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Protein

Calmodulin-1

Gene

calm1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases.

Miscellaneous

This protein has four functional calcium-binding sites.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 321Add BLAST12
Calcium bindingi57 – 682Add BLAST12
Calcium bindingi94 – 1053Add BLAST12
Calcium bindingi130 – 1414Add BLAST12

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • receptor binding Source: BHF-UCL

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-1By similarity
Gene namesi
Name:calm1By similarity
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-976648. calm1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00004399442 – 149Calmodulin-1Add BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei116N6,N6,N6-trimethyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Interactioni

GO - Molecular functioni

  • receptor binding Source: BHF-UCL

Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 9Combined sources3
Helixi12 – 20Combined sources9
Beta strandi23 – 25Combined sources3
Helixi30 – 38Combined sources9
Turni39 – 41Combined sources3
Helixi46 – 56Combined sources11
Beta strandi59 – 64Combined sources6
Helixi68 – 78Combined sources11
Beta strandi79 – 83Combined sources5
Helixi84 – 92Combined sources9
Beta strandi98 – 102Combined sources5
Helixi105 – 113Combined sources9
Helixi119 – 128Combined sources10
Helixi139 – 145Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CFCNMR-A2-149[»]
1CFDNMR-A2-149[»]
1CFFNMR-A2-149[»]
1CKKNMR-A2-149[»]
1DMONMR-A2-149[»]
1F70NMR-A2-77[»]
1F71NMR-A83-149[»]
1IQ5X-ray1.80A1-149[»]
1MUXNMR-A2-149[»]
1NWDNMR-A2-149[»]
1SY9NMR-A2-149[»]
1X02NMR-A2-149[»]
1Y0VX-ray3.60H/I/J/K/L/M6-149[»]
2COLX-ray2.20B80-146[»]
2K3SNMR-B83-149[»]
2KDUNMR-A2-149[»]
2LLONMR-A2-81[»]
2LLQNMR-A83-149[»]
2MESNMR-A2-149[»]
2RRTNMR-A79-149[»]
4R8GX-ray3.50A/B/H2-149[»]
5J7JNMR-A2-149[»]
5T0XNMR-A2-149[»]
SMRiP0DP33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 116EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini117 – 149EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the calmodulin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK02183.

Family and domain databases

CDDicd00051. EFh. 2 hits.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PfamiView protein in Pfam
PF13499. EF-hand_7. 2 hits.
SMARTiView protein in SMART
SM00054. EFh. 4 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DP33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY
110 120 130 140
ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK
Length:149
Mass (Da):16,838
Last modified:May 10, 2017 - v1
Checksum:i6B4BC3FCDE10727B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094079 mRNA. Translation: AAH94079.1.
PIRiI51402.
RefSeqiNP_001080864.1. NM_001087395.1.
NP_001084025.1. NM_001090556.1.
NP_001089059.1. NM_001095590.1.
XP_018085904.1. XM_018230415.1.
UniGeneiXl.54061.
Xl.543.
Xl.54419.

Genome annotation databases

GeneIDi108698710.
380558.
399259.
606721.
KEGGixla:108698710.
xla:380558.
xla:399259.
xla:606721.

Similar proteinsi

Entry informationi

Entry nameiCALM1_XENLA
AccessioniPrimary (citable) accession number: P0DP33
Secondary accession number(s): P02593
, P0DP40, P62155, P70667, P99014, Q61379, Q61380, Q6INP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2017
Last sequence update: May 10, 2017
Last modified: January 31, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families