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Protein

AimR transcriptional regulator

Gene

aimR

Organism
Bacillus phage phi3T (Bacteriophage phi-3T)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator which is part of the latency-replication switch system that decides at the onset of infection whether to replicate and lyse the host or to lysogenize (latency) and keep the host viable. Activates the transcription of the aimX locus. Transcriptional activation of aimX seems to lead to the productive viral replication (lytic cycle), aimX possibly acting as a regulatory non-coding RNA.1 Publication

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processLatency-replication decision, Transcription, Transcription regulation, Viral latency

Names & Taxonomyi

Protein namesi
Recommended name:
AimR transcriptional regulator1 Publication
Alternative name(s):
Arbitrium communication peptide receptor1 Publication
Gene namesi
Name:aimR
Ordered Locus Names:phi3T_89
OrganismiBacillus phage phi3T (Bacteriophage phi-3T)
Taxonomic identifieri10736 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeLambdavirusunclassified Lambda-like viruses
Virus hostiBacillus subtilis [TaxID: 1423]
Proteomesi
  • UP000188400 Componenti: Bacillus phage phi3T

Pathology & Biotechi

Disruption phenotypei

Knockdown results in decreased AimX transcription and increased lysogeny.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004392561 – 378AimR transcriptional regulatorAdd BLAST378

Interactioni

Subunit structurei

Homodimer. Interacts with the viral arbitrium peptide, this interaction changes the oligomeric state of AimR from an active dimer to an inactive monomer leading to lysogeny.1 Publication

Structurei

3D structure databases

SMRiP0DOE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiView protein in InterPro
IPR011990. TPR-like_helical_dom.
SUPFAMiSSF48452. SSF48452. 1 hit.

Sequencei

Sequence statusi: Complete.

P0DOE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKNECEKDN QLAARLAKLA GYEKVNGFYK FVNTPEKEME NLGGLLKIVK
60 70 80 90 100
NLFPDSEEQL LSEYFLELDP NKKCARQSVE YSDINQWDTL TDKIIINLCN
110 120 130 140 150
SKNSTSQEWG KVYSLHRKLN KNEISLNDAI RESGKCKIKS AEMLFFSNAM
160 170 180 190 200
LMYAYLNIGE FGLMKSTSKL LEFDDLPEGF IKESFKSRVS MLEANISLNE
210 220 230 240 250
NSLLEARQHS NRAIENSNVN RICFFAYLTI GNTLIFEDYD EAKKAYIKGQ
260 270 280 290 300
KYAKNPVHQE MLDGALCFLS NIWKKENQWV NYNSDNIKYL QLRAFYYINQ
310 320 330 340 350
GNIEEATEIL DELSSRDQDE NELGFYYYYK GLISQDKTDY YKSIRYFKKS
360 370
DDKYFIQLPL LQLERMGADL ELLNLISI
Length:378
Mass (Da):44,107
Last modified:March 15, 2017 - v1
Checksum:i053B37DF45FAC825
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KY030782 Genomic DNA. Translation: APD21232.1.

Similar proteinsi

Entry informationi

Entry nameiAIMR_BPPHT
AccessioniPrimary (citable) accession number: P0DOE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2017
Last sequence update: March 15, 2017
Last modified: August 30, 2017
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries