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Protein

Male determiner protein Mdmd(Y)

Gene

Mdmd

Organism
Musca domestica (House fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Male determiner protein (M-factor) that controls male somatic sexual differentiation. Acts as a dominant factor that regulates the mRNA splicing of transformer (tra) and doublesex (dsx) transcripts and promotes expression of male splice forms of tra and dsx (By similarity). Probably acts as a component of the spliceosome C complex required for mRNA splicing factor and exon-junction complex (EJC) assembly (By similarity). Hinders eIF4AIII from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs (By similarity).By similarity

Miscellaneous

M.domestica genome only codes for one male determiner Mdmd protein, which is encoded on the M region, and can be located at different loci on the genome (it can on the chromosome II, III, V or Y). The M region contains a cluster of tandemly repeated Mdmd copies with only one intact copy: other copies are degenerated with large truncations and frameshifts and assumed non-functional. The presence of multiple copies on the M region may preserve its integrity in a hostile non-recombining environment. This protein is encoded on chromosome Y.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDifferentiation, mRNA processing, mRNA splicing, Sexual differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Male determiner protein Mdmd(Y)1 Publication
Alternative name(s):
Male determiner encoded on chromosome YCurated
Gene namesi
Name:Mdmd1 Publication
OrganismiMusca domestica (House fly)
Taxonomic identifieri7370 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca
Proteomesi
  • UP000095301 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004413241 – 1174Male determiner protein Mdmd(Y)Add BLAST1174

Expressioni

Developmental stagei

Specifically expressed in early male embryos. Zygotic expression first appears in 2- to 3-hour-old embryos (cellularized blastoderm stage). Expression is then maintained throughout male development until adulthood.1 Publication

Interactioni

Subunit structurei

Component of the spliceosome C complex.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini348 – 531MIF4GPROSITE-ProRule annotationAdd BLAST184
Domaini641 – 757MIPROSITE-ProRule annotationAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi142 – 265Arg-richPROSITE-ProRule annotationAdd BLAST124
Compositional biasi840 – 960Ser-richPROSITE-ProRule annotationAdd BLAST121

Sequence similaritiesi

Belongs to the CWC22 family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR003890. MIF4G-like_typ-3.
PfamiView protein in Pfam
PF02847. MA3. 1 hit.
SMARTiView protein in SMART
SM00544. MA3. 1 hit.
SM00543. MIF4G. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiView protein in PROSITE
PS51366. MI. 1 hit.

Sequencei

Sequence statusi: Complete.

P0DP79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNATDAESRK PENKPSSESS SSGSTSGSSD GEVSSKTYFK NNKSKVLSGQ
60 70 80 90 100
REVVLEVVRD LSYTICKEAE EKLVERFPRK DGSNEMLPKE DSINTNHNYT
110 120 130 140 150
TDSDEHPVEL TTKTEECKNT EKTKKKSFVR ALSKDKQLSA YRSRSRSTRL
160 170 180 190 200
SYSGHISRTH SVEKSLSRYK KSVLRNRRTS FGHGRDSSTT KRSVSRDKDN
210 220 230 240 250
RLRRRIGSSR SHTRSHSRFR RSEKKLPSRS PRRIRSQERR HERRRSMSSD
260 270 280 290 300
YERIALRRSE PIKRRDKDEF FKNNKKVSGD IKKGKGNDNG TVAELEAKIT
310 320 330 340 350
ERQRKSLDIL TSRTGGACLT PDKLRMIQAE ITDKSSAAYQ SIAREALKKY
360 370 380 390 400
IHGYINKVNV DSVAVITRKL LKDNIVRGRG VLCHSIIQAQ ATSPKFTHVY
410 420 430 440 450
AAMVAIINSK FPNIGELLLK RLVIQFKRAF GCNDKTVCLT SSHFIAHLVN
460 470 480 490 500
QRVAHEILAL EILTLLIESP TDDNVEVAIT FLKECGMKLT EVSSDRVGGI
510 520 530 540 550
FELLKNILHQ GKLDKRVQYM IKVLFQVRRD GFKDHQSIIE SLELVEEYAQ
560 570 580 590 600
FTHLLLLEDV TYPKDILNEF KFDDQYETNE EKYKALSKNI LGSHASDSDG
610 620 630 640 650
SFGSGSNSET ALSDCDKGKN EVNDKYTSGD IIDETKPNLI ALRRTIYLTL
660 670 680 690 700
NSCLDYEECA QKLMKMQLKT CQQNEFCQIL LDCCAEQRTY EKFYGLLTHR
710 720 730 740 750
ICKMNKSFIE PFKEIFKDIC QTTHCLDTNR LRNISKFFAH LLFTDAISWD
760 770 780 790 800
VLDCIKLTED EAITSRCIFI KSFFQELVEY MGLYHFNKKL KTEVLAGTLA
810 820 830 840 850
GLFPKDNPRN IRFSINFFTS IGLGGITNEL CQLLKIAPKS APSSSSSSSL
860 870 880 890 900
SSELSAPSDD DSSSDSENKK KHKGKNKKMT KKKNPSKKKE ETKKIVGKNK
910 920 930 940 950
IAAKNKTIKR RTDKDNSSSK DNFLKSESSS NESISLDSLS SELFAPSSYS
960 970 980 990 1000
SSESSNDSES KEKHKGKNKK MTKKKNPSNK REKTKKKLSK NKKAPNKNTK
1010 1020 1030 1040 1050
KRMTEKDISS SESSISESKS LNCSASNQNE NEKRKKRVTS KSRTKRVKMF
1060 1070 1080 1090 1100
KQCQWVDADN QRDIKRKKRA EYRYEPLVYR KRNEEYLKKG GPNCRKDNYG
1110 1120 1130 1140 1150
NRQNHEISQR HDSEIKRRRE ERKKRHHEKN HSREYKRSKL GPCQREYFLY
1160 1170
MCCQFYYPCT FQCLCQNCHF TFYS
Length:1,174
Mass (Da):135,079
Last modified:August 30, 2017 - v1
Checksum:i9E2D1950E50F207A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KY020047 Genomic DNA. Translation: ART29445.1.

Similar proteinsi

Entry informationi

Entry nameiMDMY_MUSDO
AccessioniPrimary (citable) accession number: P0DP79
Secondary accession number(s): A0A1Y0AWT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2017
Last sequence update: August 30, 2017
Last modified: October 25, 2017
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families