Translation: AAR09221.1.
AY438197 Genomic DNA. Translation: AAR09222.1.
AY438198 Genomic DNA. Translation: AAR09223.1.
AY438199 Genomic DNA. Translation: AAR09224.1.
AY438200 Genomic DNA. Translation: AAR09225.1.
AY438201 Genomic DNA. Translation: AAR09226.1.
AY438202 Genomic DNA. Translation: AAR09227.1.
BK004004 Genomic DNA. Translation: DAA02303.1.
AE014297 Genomic DNA. Translation: AAF55657.1.
BT003267 mRNA. Translation: AAO25024.1.
AY061269 mRNA. Translation: AAL28817.1. Different initiation.
X05140 mRNA. Translation: CAA28786.1.
PIRiA31246.
A43564.
S00670.
S19087.
RefSeqiNP_001247193.1. NM_001260264.2.
NP_477264.1. NM_057916.4.
NP_732412.1. NM_169853.3.
UniGeneiDm.7687.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4XIBX-ray2.15C680-690[»]
ProteinModelPortaliP10041.
SMRiP10041. Positions 23-573.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi67310. 59 interactions.
DIPiDIP-22726N.
IntActiP10041. 2 interactions.
MINTiMINT-773349.
STRINGi7227.FBpp0083153.

PTM databases

iPTMnetiP10041.

Proteomic databases

PaxDbiP10041.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0083739; FBpp0083153; FBgn0000463.
FBtr0083740; FBpp0083154; FBgn0000463.
FBtr0304658; FBpp0293200; FBgn0000463.
GeneIDi42313.
KEGGidme:Dmel_CG3619.

Organism-specific databases

FlyBaseiFBgn0000463. Dl.

Phylogenomic databases

eggNOGiENOG410IR7B. Eukaryota.
ENOG410XUNS. LUCA.
GeneTreeiENSGT00810000125346.
InParanoidiP10041.
KOiK06051.
OMAiECVCANG.
OrthoDBiEOG7GQXZ5.
PhylomeDBiP10041.

Enzyme and pathway databases

ReactomeiR-DME-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
R-DME-2979096. NOTCH2 Activation and Transmission of Signal to the Nucleus.
SignaLinkiP10041.

Miscellaneous databases

ChiTaRSiDl. fly.
GenomeRNAii42313.
PMAP-CutDBP10041.
PROiP10041.

