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Protein

Immunoglobulin gamma-1 heavy chain

Gene
N/A
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin gamma-1 heavy chainCurated
Alternative name(s):
Immunoglobulin gamma-1 heavy chain NIE1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004392871 – 449Immunoglobulin gamma-1 heavy chainAdd BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi22 ↔ 961 Publication
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi146 ↔ 2021 Publication
Disulfide bondi222Interchain (with light chain)1 Publication
Disulfide bondi228Interchain (with heavy chain)1 Publication
Disulfide bondi231Interchain (with heavy chain)1 Publication
Disulfide bondi263 ↔ 3231 Publication
Glycosylationi299N-linked (GlcNAc...) (complex) asparagine1 Publication1
Disulfide bondi369 ↔ 4271 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

PTM databases

iPTMnetiP0DOX5.

Interactioni

Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

Structurei

Secondary structure

1449
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Beta strandi10 – 12Combined sources3
Beta strandi18 – 27Combined sources10
Helixi29 – 31Combined sources3
Beta strandi34 – 39Combined sources6
Beta strandi46 – 51Combined sources6
Beta strandi53 – 55Combined sources3
Turni62 – 64Combined sources3
Beta strandi68 – 73Combined sources6
Turni74 – 77Combined sources4
Beta strandi78 – 83Combined sources6
Helixi88 – 90Combined sources3
Beta strandi92 – 97Combined sources6
Beta strandi113 – 117Combined sources5
Beta strandi126 – 130Combined sources5
Beta strandi134 – 136Combined sources3
Beta strandi141 – 154Combined sources14
Beta strandi157 – 160Combined sources4
Turni161 – 164Combined sources4
Beta strandi169 – 171Combined sources3
Beta strandi182 – 191Combined sources10
Helixi192 – 194Combined sources3
Turni195 – 197Combined sources3
Beta strandi201 – 206Combined sources6
Helixi207 – 209Combined sources3
Beta strandi211 – 216Combined sources6
Beta strandi241 – 245Combined sources5
Helixi249 – 253Combined sources5
Beta strandi255 – 257Combined sources3
Beta strandi260 – 268Combined sources9
Beta strandi270 – 272Combined sources3
Beta strandi276 – 281Combined sources6
Beta strandi284 – 286Combined sources3
Beta strandi289 – 291Combined sources3
Beta strandi295 – 297Combined sources3
Turni298 – 300Combined sources3
Beta strandi302 – 309Combined sources8
Helixi312 – 316Combined sources5
Beta strandi321 – 326Combined sources6
Beta strandi330 – 332Combined sources3
Beta strandi334 – 338Combined sources5
Beta strandi349 – 353Combined sources5
Helixi357 – 361Combined sources5
Beta strandi362 – 377Combined sources16
Beta strandi380 – 385Combined sources6
Beta strandi388 – 390Combined sources3
Beta strandi393 – 395Combined sources3
Beta strandi406 – 415Combined sources10
Helixi416 – 420Combined sources5
Beta strandi425 – 430Combined sources6
Helixi435 – 437Combined sources3
Beta strandi438 – 443Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5O4EX-ray2.15A227-449[»]
B/D227-449[»]
C227-448[»]
5VJ6electron microscopy11.50H3-224[»]
5VZXX-ray2.50E/H1-227[»]
5VZYX-ray2.32H1-227[»]
5W5LX-ray1.90A/B227-449[»]
5Y56X-ray2.65A/B238-445[»]
SMRiP0DOX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 96Ig-like 1PROSITE-ProRule annotationAdd BLAST96
Domaini125 – 218Ig-like 2PROSITE-ProRule annotationAdd BLAST94
Domaini240 – 339Ig-like 3PROSITE-ProRule annotationAdd BLAST100
Domaini348 – 444Ig-like 4PROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 119Variable (V) domain, involved in antigen recognitionCuratedAdd BLAST119
Regioni120 – 449Constant (C) domainCuratedAdd BLAST330

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Immunoglobulin V region, Repeat

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF07654. C1-set. 3 hits.
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SM00407. IGc1. 3 hits.
SM00406. IGv. 1 hit.
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 4 hits.
PS00290. IG_MHC. 2 hits.

Sequencei

Sequence statusi: Complete.

P0DOX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QVQLVQSGGG VVQPGRSLRL SCAASGFTFS RYTIHWVRQA PGKGLEWVAV
60 70 80 90 100
MSYBGBBKHY ADSVNGRFTI SRNDSKNTLY LNMNSLRPED TAVYYCARIR
110 120 130 140 150
DTAMFFAHWG QGTLVTVSSA STKGPSVFPL APSSKSTSGG TAALGCLVKD
160 170 180 190 200
YFPEPVTVSW NSGALTSGVH TFPAVLQSSG LYSLSSVVTV PSSSLGTQTY
210 220 230 240 250
ICNVNHKPSN TKVDKKVEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK
260 270 280 290 300
DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS
310 320 330 340 350
TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV
360 370 380 390 400
YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL
410 420 430 440
DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
Length:449
Mass (Da):49,330
Last modified:March 15, 2017 - v1
Checksum:iA3E081C00BDF6532
GO

Similar proteinsi

Entry informationi

Entry nameiIGG1_HUMAN
AccessioniPrimary (citable) accession number: P0DOX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2017
Last sequence update: March 15, 2017
Last modified: November 22, 2017
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

This sequence is an example of a full-length immunoglobulin gamma-1 heavy chain.Curated

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references