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Protein

Immunoglobulin lambda-1 light chain

Gene
N/A
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin lambda-1 light chainCurated
Alternative name(s):
Immunoglobulin lambda-1 light chain MCG1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004392891 – 216Immunoglobulin lambda-1 light chainAdd BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi22 ↔ 90PROSITE-ProRule annotation
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi138 ↔ 197PROSITE-ProRule annotation
Disulfide bondi215Interchain (with heavy chain)Curated

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Interactioni

Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

Structurei

3D structure databases

SMRiP0DOX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 108Ig-like 1PROSITE-ProRule annotationAdd BLAST108
Domaini117 – 211Ig-like 2PROSITE-ProRule annotationAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 111Variable (V) domain, involved in antigen recognitionCuratedAdd BLAST111
Regioni112 – 216Constant (C) domainCuratedAdd BLAST105

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Immunoglobulin V region

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SM00407. IGc1. 1 hit.
SM00406. IGv. 1 hit.
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 2 hits.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

P0DOX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QSALTQPPSA SGSLGQSVTI SCTGTSSDVG GYNYVSWYQQ HAGKAPKVII
60 70 80 90 100
YEVNKRPSGV PDRFSGSKSG NTASLTVSGL QAEDEADYYC SSYEGSDNFV
110 120 130 140 150
FGTGTKVTVL GQPKANPTVT LFPPSSEELQ ANKATLVCLI SDFYPGAVTV
160 170 180 190 200
AWKADGSPVK AGVETTKPSK QSNNKYAASS YLSLTPEQWK SHRSYSCQVT
210
HEGSTVEKTV APTECS
Length:216
Mass (Da):22,830
Last modified:March 15, 2017 - v1
Checksum:i6B8F588742273FDA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Similar proteinsi

Entry informationi

Entry nameiIGL1_HUMAN
AccessioniPrimary (citable) accession number: P0DOX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2017
Last sequence update: March 15, 2017
Last modified: October 25, 2017
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

This sequence is an example of a full-length immunoglobulin lambda-1 light chain.Curated

Keywords - Technical termi

Direct protein sequencing