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Protein

Homeobox protein mab-5

Gene

mab-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

During postembryonic development in C.elegans, posterior-specific pattern formation requires mab-5 (PubMed:2903796). Within the posterior body region, mab-5 activity controls epidermal, neuronal, and mesodermal cell differentiation (PubMed:2903796). Required for QL neuroblast daughter cell migration (PubMed:8898225).2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi115 – 17561HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: WormBase
  • localization Source: WormBase
  • negative regulation of transcription from RNA polymerase II promoter Source: WormBase
  • nematode male tail tip morphogenesis Source: WormBase
  • neuroblast migration Source: UniProtKB
  • positive regulation of epithelial cell proliferation Source: WormBase
  • positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  • regulation of cell fate specification Source: WormBase
  • regulation of cell migration Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiP10038.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein mab-5
Alternative name(s):
Protein male abnormal 5
Gene namesi
Name:mab-5
ORF Names:C08C3.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC08C3.3; CE25765; WBGene00003102; mab-5.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: WormBase
  • RNA polymerase II transcription factor complex Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Defective QL neuroblast daughter cell migration.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Homeobox protein mab-5PRO_0000049171Add
BLAST

Proteomic databases

PaxDbiP10038.

Expressioni

Tissue specificityi

Expressed asymmetrically in the QL neuroblast.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi41299. 3 interactions.
IntActiP10038. 7 interactions.
MINTiMINT-1123728.
STRINGi6239.C08C3.3.

Structurei

3D structure databases

ProteinModelPortaliP10038.
SMRiP10038. Positions 121-175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi103 – 1086Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi19 – 4426Ala/Ser/Thr-richAdd
BLAST
Compositional biasi38 – 447Poly-Ala

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000231181.
InParanoidiP10038.
KOiK09311.
OMAiTSANFGE.
OrthoDBiEOG780RP4.
PhylomeDBiP10038.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10038-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMYPGWTGD DSYWAGAGTT ASSQSASSGT SASASSSAAA AAAANNLKTY
60 70 80 90 100
ELYNHTYMNN MKHMLAAGWM DNSSNPFAYN PLQATSANFG ETRTSMPAIS
110 120 130 140 150
QPVFPWMKMG GAKGGESKRT RQTYSRSQTL ELEKEFHYHK YLTRKRRQEI
160 170 180 190 200
SETLHLTERQ VKIWFQNRRM KHKKEAKGEG GSNESDEESN QDEQNEQHSS
Length:200
Mass (Da):22,399
Last modified:May 27, 2002 - v3
Checksum:iEAC2DCA86F54E7E3
GO

Sequence cautioni

The sequence AAA28106.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22751 mRNA. Translation: AAA28106.1. Different initiation.
AF277990 mRNA. Translation: AAG00458.1.
FO080429 Genomic DNA. Translation: CCD63641.1.
PIRiS44615.
RefSeqiNP_498695.1. NM_066294.5.
UniGeneiCel.18387.

Genome annotation databases

EnsemblMetazoaiC08C3.3; C08C3.3; WBGene00003102.
GeneIDi176091.
KEGGicel:CELE_C08C3.3.
UCSCiC08C3.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22751 mRNA. Translation: AAA28106.1. Different initiation.
AF277990 mRNA. Translation: AAG00458.1.
FO080429 Genomic DNA. Translation: CCD63641.1.
PIRiS44615.
RefSeqiNP_498695.1. NM_066294.5.
UniGeneiCel.18387.

3D structure databases

ProteinModelPortaliP10038.
SMRiP10038. Positions 121-175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41299. 3 interactions.
IntActiP10038. 7 interactions.
MINTiMINT-1123728.
STRINGi6239.C08C3.3.

Proteomic databases

PaxDbiP10038.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC08C3.3; C08C3.3; WBGene00003102.
GeneIDi176091.
KEGGicel:CELE_C08C3.3.
UCSCiC08C3.3. c. elegans.

Organism-specific databases

CTDi176091.
WormBaseiC08C3.3; CE25765; WBGene00003102; mab-5.

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000231181.
InParanoidiP10038.
KOiK09311.
OMAiTSANFGE.
OrthoDBiEOG780RP4.
PhylomeDBiP10038.

Enzyme and pathway databases

SignaLinkiP10038.

Miscellaneous databases

PROiP10038.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Posterior pattern formation in C. elegans involves position-specific expression of a gene containing a homeobox."
    Costa M., Wir M., Coulson A., Sulston J., Kenyon C.
    Cell 55:747-756(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. "Determination of 5'-end of Caenorhabditis elegans mab-5 cDNA demonstrates a shorter N-terminal region than previously predicted."
    Grandien K., Sommer R.J.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  4. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  5. "Neuronal cell migration in C. elegans: regulation of Hox gene expression and cell position."
    Harris J., Honigberg L., Robinson N., Kenyon C.
    Development 122:3117-3131(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  6. "The Caenorhabditis elegans Ror RTK CAM-1 inhibits EGL-20/Wnt signaling in cell migration."
    Forrester W.C., Kim C., Garriga G.
    Genetics 168:1951-1962(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiMAB5_CAEEL
AccessioniPrimary (citable) accession number: P10038
Secondary accession number(s): Q9GZ02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: May 27, 2002
Last modified: June 8, 2016
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.