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Protein

Omega-amidase YafV

Gene

yafV

Organism
Staphylococcus aureus (strain 04-02981)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes alpha-ketoglutaramate (a-KGM) to alpha-ketoglutarate (alpha-KG) and ammonia (specific activity 3.87 µmol/min/mg), has weak activity on L-glutamine, almost no activity on deaminated glutathione (dGSH) and none on glutathione. May function as a metabolite repair enzyme.1 Publication

Catalytic activityi

A monoamide of a dicarboxylate + H2O = a dicarboxylate + NH3.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei41Proton acceptorPROSITE-ProRule annotation1
Active sitei110PROSITE-ProRule annotation1
Active sitei146NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-amidase YafV (EC:3.5.1.31 Publication)
Short name:
saYafV1 Publication
Gene namesi
Name:yafV1 Publication
Synonyms:amiE1 Publication
Ordered Locus Names:SA2981_1975
OrganismiStaphylococcus aureus (strain 04-02981)
Taxonomic identifieri703339 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004406951 – 261Omega-amidase YafVAdd BLAST261

Structurei

3D structure databases

SMRiP0DP65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 239CN hydrolasePROSITE-ProRule annotationAdd BLAST239

Sequence similaritiesi

Phylogenomic databases

KOiK13566.
OMAiPEMFSTG.

Family and domain databases

Gene3Di3.60.110.10. 1 hit.
InterProiView protein in InterPro
IPR003010. C-N_Hydrolase.
IPR036526. C-N_Hydrolase_sf.
IPR001110. UPF0012_CS.
PfamiView protein in Pfam
PF00795. CN_hydrolase. 1 hit.
SUPFAMiSSF56317. SSF56317. 1 hit.
PROSITEiView protein in PROSITE
PS50263. CN_HYDROLASE. 1 hit.
PS01227. UPF0012. 1 hit.

Sequencei

Sequence statusi: Complete.

P0DP65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVQIYQLPI IFGDSSKNET QITQWFEKNM NAEVDVVVLP EMWNNGYDLE
60 70 80 90 100
HLNEKADNNL GQSFSFIKHL AEKYKVDIVA GSVSNIRNYQ IFNTAFSVNK
110 120 130 140 150
SGQLINEYDK VHLVPMLREH EFLTAGENVA EPFQLSDGTY VTQLICYDLR
160 170 180 190 200
FPELLRYPAR SGAKIAFYVA QWPMSRLQHW HSLLKARAIE NNMFVIGTNS
210 220 230 240 250
TGFDGNTEYA GHSIVINPNG DLVGELNESA DILTVDLNLN EVEQQRENIP
260
VFKSIKLDLY K
Length:261
Mass (Da):29,840
Last modified:July 5, 2017 - v1
Checksum:i99C197D6BB4811EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001844 Genomic DNA. Translation: ADC38186.1.
RefSeqiWP_000867951.1. NC_017340.1.

Genome annotation databases

KEGGisuy:SA2981_1975.

Similar proteinsi

Entry informationi

Entry nameiYAFV_STAA4
AccessioniPrimary (citable) accession number: P0DP65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2017
Last sequence update: July 5, 2017
Last modified: March 28, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program