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Protein

50S ribosomal protein L6

Gene

rplF

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L6UniRule annotation
Gene namesi
Name:rplFUniRule annotation
Ordered Locus Names:TTHA1677
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001310722 – 18050S ribosomal protein L6Add BLAST179

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit.

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 28Combined sources8
Beta strandi31 – 36Combined sources6
Beta strandi47 – 49Combined sources3
Helixi59 – 79Combined sources21
Beta strandi86 – 93Combined sources8
Beta strandi95 – 99Combined sources5
Beta strandi102 – 106Combined sources5
Beta strandi108 – 111Combined sources4
Beta strandi113 – 115Combined sources3
Beta strandi121 – 124Combined sources4
Beta strandi126 – 138Combined sources13
Helixi139 – 150Combined sources12
Beta strandi161 – 163Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VVJX-ray3.44RH/YH1-180[»]
1VY4X-ray2.60BH/DH1-180[»]
1VY5X-ray2.55BH/DH1-180[»]
1VY6X-ray2.90BH/DH1-180[»]
1VY7X-ray2.80BH/DH1-180[»]
4L47X-ray3.22RH/YH1-180[»]
4L71X-ray3.90RH/YH1-180[»]
4LELX-ray3.90RH/YH1-180[»]
4LFZX-ray3.92RH/YH1-180[»]
4LNTX-ray2.94RH/YH1-180[»]
4LSKX-ray3.48RH/YH1-180[»]
4LT8X-ray3.14RH/YH1-180[»]
4P6FX-ray3.60RH/YH1-180[»]
4P70X-ray3.68RH/YH1-180[»]
4TUAX-ray3.60RH/YH1-180[»]
4TUBX-ray3.60RH/YH1-180[»]
4TUCX-ray3.60RH/YH1-180[»]
4TUDX-ray3.60RH/YH1-180[»]
4TUEX-ray3.50RH/YH1-180[»]
4V42X-ray5.50BH26-177[»]
4V4PX-ray5.50H24-177[»]
4V4XX-ray5.00BH1-180[»]
4V4YX-ray5.50BH1-180[»]
4V4ZX-ray4.51BH1-180[»]
4V51X-ray2.80BH/DH2-180[»]
4V5AX-ray3.50BH/DH2-180[»]
4V5CX-ray3.30BH/DH1-180[»]
4V5DX-ray3.50BH/DH1-180[»]
4V5EX-ray3.45BH/DH1-180[»]
4V5FX-ray3.60BH/DH1-180[»]
4V5GX-ray3.60BH/DH1-180[»]
4V5JX-ray3.10BH/DH1-180[»]
4V5KX-ray3.20BH/DH1-180[»]
4V5LX-ray3.10BH1-180[»]
4V5Melectron microscopy7.80BH1-180[»]
4V5Nelectron microscopy7.60BH1-180[»]
4V5PX-ray3.10BH/DH1-180[»]
4V5QX-ray3.10BH/DH1-180[»]
4V5RX-ray3.10BH/DH1-180[»]
4V5SX-ray3.10BH/DH1-180[»]
4V68electron microscopy6.40BH12-171[»]
4V6AX-ray3.10BH/DH1-180[»]
4V6FX-ray3.10AH/DH1-180[»]
4V6GX-ray3.50BH/DH1-180[»]
4V7JX-ray3.30AH/BH1-180[»]
4V7KX-ray3.60AH/BH1-180[»]
4V7LX-ray3.00BH/DH1-180[»]
4V7MX-ray3.45BH/DH1-180[»]
4V7WX-ray3.00BH/DH1-180[»]
4V7XX-ray3.00BH/DH1-180[»]
4V7YX-ray3.00BH/DH1-180[»]
4V7ZX-ray3.10BH/DH1-180[»]
4V87X-ray3.10AH/DH2-171[»]
4V8AX-ray3.20AH/BH1-180[»]
4V8BX-ray3.00BH/DH1-180[»]
4V8CX-ray3.30AH/BH1-180[»]
4V8DX-ray3.00BH/DH1-180[»]
4V8EX-ray3.30AH/CH1-180[»]
4V8FX-ray3.30AH/DH1-180[»]
4V8GX-ray3.00BH/DH1-180[»]
4V8HX-ray3.10BH/DH1-180[»]
