P10038 (MAB5_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein mab-5

Alternative name(s):
Protein male abnormal 5

Gene names

Name:	mab-5
ORF Names:	C08C3.3

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	During postembryonic development in C.elegans, posterior-specific pattern formation requires mab-5. Within the posterior body region, mab-5 activity controls epidermal, neuronal, and mesodermal cell differentiation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.
Sequence caution	The sequence AAA28106.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from mutant phenotype PubMed 9486792. Source: WormBase localization Inferred from mutant phenotype PubMed 8187641. Source: WormBase negative regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 12679110. Source: WormBase positive regulation of epithelial cell proliferation Inferred from mutant phenotype PubMed 8625851. Source: WormBase regulation of cell fate specification Inferred from mutant phenotype PubMed 9486792. Source: WormBase regulation of cell migration Inferred from mutant phenotype PubMed 8898225. Source: WormBase tail tip morphogenesis Inferred from mutant phenotype PubMed 11076762PubMed 8625851. Source: WormBase
Cellular_component	nucleus Inferred from direct assay PubMed 8625851. Source: WormBase
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 200	200	Homeobox protein mab-5		PRO_0000049171
Regions
	DNA binding	115 – 175	61	Homeobox
	Motif	103 – 108	6	Antp-type hexapeptide
	Compositional bias	19 – 44	26	Ala/Ser/Thr-rich
	Compositional bias	38 – 44	7	Poly-Ala

Sequences

	Sequence		Length	Mass (Da)
	P10038 [UniParc]. Last modified May 27, 2002. Version 3. Checksum: EAC2DCA86F54E7E3	FASTA	200	22,399
	10 20 30 40 50 60 MSMYPGWTGD DSYWAGAGTT ASSQSASSGT SASASSSAAA AAAANNLKTY ELYNHTYMNN 70 80 90 100 110 120 MKHMLAAGWM DNSSNPFAYN PLQATSANFG ETRTSMPAIS QPVFPWMKMG GAKGGESKRT 130 140 150 160 170 180 RQTYSRSQTL ELEKEFHYHK YLTRKRRQEI SETLHLTERQ VKIWFQNRRM KHKKEAKGEG 190 200 GSNESDEESN QDEQNEQHSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Posterior pattern formation in C. elegans involves position-specific expression of a gene containing a homeobox." Costa M., Wir M., Coulson A., Sulston J., Kenyon C. Cell 55:747-756(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Determination of 5'-end of Caenorhabditis elegans mab-5 cDNA demonstrates a shorter N-terminal region than previously predicted." Grandien K., Sommer R.J. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans." Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L. , Gardner A., Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., Wohldman P. Nature 368:32-38(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[4]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M22751 mRNA. Translation: AAA28106.1. Different initiation. AF277990 mRNA. Translation: AAG00458.1. FO080429 Genomic DNA. Translation: CCD63641.1.
PIR	S44615.
RefSeq	NP_498695.1. NM_066294.5.
UniGene	Cel.18387.
3D structure databases
ProteinModelPortal	P10038.
SMR	P10038. Positions 121-175.
ModBase	Search...
Protein-protein interaction databases
IntAct	P10038. 2 interactions.
MINT	MINT-1123728.
STRING	6239.C08C3.3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C08C3.3; C08C3.3; C08C3.3.
GeneID	176091.
KEGG	cel:CELE_C08C3.3.
UCSC	C08C3.3. c. elegans.
Organism-specific databases
CTD	176091.
WormBase	C08C3.3; CE25765; WBGene00003102; mab-5.
Phylogenomic databases
eggNOG	NOG238660.
GeneTree	ENSGT00700000104189.
HOGENOM	HOG000231181.
InParanoid	P10038.
KO	K09311.
OMA	TSANFGE.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	891072.

Entry information

Entry name

MAB5_CAEEL

Accession

Primary (citable) accession number: P10038
Secondary accession number(s): Q9GZ02

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	May 27, 2002
Last modified:	April 3, 2013
This is version 119 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project