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Protein

Immunoglobulin alpha-2 heavy chain

Gene
N/A
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin alpha-2 heavy chainCurated
Alternative name(s):
Immunoglobulin alpha-2 heavy chain BUT1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004392831 – 455Immunoglobulin alpha-2 heavy chainAdd BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 951 PublicationPROSITE-ProRule annotation
Disulfide bondi141 ↔ 2001 PublicationPROSITE-ProRule annotation
Glycosylationi162N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi207N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi216Interchain (with light chain)1 Publication
Disulfide bondi224Interchain (with heavy chain)1 Publication
Disulfide bondi225 ↔ 2821 Publication
Glycosylationi246N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi249 ↔ 3061 PublicationPROSITE-ProRule annotation
Disulfide bondi284Interchain (with heavy chain)1 Publication
Disulfide bondi294Interchain (with heavy chain of another subunit)1 Publication
Glycosylationi320N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi352 ↔ 4151 PublicationPROSITE-ProRule annotation
Glycosylationi442N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi454Interchain (with J chain)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

PTM databases

iPTMnetiP0DOX2.

Interactioni

Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked (PubMed:20176268). Monomeric or polymeric (PubMed:2241915).2 Publications

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 95Ig-like 1PROSITE-ProRule annotationAdd BLAST95
Domaini121 – 213Ig-like 2PROSITE-ProRule annotationAdd BLAST93
Domaini227 – 322Ig-like 3PROSITE-ProRule annotationAdd BLAST96
Domaini330 – 432Ig-like 4PROSITE-ProRule annotationAdd BLAST103

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 115Variable (V) domain, involved in antigen recognition1 PublicationAdd BLAST115
Regioni116 – 455Constant (C) domain1 PublicationAdd BLAST340

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi215 – 227Pro-richPROSITE-ProRule annotationAdd BLAST13

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Immunoglobulin V region, Repeat

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
PfamiView protein in Pfam
PF07654. C1-set. 2 hits.
PF00047. ig. 1 hit.
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 4 hits.
SM00407. IGc1. 3 hits.
SM00406. IGv. 1 hit.
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 4 hits.
PS00290. IG_MHC. 2 hits.

Sequencei

Sequence statusi: Complete.

P0DOX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EVQLVETGGG LIQPGGSLRL SCAASGFTVS BHSMSWVRQA PGKALZWVSA
60 70 80 90 100
IYRGGTTYYA DSVKGRFTIS RDDSRBTVYL QMBSLRAEDT AVYYCARDLA
110 120 130 140 150
AARLFGKGTT VTVSSASPTS PKVFPLSLDS TPQDGNVVVA CLVQGFFPQE
160 170 180 190 200
PLSVTWSESG QNVTARNFPP SQDASGDLYT TSSQLTLPAT QCPDGKSVTC
210 220 230 240 250
HVKHYTNSSQ DVTVPCRVPP PPPCCHPRLS LHRPALEDLL LGSEANLTCT
260 270 280 290 300
LTGLRDASGA TFTWTPSSGK SAVEGPPERD LCGCYSVSSV LPGCAQPWNH
310 320 330 340 350
GETFTCTAAH PELKTPLTAN ITKSGNTFRP EVHLLPPPSE ELALNELVTL
360 370 380 390 400
TCLARGFSPK DVLVRWLQGS QELPREKYLT WASRQEPSQG TTTYAVTSIL
410 420 430 440 450
RVAAEDWKKG ETFSCMVGHE ALPLAFTQKT IDRLAGKPTH INVSVVMAEA

DGTCY
Length:455
Mass (Da):48,935
Last modified:March 15, 2017 - v1
Checksum:iD12BBC6C11ADB056
GO

Similar proteinsi

Entry informationi

Entry nameiIGA2_HUMAN
AccessioniPrimary (citable) accession number: P0DOX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2017
Last sequence update: March 15, 2017
Last modified: October 25, 2017
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

This sequence is an example of a full-length immunoglobulin alpha-2 heavy chain.Curated

Keywords - Technical termi

Direct protein sequencing