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P10036

- PIT1_BOVIN

UniProt

P10036 - PIT1_BOVIN

Protein

Pituitary-specific positive transcription factor 1

Gene

POU1F1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi214 – 27360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pituitary-specific positive transcription factor 1
    Short name:
    PIT-1
    Alternative name(s):
    Growth hormone factor 1
    Short name:
    GHF-1
    Gene namesi
    Name:POU1F1
    Synonyms:GHF-1, PIT-1, PIT1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 291291Pituitary-specific positive transcription factor 1PRO_0000100695Add
    BLAST

    Proteomic databases

    PRIDEiP10036.

    Structurei

    3D structure databases

    ProteinModelPortaliP10036.
    SMRiP10036. Positions 129-273.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini124 – 19875POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG241031.
    HOGENOMiHOG000116302.
    HOVERGENiHBG053120.
    KOiK09363.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR015586. Pit_1.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view]
    PANTHERiPTHR11636:SF82. PTHR11636:SF82. 1 hit.
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10036-1 [UniParc]FASTAAdd to Basket

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    MSCQPFTSTD TFIPLNSESS ATLPLIMHPS AAECLPVSNH ATNVMSTATG    50
    LHYSVPFCHY GNQSSTYGVM AGSLTPCLYK FPDHTLSHGF PPMHQPLLSE 100
    DPTAADFKQE LRRKSKLVEE PIDMDSPEIR ELEKFANEFK VRRIKLGYTQ 150
    TNVGEALAAV HGSEFSQTTI CRFENLQLSF KNACKLKAIL SKWLEEAEQV 200
    GALYNEKVGA NERKRKRRTT ISIAAKDALE RHFGEQNKPS SQEILRMAEE 250
    LNLEKEVVRV WFCNRRQREK RVKTSLNQSL FTISKEHLEC R 291
    Length:291
    Mass (Da):33,039
    Last modified:July 1, 1989 - v1
    Checksum:i5439B7323113E8BE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12657 mRNA. Translation: CAA31184.1.
    PIRiA31305.
    RefSeqiNP_777004.1. NM_174579.3.
    UniGeneiBt.180.

    Genome annotation databases

    GeneIDi282315.
    KEGGibta:282315.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12657 mRNA. Translation: CAA31184.1 .
    PIRi A31305.
    RefSeqi NP_777004.1. NM_174579.3.
    UniGenei Bt.180.

    3D structure databases

    ProteinModelPortali P10036.
    SMRi P10036. Positions 129-273.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P10036.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 282315.
    KEGGi bta:282315.

    Organism-specific databases

    CTDi 5449.

    Phylogenomic databases

    eggNOGi NOG241031.
    HOGENOMi HOG000116302.
    HOVERGENi HBG053120.
    KOi K09363.

    Miscellaneous databases

    NextBioi 20806113.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR015586. Pit_1.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view ]
    PANTHERi PTHR11636:SF82. PTHR11636:SF82. 1 hit.
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein."
      Bodner M., Castrillo J.-L., Theill L.E., Deerinck T., Ellisman M., Karin M.
      Cell 55:505-518(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPIT1_BOVIN
    AccessioniPrimary (citable) accession number: P10036
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3