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Protein

Immunoglobulin lambda constant 2

Gene

IGLC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).3 Publications

Miscellaneous

Displays the following serological isotype: Mcg-, Kern- and Oz-. The Mcg- isotype marker is characterized by Ala-6, Ser-8 and Thr-57; the Ke- marker by Ser-46 and the Oz- marker by Arg-83.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionBence-Jones protein
Biological processAdaptive immunity, Immunity

Protein family/group databases

IMGT/GENE-DBIGLC2.

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin lambda constant 22 Publications
Alternative name(s):
Ig lambda chain C region Kern1 Publication
Ig lambda chain C region NIG-641 Publication
Ig lambda chain C region SH1 Publication
Ig lambda chain C region X1 Publication
Ig lambda-2 chain C regionCurated
Gene namesi
Name:IGLC22 Publications
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000211677.2.
HGNCiHGNC:5856. IGLC2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi298351714.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000394665‹1 – 106Immunoglobulin lambda constant 2Add BLAST›106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 87PROSITE-ProRule annotation
Disulfide bondi105Interchain (with heavy chain)1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP0DOY2.
PRIDEiP0CG05.

Expressioni

Gene expression databases

BgeeiENSG00000211677.

Interactioni

Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

Structurei

Secondary structure

1106
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 12Combined sources5
Helixi16 – 20Combined sources5
Beta strandi24 – 36Combined sources13
Beta strandi39 – 44Combined sources6
Beta strandi47 – 49Combined sources3
Beta strandi53 – 55Combined sources3
Beta strandi62 – 64Combined sources3
Beta strandi66 – 74Combined sources9
Helixi76 – 81Combined sources6
Beta strandi85 – 91Combined sources7
Beta strandi94 – 100Combined sources7
Helixi102 – 104Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JVKX-ray1.94B1-105[»]
1LILX-ray2.65A/B1-106[»]
1ZVOX-ray-A/B2-106[»]
2JB5X-ray2.80L1-104[»]
2JB6X-ray2.85A/L1-104[»]
3C2AX-ray2.10L/M2-105[»]
3TV3X-ray1.29L1-106[»]
3TWCX-ray1.65L1-106[»]
3TYGX-ray3.25L1-106[»]
4EOWX-ray1.97L1-106[»]
4LLDX-ray1.19B1-105[»]
4LLMX-ray1.75B1-105[»]
4LLQX-ray1.42B1-105[»]
4LLUX-ray2.16B/D1-105[»]
4LLWX-ray1.95B/D1-105[»]
4LLYX-ray1.60B/D1-105[»]
4O58X-ray2.75L1-106[»]
4O5IX-ray6.50N/P/R/T/V/X1-106[»]
5IQ7X-ray3.29L1-104[»]
5IQ9X-ray2.40B/L1-102[»]
SMRiP0DOY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 101Ig-likePROSITE-ProRule annotationAdd BLAST95

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

eggNOGiENOG410J0XA. Eukaryota.
ENOG410YZ00. LUCA.
InParanoidiP0CG05.
PhylomeDBiP0CG05.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

P0DOY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GQPKAAPSVT LFPPSSEELQ ANKATLVCLI SDFYPGAVTV AWKADSSPVK
60 70 80 90 100
AGVETTTPSK QSNNKYAASS YLSLTPEQWK SHRSYSCQVT HEGSTVEKTV

APTECS
Length:106
Mass (Da):11,294
Last modified:March 15, 2017 - v1
Checksum:iE5DB72BBE65F4577
GO

Sequence cautioni

The sequence AAA59107 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA20026 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA36049 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB38569 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW59547 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW59549 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Polymorphismi

There are several alleles. The sequence shown is that of IMGT allele IGLC2*02.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00253 Genomic DNA. Translation: AAA59107.1. Different initiation.
X51754 Genomic DNA. Translation: CAB38569.1. Different initiation.
X51755 Genomic DNA. Translation: CAA36049.1. Different initiation.
D87023 Genomic DNA. Translation: BAA20026.1. Different initiation.
AC245028 Genomic DNA. No translation available.
CH471095 Genomic DNA. Translation: EAW59547.1. Different initiation.
CH471095 Genomic DNA. Translation: EAW59549.1. Different initiation.
PIRiA92057. L2HU.

Genome annotation databases

EnsembliENST00000390323; ENSP00000374856; ENSG00000211677.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIGLC2_HUMAN
AccessioniPrimary (citable) accession number: P0DOY2
Secondary accession number(s): A0A075B6K9
, A0M8Q4, P0CG05, P0CG06, P80423
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2017
Last sequence update: March 15, 2017
Last modified: October 25, 2017
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

For an example of a full-length immunoglobulin lambda light chain see AC P0DOX8.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references