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Protein

Cytochrome P450 27C1

Gene

cyp27c1

Organism
Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Efficiently catalyzes the conversion of all-trans retinol (also called vitamin A1, the precursor of 11-cis retinal) to 3,4-didehydroretinol (also called vitamin A2, the precursor of 11-cis 3,4-didehydroretinal), also acts on all-trans retinal and all-trans retinoic acid. The replacement of 11-cis retinal chromophore in photopigments with 11-cis 3,4-didehydroretinal enhances sensitivity to long-wavelength light. This may improve vision in fresh water which is often turbid.By similarity

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi483Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 27C1 (EC:1.14.19.-By similarity)
Alternative name(s):
All-trans retinol 3,4-desaturaseBy similarity
Gene namesi
Name:cyp27c1
OrganismiLithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Taxonomic identifieri8400 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaeRanaAquarana

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004389131 – 537Cytochrome P450 27C1Add BLAST537

Expressioni

Tissue specificityi

Expressed in the dorsal third of retinal pigment epithelium, but not in the ventral counterpart (at protein level).1 Publication

Structurei

3D structure databases

SMRiP0DOX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

P0DOX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWQCWLQQA QRMRMMMKAL LRFRATRLDS EMMGGWRRGA QRLAAGVVEG
60 70 80 90 100
QRTLPQEGAA AGPRNLKEMP GPSTFRNLLE FFWRDGFSRI HEIQQNHIRE
110 120 130 140 150
YGRIFKSHFG PQFVVSIADR DMVAQILRAE RDAPQRANME SWQEYRDLRG
160 170 180 190 200
RSTGLISAEG KKWLAMRSVL RQKILRPRDV FIYAGGVNEV VSDLIKRIKT
210 220 230 240 250
LRSREDDGET VTNVNDLYFK YSMEAVATIL YECRLGCLQN EVPKQTLEYI
260 270 280 290 300
EALELMFSMF KTTMYAGAIP KWLRPFIPKP WEEFCRSWDG LFRFSQIHVD
310 320 330 340 350
GRLREIQACL DRGEEVKGGL LTSILISKEL TLEELYANMT EMLLAGVDTT
360 370 380 390 400
SFTLSWATYL LAKNPQAQQM VYDQIVQNLG KDTVPTAEDV PKLPLIRAVL
410 420 430 440 450
KETLRLFPVL PGNGRVTQDD LVLGGYLIPK GTQLALCHYS TSYDQEYFTA
460 470 480 490 500
AEDFQPGRWL RHGHLDRVEN FGSIPFGYGI RSCIGKRVAE LEIHLALIQL
510 520 530
LQNFEIRTSP KTQTVLPKTH GLLCPAGAIN VRFVNRE
Length:537
Mass (Da):61,621
Last modified:February 15, 2017 - v1
Checksum:iD8712BA2CD2CCF12
GO

Similar proteinsi

Entry informationi

Entry nameiC27C1_LITCT
AccessioniPrimary (citable) accession number: P0DOX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2017
Last sequence update: February 15, 2017
Last modified: August 30, 2017
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families