4V8IX-ray2.70BH/DH1-180[»]
4V8JX-ray3.90BH/DH1-180[»]
4V8NX-ray3.10BH/DH1-180[»]
4V8OX-ray3.80BH1-180[»]
4V8QX-ray3.10AH1-180[»]
4V8UX-ray3.70BH/DH1-180[»]
4V8XX-ray3.35BH/DH1-180[»]
4V90X-ray2.95BH1-180[»]
4V95X-ray3.20BH/DH1-180[»]
4V97X-ray3.52BH/DH1-180[»]
4V9AX-ray3.30BH/DH1-180[»]
4V9BX-ray3.10BH/DH1-180[»]
4V9HX-ray2.86BH1-180[»]
4V9IX-ray3.30BH/DH12-170[»]
4V9RX-ray3.00BH/DH1-180[»]
4V9SX-ray3.10BH/DH1-180[»]
4W2EX-ray2.90H1-180[»]
4W2FX-ray2.40BH/DH1-180[»]
4W2GX-ray2.55BH/DH1-180[»]
4W2HX-ray2.70BH/DH1-180[»]
4W2IX-ray2.70BH/DH1-180[»]
4W4GX-ray3.30RH/YH1-180[»]
4WPOX-ray2.80AH/CH1-180[»]
4WQ1X-ray3.1051/591-180[»]
4WQFX-ray2.80AH/CH1-180[»]
4WQRX-ray3.1551/591-180[»]
4WQUX-ray2.80AH/CH1-180[»]
4WQYX-ray2.80AH/CH1-180[»]
4WR6X-ray3.0551/591-180[»]
4WRAX-ray3.0551/591-180[»]
4WROX-ray3.05511-180[»]
4WSDX-ray2.9551/591-180[»]
4WSMX-ray3.3051/591-180[»]
4WT1X-ray3.0551/591-180[»]
4WT8X-ray3.40CF/DF12-170[»]
4WU1X-ray3.2051/591-180[»]
4WZDX-ray3.1051/591-180[»]
4WZOX-ray3.3051/591-180[»]
4Y4OX-ray2.301H/2H1-180[»]
4Y4PX-ray2.501H/2H1-180[»]
4YPBX-ray3.40RH/YH1-180[»]
4YZVX-ray3.10RH/YH1-180[»]
4Z3SX-ray2.651H/2H1-180[»]
4Z8CX-ray2.901H/2H1-180[»]
4ZERX-ray3.101H/2H2-175[»]
4ZSNX-ray3.60RH/YH1-180[»]
5A9Zelectron microscopy4.70AH4-177[»]
5AA0electron microscopy5.00AH4-177[»]
5CZPX-ray3.30RH/YH1-180[»]
5D8BX-ray3.63AB/E1-180[»]
5DFEX-ray3.10RH/YH1-180[»]
5DOXX-ray3.101H/2H1-180[»]
5DOYX-ray2.601H/2H1-180[»]
5E7KX-ray3.2051/591-180[»]
5E81X-ray2.9551/591-180[»]
5EL4X-ray3.1551/591-180[»]
5EL5X-ray3.1551/591-180[»]
5EL6X-ray3.1051/591-180[»]
5EL7X-ray3.1551/591-180[»]
5F8KX-ray2.801H/2H2-175[»]
5FDUX-ray2.901H/2H2-175[»]
5FDVX-ray2.801H/2H2-175[»]
5HAUX-ray3.001H/2H1-180[»]
5HCPX-ray2.891H/2H1-180[»]
5HCQX-ray2.801H/2H1-180[»]
5HCRX-ray2.801H/2H1-180[»]
5HD1X-ray2.701H/2H1-180[»]
5IB7X-ray2.9951/591-180[»]
5IB8X-ray3.1351/591-180[»]
5IBBX-ray2.9651/591-180[»]
5IMQelectron microscopy3.80e1-180[»]
5IMRelectron microscopy-e1-180[»]
5J30X-ray3.20RH/YH1-180[»]
5J3CX-ray3.04RH/YH1-180[»]
5J4BX-ray2.601H/2H1-180[»]
5J4CX-ray2.801H/2H1-180[»]
5J8BX-ray2.60H1-180[»]
5NDKX-ray2.9551/591-180[»]
5OT7electron microscopy3.80k1-176[»]
5VP2X-ray2.801H/2H1-180[»]
5W4KX-ray2.701H/2H1-180[»]
5WISX-ray2.701H/2H1-180[»]
5WITX-ray2.601H/2H1-180[»]
6C5LX-ray3.20BH/DH1-180[»]
6CFJX-ray2.801H/2H1-180[»]
6CFKX-ray2.701H/2H1-180[»]
6CFLX-ray2.601H/2H1-180[»]
6FKRX-ray3.201H/2H2-175[»]
SMRiP0DOY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the universal ribosomal protein uL6 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108R5J Bacteria
COG0097 LUCA
HOGENOMiHOG000039903
KOiK02933
OMAiINNMVVG
PhylomeDBiQ5SHQ3

