Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ly-6/neurotoxin-like protein 1

Gene

LYNX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs) (PubMed:21252236). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane. Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs. Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-42:beta-23 to low sensitivity alpha-43:beta-22 nAChR (By similarity). In vitro modulates alpha-3:beta-4-containing nAChRs. Reduces cell surface expression of (alpha-3:beta-4)2:beta-4 and (alpha-3:beta-4)2:alpha-5 nAChRs suggesting an interaction with nAChR alpha-3-:+beta-4 subunit interfaces and an allosteric mode. Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)2:alpha-3 when compared to (alpha-3:beta-2)2:alpha-5 nAChRs (PubMed:28100642). Prevents plasticity in the primary visual cortex late in life (By similarity).By similarity2 Publications

Miscellaneous

Isoform 1 is considered to be an endogenous "prototoxin", that shares a N-terminal three-finger structure with snake alpha-neurotoxins.1 Publication

GO - Molecular functioni

  • acetylcholine receptor binding Source: UniProtKB
  • acetylcholine receptor inhibitor activity Source: Ensembl
  • acetylcholine receptor regulator activity Source: UniProtKB
  • ion channel inhibitor activity Source: Ensembl

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ly-6/neurotoxin-like protein 1Curated
Alternative name(s):
Endogenous prototoxin LYNX11 Publication
Testicular tissue protein Li 112Imported
Gene namesi
Name:LYNX1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:29604. LYNX1.
MIMi606110. gene.
neXtProtiNX_P0DP58.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180155.
PharmGKBiPA134874147.

Polymorphism and mutation databases

BioMutaiLYNX1.
DMDMi408360254.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003615421 – 91Ly-6/neurotoxin-like protein 1Sequence analysisAdd BLAST71
PropeptideiPRO_000044064192 – 116Removed in mature formSequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 46Combined sources1 Publication
Disulfide bondi26 ↔ 33Combined sources1 Publication
Disulfide bondi39 ↔ 64Combined sources1 Publication
Disulfide bondi68 ↔ 85Combined sources1 Publication
Disulfide bondi86 ↔ 91Combined sources1 Publication
Lipidationi91GPI-anchor amidated cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PeptideAtlasiP0DP58.
PRIDEiQ9BZG9.

Expressioni

Gene expression databases

CleanExiHS_LYNX1.
GenevisibleiQ9BZG9. HS.

Organism-specific databases

HPAiHPA023711.

Interactioni

Subunit structurei

Interacts with nAChRs containing alpha-4:beta-2 (CHRNA4:CHRNB2) and alpha-7 (CHRNA7) subunits. Interacts with CHRNA4 probably in the endoplasmic reticulum prior to nAChR pentameric assembly (By similarity).By similarity

GO - Molecular functioni

  • acetylcholine receptor binding Source: UniProtKB

Structurei

Secondary structure

1116
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 24Combined sources3
Beta strandi26 – 31Combined sources6
Beta strandi36 – 38Combined sources3
Beta strandi45 – 54Combined sources10
Beta strandi57 – 66Combined sources10
Beta strandi75 – 77Combined sources3
Beta strandi80 – 86Combined sources7
Turni89 – 92Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VYEmodel-A1-80[»]
2L03NMR-A21-93[»]
ProteinModelPortaliQ9BZG9.
SMRiP0DP58.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BZG9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 107UPAR/Ly6Sequence analysisAdd BLAST87

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JF98. Eukaryota.
ENOG41119HY. LUCA.
GeneTreeiENSGT00720000108940.
ENSGT00730000111571.
HOGENOMiHOG000035114.
HOVERGENiHBG052377.
InParanoidiQ9BZG9.
OMAiRTYYTPY.
PhylomeDBiQ9BZG9.

Family and domain databases

InterProiView protein in InterPro
IPR016054. LY6_UPA_recep-like.
IPR035076. Toxin/TOLIP.
PfamiView protein in Pfam
PF00087. Toxin_TOLIP. 1 hit.
SMARTiView protein in SMART
SM00134. LU. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P0DP58-1) [UniParc]FASTAAdd to basket
Also known as: LYNX11 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPLLTLILV VLMGLPLAQA LDCHVCAYNG DNCFNPMRCP AMVAYCMTTR
60 70 80 90 100
TYYTPTRMKV SKSCVPRCFE TVYDGYSKHA STTSCCQYDL CNGTGLATPA
110
TLALAPILLA TLWGLL
Length:116
Mass (Da):12,641
Last modified:July 5, 2017 - v1
Checksum:iBF5827EB64BFE6F6
GO
Isoform 2 (identifier: P0DP58-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: LYNX1-SLURP21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     52-116: YYTPTRMKVS...ILLATLWGLL → SAAEAIWCHQ...CCQTSLCNHD

Note: Based on a naturally occurring readthrough transcript which produces a LYNX1-SLURP2 fusion protein.1 Publication
Show »
Length:131
Mass (Da):14,026
Checksum:iFAD1259D48A036D7
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05897852 – 116YYTPT…LWGLL → SAAEAIWCHQCTGFGGCSHG SRCLRDSTHCVTTATRVLSN TEDLPLVTKMCHIGCPDIPS LGLGPYVSIACCQTSLCNHD in isoform 2. Add BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM005425 mRNA. Translation: AEE61023.1.
AC083841 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82299.1.
CH471162 Genomic DNA. Translation: EAW82301.1.
CH471162 Genomic DNA. Translation: EAW82302.1.
CH471162 Genomic DNA. Translation: EAW82303.1.
CH471162 Genomic DNA. Translation: EAW82304.1.
AF321824 mRNA. Translation: AAK01642.1.
CCDSiCCDS6389.1.
RefSeqiNP_076435.1. NM_023946.3. [P0DP58-2]
NP_803252.1. NM_177457.4. [P0DP58-1]
NP_803429.1. NM_177476.3. [P0DP58-1]
NP_803430.1. NM_177477.3. [P0DP58-1]
UniGeneiHs.158665.
Hs.604828.

Genome annotation databases

EnsembliENST00000614491; ENSP00000477648; ENSG00000180155. [P0DP58-1]
ENST00000620006; ENSP00000478402; ENSG00000180155. [P0DP58-1]
ENST00000621401; ENSP00000478390; ENSG00000180155. [P0DP58-1]
GeneIDi111188157.
66004.
KEGGihsa:111188157.
hsa:66004.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLYNX1_HUMAN
AccessioniPrimary (citable) accession number: P0DP58
Secondary accession number(s): A0A140VJN6
, D3DWI7, G3XAC2, Q86SR0, Q9BZG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2017
Last sequence update: July 5, 2017
Last modified: February 28, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome