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Protein

Immunoglobulin mu heavy chain

Gene
N/A
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B cell receptor, the secreted form is secreted in large amounts (PubMed:3137579, PubMed:16895553).4 Publications1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin mu heavy chainCurated
Alternative name(s):
Immunoglobulin mu heavy chain OU1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004392861 – 576Immunoglobulin mu heavy chainAdd BLAST576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi22 ↔ 971 Publication
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi140Interchain (with light chain)1 Publication
Disulfide bondi153 ↔ 2121 Publication
Glycosylationi170N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi259 ↔ 3201 Publication
Glycosylationi332N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi337Interchain (with heavy chain)1 Publication
Disulfide bondi367 ↔ 4261 Publication
Glycosylationi395N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi402N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi474 ↔ 5361 Publication
Glycosylationi563N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi575Interchain (with heavy chain)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

PTM databases

iPTMnetiP0DOX6.

Interactioni

Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked (PubMed:20176268). It is found almost exclusively as a homopentamer in the serum. Membrane-bound IgM molecules are non-covalently associated with heterodimer of CD79A and CD79B (PubMed:16895553).2 Publications

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 97Ig-like 1PROSITE-ProRule annotationAdd BLAST97
Domaini132 – 212Ig-like 2PROSITE-ProRule annotationAdd BLAST81
Domaini236 – 334Ig-like 3PROSITE-ProRule annotationAdd BLAST99
Domaini352 – 442Ig-like 4PROSITE-ProRule annotationAdd BLAST91
Domaini452 – 553Ig-like 5PROSITE-ProRule annotationAdd BLAST102

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 124Variable (V) domain, involved in antigen recognition1 PublicationAdd BLAST124
Regioni125 – 576Constant (C) domain1 PublicationAdd BLAST452

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Immunoglobulin V region, Repeat

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF07654. C1-set. 4 hits.
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SM00407. IGc1. 4 hits.
SM00406. IGv. 1 hit.
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 5 hits.
PS00290. IG_MHC. 3 hits.

Sequencei

Sequence statusi: Complete.

P0DOX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QVTLTESGPA LVKPKQPLTL TCTFSGFSLS TSRMRVSWIR RPPGKALEWL
60 70 80 90 100
ARIDDDDKFY WSTSLRTRLS ISKNDSKNQV VLIMINVNPV DTATYYCARV
110 120 130 140 150
VNSVMAGYYY YYMDVWGKGT TVTVSSGSAS APTLFPLVSC ENSBPSSTVA
160 170 180 190 200
VGCLAQDFLP DSITFSWKYN QSQKISSTRG FPSVLRGGKY AATSQVLLPS
210 220 230 240 250
KDVMQGTDEH VCKWVQHPNG NKQKNVPLPV IAELPPKVSV FVPPRDGFFG
260 270 280 290 300
NPRKSKLICQ ATGFSPRQVW SLREGKQVGS GVTTDQVQAE AKESGPTTYK
310 320 330 340 350
VTSTLTIKES DWLGESMFTC RVDHRGLTFQ QNASSMCVPD QDTAIRVFAI
360 370 380 390 400
PPSFASIFLT KSTKLTCLVT DLTTYDSVTI SWTREENGAV KTHTNISESH
410 420 430 440 450
PNATFSAVGE ASICEDDDWS GERFTCTVTH TDLPSPLKQT ISRPKGVALH
460 470 480 490 500
RPDVYLLPPA REQLNLRESA TITCLVTGFS PADVFVQWMQ RGEPLSPEKY
510 520 530 540 550
VTSAPMPEPQ APGRYFAHSI LTVSEEEWNT GQTYTCVVAH EALPNRVTER
560 570
TVDKSTGKPT LYNVSLVMSD TAGTCY
Length:576
Mass (Da):63,486
Last modified:March 15, 2017 - v1
Checksum:iAEA9AA38C1A05D23
GO

Similar proteinsi

Entry informationi

Entry nameiIGM_HUMAN
AccessioniPrimary (citable) accession number: P0DOX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2017
Last sequence update: March 15, 2017
Last modified: October 25, 2017
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

This sequence is an example of a full-length immunoglobulin mu heavy chain.Curated

Keywords - Technical termi

Direct protein sequencing