Family and domain databases

Gene3Di3.90.930.12, 2 hits
HAMAPiMF_01365_B Ribosomal_L6_B, 1 hit
InterProiView protein in InterPro
IPR000702 Ribosomal_L6
IPR020040 Ribosomal_L6_a/b-dom
IPR036789 Ribosomal_L6_a/b-dom_sf
IPR019906 Ribosomal_L6_bac-type
PANTHERiPTHR11655 PTHR11655, 1 hit
PTHR11655:SF14 PTHR11655:SF14, 1 hit
PfamiView protein in Pfam
PF00347 Ribosomal_L6, 2 hits
PIRSFiPIRSF002162 Ribosomal_L6, 1 hit
PRINTSiPR00059 RIBOSOMALL6
SUPFAMiSSF56053 SSF56053, 2 hits
TIGRFAMsiTIGR03654 L6_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DOY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRIGRLPIP VPKGVSVEVA PGRVKVKGPK GELEVPVSPE MRVVVEEGVV
60 70 80 90 100
RVERPSDERR HKSLHGLTRT LIANAVKGVS EGYSKELLIK GIGYRARLVG
110 120 130 140 150
RALELTVGFS HPVVVEPPEG ITFEVPEPTR VRVSGIDKQK VGQVAANIRA
160 170 180
IRKPSAYHEK GIYYAGEPVR LKPGKAGAKK
Length:180
Mass (Da):19,532
Last modified:March 15, 2017 - v1
Checksum:i1913833C0C30E95D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19 – 20VA → AV AA sequence (PubMed:11154066).Curated2
Sequence conflicti25K → L AA sequence (PubMed:11154066).Curated1
Sequence conflicti27K → Y AA sequence (PubMed:11154066).Curated1

Mass spectrometryi

Molecular mass is 19401 Da from positions 2 - 180. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA Translation: BAD71500.1
PIRiS15442
RefSeqiWP_011173704.1, NC_006461.1
YP_144943.1, NC_006461.1

Genome annotation databases

GeneIDi3169807
KEGGittj:TTHA1677

Similar proteinsi

Entry informationi

Entry nameiRL6_THET8
AccessioniPrimary (citable) accession number: P0DOY8
Secondary accession number(s): Q5SHQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2017
Last sequence update: March 15, 2017
Last modified: May 23, 2018
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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