Gene expression databases

BgeeiP10041.
ExpressionAtlasiP10041. differential.
GenevisibleiP10041. DM.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR011651. Notch_ligand_N.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 7 hits.
PF07657. MNNL. 1 hit.
[Graphical view]
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 9 hits.
SM00179. EGF_CA. 7 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 9 hits.
PS01186. EGF_2. 9 hits.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The neurogenic gene Delta of Drosophila melanogaster is expressed in neurogenic territories and encodes a putative transmembrane protein with EGF-like repeats."
    Vaessin H., Bremer K.A., Knust E., Campos-Ortega J.A.
    EMBO J. 6:3431-3440(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANTS ALA-652 AND MET-662.
    Tissue: Embryo.
  2. "Delta, a Drosophila neurogenic gene, is transcriptionally complex and encodes a protein related to blood coagulation factors and epidermal growth factor of vertebrates."
    Kopczynski C.C., Alton A.K., Fechtel K., Kooh P.J., Muskavitch M.A.T.
    Genes Dev. 2:1723-1735(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-812.
    Strain: Oregon-R.
    Tissue: Embryo.
  3. "No evidence for an association between common nonsynonymous polymorphisms in delta and bristle number variation in natural and laboratory populations of Drosophila melanogaster."
    Genissel A., Pastinen T., Dowell A., Mackay T.F.C., Long A.D.
    Genetics 166:291-306(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NapaValley1, NapaValley10, NapaValley11, NapaValley12, NapaValley2, NapaValley3, NapaValley4, NapaValley5, NapaValley6, NapaValley7, NapaValley8, NapaValley9, nps_1, nps_13, nps_14, nps_15, nps_16, nps_17, nps_18, nps_19, nps_2, nps_20, nps_21, nps_23, nps_24, nps_25, nps_26, nps_27, nps_28, nps_29, nps_3, nps_30, nps_31, nps_32, nps_33, nps_34, nps_35, nps_36, nps_37, nps_38, nps_39, nps_4, nps_40, nps_41, nps_42, nps_43, nps_44, nps_45, nps_46, nps_47, nps_48, nps_49, nps_5, nps_50, nps_6, sonoma_002, sonoma_003, sonoma_004, sonoma_005, sonoma_006, sonoma_007, sonoma_008, sonoma_009, sonoma_010, sonoma_013, sonoma_014, sonoma_015, sonoma_016, sonoma_017, sonoma_019, sonoma_022, sonoma_023, sonoma_024, sonoma_031, sonoma_032, sonoma_033, sonoma_034, sonoma_036, sonoma_038, sonoma_039, sonoma_040, sonoma_045, sonoma_046, sonoma_048, sonoma_050, sonoma_051, sonoma_053, sonoma_054, sonoma_055, sonoma_058, sonoma_059, sonoma_061, sonoma_064, sonoma_073, sonoma_074, sonoma_081, sonoma_085, sonoma_086, sonoma_087, sonoma_094, sonoma_095, sonoma_097, sonoma_101, sonoma_106, sonoma_107, sonoma_111, sonoma_116, sonoma_117 and sonoma_119.
  4. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  5. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  7. "A Drosophila full-length cDNA resource."
    Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
    Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 195-833.
    Strain: Berkeley.
    Tissue: Embryo.
  8. "EGF homologous sequences encoded in the genome of Drosophila melanogaster, and their relation to neurogenic genes."
    Knust E., Dietrich U., Tepass U., Bremer K.A., Weigel D., Vaessin H., Campos-Ortega J.A.
    EMBO J. 6:761-766(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 422-621.
    Tissue: Embryo.
  9. "Glycosyltransferase activity of Fringe modulates Notch-Delta interactions."
    Bruckner K., Perez L., Clausen H., Cohen S.
    Nature 406:411-415(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DL.
  10. "The pattern of transcription of the neurogenic gene Delta of Drosophila melanogaster."
    Haenlin M., Kramatschek B., Campos-Ortega J.A.
    Development 110:905-914(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PATTERN OF TRANSCRIPTION, CHARACTERIZATION.
  11. "The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta."
    Lai E.C., Roegiers F., Qin X., Jan Y.N., Rubin G.M.
    Development 132:2319-2332(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MIB, UBIQUITINATION.
  12. "Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila."
    Le Borgne R., Remaud S., Hamel S., Schweisguth F.
    PLoS Biol. 3:688-696(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION.
  13. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-666, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiDL_DROME
AccessioniPrimary (citable) accession number: P10041
Secondary accession number(s): Q6T3F7
, Q6T3G1, Q6T3G7, Q6T3G8, Q6T3H0, Q6T3H3, Q6T3I3, Q6T3I5, Q6T3I7, Q6T3J1, Q6T3J2, Q6T3J3, Q6T3J4, Q6T3K0, Q6T3K1, Q6T3K9, Q6T3L5, Q6T3L7, Q6T3L9, Q6T3M2, Q6T3M4, Q6T3M7, Q6T3N1, Q6T3N3, Q6T3N5, Q6T3N7, Q6T4M9, Q6T4N0, Q6T4N1, Q6T4N2, Q6T4N3, Q6T4N4, Q6T4N6, Q95RM9, Q99108, Q9VDY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 1, 2000
Last modified: June 8, 2016
This is version 181 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Miscellaneous

Separation of neuroblasts from the ectoderm into the inner part of embryo is one of the first steps of CNS development in insects, this process is under control of the neurogenic genes.
Notch and Serrate may interact at the protein level, it is conceivable that the Serrate and Delta proteins may compete for binding with the Notch protein.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.