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Protein

Immunoglobulin delta heavy chain

Gene
N/A
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). IgD is the major antigen receptor isotype on the surface of most peripheral B cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum is below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD (PubMed:8774350, PubMed:11282392, PubMed:10702483, PubMed:16895553).6 Publications1 Publication

GO - Molecular functioni

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • monocyte activation Source: UniProtKB
  • positive regulation of interleukin-1 beta secretion Source: UniProtKB
  • positive regulation of interleukin-1 secretion Source: UniProtKB
  • positive regulation of tumor necrosis factor secretion Source: UniProtKB

Keywordsi

Biological processAdaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin delta heavy chainCurated
Alternative name(s):
Immunoglobulin delta heavy chain WAH1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004392841 – 512Immunoglobulin delta heavy chainAdd BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 971 PublicationPROSITE-ProRule annotation
Disulfide bondi144Interchain (with light chain)1 PublicationPROSITE-ProRule annotation
Disulfide bondi157 ↔ 2131 PublicationPROSITE-ProRule annotation
Glycosylationi238O-linked (GalNAc...) serine1 Publication1
Glycosylationi255O-linked (GalNAc...) threonine1 Publication1
Glycosylationi256O-linked (GalNAc...) threonine1 Publication1
Glycosylationi260O-linked (GalNAc...) threonine1 Publication1
Glycosylationi261O-linked (GalNAc...) threonine1 Publication1
Disulfide bondi290Interchain (with heavy chain)1 PublicationPROSITE-ProRule annotation
Disulfide bondi319 ↔ 3781 PublicationPROSITE-ProRule annotation
Glycosylationi354N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi423 ↔ 4841 PublicationPROSITE-ProRule annotation
Glycosylationi445N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi496N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

PTM databases

iPTMnetiP0DOX3.

Interactioni

Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked (PubMed:20176268). An IgD molecule contains thus a delta heavy chain combined with either a kappa or a lambda light chains. Kappa light chains are found predominantly on the membrane IgD (mIgD) form and lambda on the secreted IgD (sIgD) form, this fact is poorly understood. Membrane-bound IgD molecules are non-covalently associated with a heterodimer of CD79A and CD79B (PubMed:11282392, PubMed:16895553).3 Publications

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZVOX-ray-C/D1-512[»]
SMRiP0DOX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 97Ig-like 1PROSITE-ProRule annotationAdd BLAST97
Domaini135 – 227Ig-like 2PROSITE-ProRule annotationAdd BLAST93
Domaini304 – 392Ig-like 3PROSITE-ProRule annotationAdd BLAST89
Domaini396 – 502Ig-like 4PROSITE-ProRule annotationAdd BLAST107

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 129Variable (V) domain, involved in antigen recognition1 PublicationAdd BLAST129
Regioni130 – 512Constant (C) domain1 PublicationAdd BLAST383

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Immunoglobulin V region

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
PfamiView protein in Pfam
PF07654. C1-set. 2 hits.
PF00047. ig. 1 hit.
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SM00407. IGc1. 3 hits.
SM00406. IGv. 1 hit.
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 4 hits.
PS00290. IG_MHC. 2 hits.

Sequencei

Sequence statusi: Complete.

P0DOX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RLQLQESGPG LVKPSETLSL TCIVSGGPIR RTGYYWGWIR QPPGKGLEWI
60 70 80 90 100
GGVYYTGSIY YNPSLRGRVT ISVDTSRNQF SLNLRSMSAA DTAMYYCARG
110 120 130 140 150
NPPPYYDIGT GSDDGIDVWG QGTTVHVSSA PTKAPDVFPI ISGCRHPKDN
160 170 180 190 200
SPVVLACLIT GYHPTSVTVT WYMGTQSQPQ RTFPEIQRRD SYYMTSSQLS
210 220 230 240 250
TPLQQWRQGE YKCVVQHTAS KSKKEIFRWP ESPKAQASSV PTAQPQAEGS
260 270 280 290 300
LAKATTAPAT TRNTGRGGEE KKKEKEKEEQ EERETKTPEC PSHTQPLGVY
310 320 330 340 350
LLTPAVQDLW LRDKATFTCF VVGSDLKDAH LTWEVAGKVP TGGVEEGLLE
360 370 380 390 400
RHSNGSQSQH SRLTLPRSLW NAGTSVTCTL NHPSLPPQRL MALREPAAQA
410 420 430 440 450
PVKLSLNLLA SSDPPEAASW LLCEVSGFSP PNILLMWLED QREVNTSGFA
460 470 480 490 500
PARPPPQPGS TTFWAWSVLR VPAPPSPQPA TYTCVVSHED SRTLLNASRS
510
LEVSYVTDHG PM
Length:512
Mass (Da):56,224
Last modified:March 15, 2017 - v1
Checksum:i74FBAD9F87EDE94C
GO

Entry informationi

Entry nameiIGD_HUMAN
AccessioniPrimary (citable) accession number: P0DOX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2017
Last sequence update: March 15, 2017
Last modified: October 25, 2017
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

This sequence is an example of a full-length immunoglobulin delta heavy chain.Curated

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references