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Protein

Protein AimP

Gene

aimP

Organism
Bacillus phage phi3T (Bacteriophage phi-3T)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Protein AimP: Part of the latency-replication switch system which decides at the onset of infection whether to replicate and lyse the host or to lysogenize (latency) and keep the host viable.1 Publication
Arbitrium peptide: Peptide which is released by the infected host bacteria and acts as a communication agent that affects the latency versus replication (lysogeny-lysis) decision for any new infecting virus from the same specie. High concentration of arbitrium peptide results in increased lysogeny in the upcoming viruses. The arbitrium peptide is secreted by infected bacteria and, after several cycles of infection, accumulates in the extracellular medium. When a virus from the same specie subsequently infects an uninfected bacterium which has internalized the peptide via its OPP transporter, the peptide will binds to the viral AimR transcriptional regulator and prevents AimR transcriptional activation of the aimX locus. Inhibition of aimX transcription promotes lysogeny.1 Publication

GO - Biological processi

  • latency-replication decision Source: UniProtKB
  • viral latency Source: UniProtKB-KW

Keywordsi

Biological processLatency-replication decision, Viral latency

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AimP1 Publication
Cleaved into the following chain:
Arbitrium peptide1 Publication
Gene namesi
Name:aimP
Ordered Locus Names:phi3T_90
OrganismiBacillus phage phi3T (Bacteriophage phi-3T)
Taxonomic identifieri10736 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeLambdavirusunclassified Lambda-like viruses
Virus hostiBacillus subtilis [TaxID: 1423]
Proteomesi
  • UP000188400 Componenti: Bacillus phage phi3T

Subcellular locationi

Peptide Arbitrium peptide :

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000043925231 – 43Protein AimPSequence analysisAdd BLAST13
PeptideiPRO_000043925338 – 43Arbitrium peptide1 Publication6

Post-translational modificationi

Protein AimP: Cleaved by host extracellular proteases, thereby releasing the mature arbitrium peptide.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei37 – 38Cleavage; by host1 Publication2

Interactioni

Subunit structurei

Arbitrium peptide: Interacts with the viral AimR transcriptional regulator; this interaction changes the oligomeric state of AimR from an active dimer to an inactive monomer leading to lysogeny.1 Publication

Family & Domainsi

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DOE2-1 [UniParc]FASTAAdd to basket

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        10         20         30         40 
MKKVFFGLVI LTALAISFVA GQQSVSTASA SDEVTVASAI RGA
Length:43
Mass (Da):4,343
Last modified:March 15, 2017 - v1
Checksum:i0EBF3F276E6767F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KY030782 Genomic DNA. Translation: APD21233.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiAIMP_BPPHT
AccessioniPrimary (citable) accession number: P0DOE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2017
Last sequence update: March 15, 2017
Last modified: July 5, 2017
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome