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Protein

Choriogonadotropin subunit beta 3

Gene

CGB3

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.Curated

Miscellaneous

Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific CGB proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8).Curated

GO - Molecular functioni

  • hormone activity Source: ProtInc

GO - Biological processi

  • apoptotic process Source: ProtInc
  • cell-cell signaling Source: ProtInc
  • female gamete generation Source: ProtInc
  • peptide hormone processing Source: Reactome
  • regulation of transcription from RNA polymerase II promoter Source: Reactome
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-209822. Glycoprotein hormones.
R-HSA-8866910. TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Choriogonadotropin subunit beta 3
Alternative name(s):
Choriogonadotropin subunit beta
Short name:
CG-beta
Chorionic gonadotropin chain beta
Gene namesi
Name:CGB3
Synonyms:CGB
AND
Name:CGB5
AND
Name:CGB8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:1886. CGB3.
HGNC:16452. CGB5.
HGNC:16453. CGB8.
MIMi118860. gene.
608825. gene.
608827. gene.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Available under the names Novarel (Ferring) and Profasi (Serono). Used as adjunctive therapy in the treatment of obesity. There is no substantial evidence that it increases weight loss beyond that resulting from caloric restriction, that it causes a more attractive or 'normal' distribution of fat, or that it decreases the hunger and discomfort associated with calorie-restricted diets.

Organism-specific databases

DisGeNETi1082.
93659.
94115.
OpenTargetsiENSG00000189052.
ENSG00000213030.

Polymorphism and mutation databases

BioMutaiCGB.
DMDMi116184.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 202 PublicationsAdd BLAST20
ChainiPRO_000001167621 – 165Choriogonadotropin subunit beta 3Add BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 772 Publications
GlycosylationiCAR_00004233N-linked (GlcNAc...) asparagineCombined sources1
Disulfide bondi43 ↔ 922 Publications
Disulfide bondi46 ↔ 1302 Publications
GlycosylationiCAR_00004350N-linked (GlcNAc...) asparagineCombined sources1
Disulfide bondi54 ↔ 1082 Publications
Disulfide bondi58 ↔ 1102 Publications
Disulfide bondi113 ↔ 1202 Publications
Glycosylationi141O-linked (GalNAc...) serine1 Publication1
Glycosylationi147O-linked (GalNAc...) serine1 Publication1
Glycosylationi152O-linked (GalNAc...) serine1 Publication1
Glycosylationi158O-linked (GalNAc...) serine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP0DN86.
PeptideAtlasiP0DN86.

PTM databases

iPTMnetiP0DN86.
PhosphoSitePlusiP0DN86.
UniCarbKBiP01233.

Expressioni

Tissue specificityi

High expression in the placenta throughout pregnancy.1 Publication

Developmental stagei

Expressed continuously during the whole pregnancy with a peak during the first trimester.1 Publication

Gene expression databases

CleanExiHS_CGB.
HS_CGB5.
HS_CGB7.
ExpressionAtlasiP0DN86. baseline and differential.
GenevisibleiP01233. HS.

Organism-specific databases

HPAiHPA038925.
HPA038934.

Interactioni

Subunit structurei

Heterodimer of a common alpha chain identical in LH, FSH, TSH and HCG and a unique beta chain distinct in each of the hormones.Curated1 Publication

GO - Molecular functioni

  • hormone activity Source: ProtInc

Protein-protein interaction databases

IntActiP0DN86. 2 interactors.
MINTiMINT-1510897.

Structurei

Secondary structure

1165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 38Combined sources14
Beta strandi47 – 60Combined sources14
Beta strandi75 – 88Combined sources14
Beta strandi99 – 112Combined sources14
Turni115 – 117Combined sources3
Beta strandi118 – 121Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HCNX-ray2.60B21-165[»]
1HRPX-ray3.00B21-165[»]
1QFWX-ray3.50B21-165[»]
1XULmodel-B21-165[»]
DisProtiDP00013.
ProteinModelPortaliP0DN86.
SMRiP0DN86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000010115.
HOVERGENiHBG006698.
KOiK10045.
OMAiTVNATIC.
PhylomeDBiP0DN86.
TreeFamiTF332940.

Family and domain databases

CDDicd00069. GHB_like. 1 hit.
Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiView protein in Pfam
PF00007. Cys_knot. 1 hit.
SMARTiView protein in SMART
SM00068. GHB. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P0DN86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEMFQGLLLL LLLSMGGTWA SKEPLRPRCR PINATLAVEK EGCPVCITVN
60 70 80 90 100
TTICAGYCPT MTRVLQGVLP ALPQVVCNYR DVRFESIRLP GCPRGVNPVV
110 120 130 140 150
SYAVALSCQC ALCRRSTTDC GGPKDHPLTC DDPRFQDSSS SKAPPPSLPS
160
PSRLPGPSDT PILPQ
Length:165
Mass (Da):17,739
Last modified:May 11, 2016 - v1
Checksum:i5598FB9E51A05748
GO
Isoform 2 (identifier: P0DN86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MEMF → MGRPGLGAAVSDPGEAVSLS

Show »
Length:181
Mass (Da):19,053
Checksum:i853B736271867359
GO

Sequence cautioni

The sequence CAA25068 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA25069 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123P → T in AAL69709 (PubMed:11861891).Curated1
Isoform 2 (identifier: P0DN86-2)
Sequence conflicti7G → R in CAA25069 (PubMed:6690982).Curated1
Sequence conflicti9A → V in CAA25069 (PubMed:6690982).Curated1
Sequence conflicti12D → G in CAA25069 (PubMed:6690982).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0145854F → L1 PublicationCorresponds to variants dbSNP:rs767100833 and dbSNP:rs371475564EnsemblEnsembl.1
Natural variantiVAR_01523118T → A1 PublicationCorresponds to variant dbSNP:rs201240617Ensembl.1
Natural variantiVAR_01458622K → R1 PublicationCorresponds to variants dbSNP:rs201575305 and dbSNP:rs199720009EnsemblEnsembl.1
Natural variantiVAR_01523224P → M Requires 2 nucleotide substitutions. 2 Publications1
Natural variantiVAR_01523328R → W1 Publication1
Natural variantiVAR_01523430R → H1 PublicationCorresponds to variant dbSNP:rs201373221Ensembl.1
Natural variantiVAR_01458735T → I1 PublicationCorresponds to variants dbSNP:rs201780746 and dbSNP:rs199824672EnsemblEnsembl.1
Natural variantiVAR_003188137D → A4 PublicationsCorresponds to variants dbSNP:rs200199557 and dbSNP:rs199614255EnsemblEnsembl.1
Natural variantiVAR_015235147S → C1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0383961 – 4MEMF → MGRPGLGAAVSDPGEAVSLS in isoform 2. Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00117 mRNA. Translation: AAA96690.1.
X00265 Genomic DNA. Translation: CAA25068.1. Different initiation.
X00266 Genomic DNA. Translation: CAA25069.1. Different initiation.
K03189, K03187, K03188 Genomic DNA. Translation: AAA53288.1.
K03183, K00092, K03182 Genomic DNA. Translation: AAA53287.1.
BT006890 mRNA. Translation: AAP35536.1.
AK291552 mRNA. Translation: BAF84241.1.
AC008687 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52434.1.
CH471177 Genomic DNA. Translation: EAW52437.1.
CH471177 Genomic DNA. Translation: EAW52438.1.
BC006290 mRNA. Translation: AAH06290.1.
BC022796 mRNA. Translation: AAH22796.1.
BC030994 mRNA. Translation: AAH30994.1.
BC041054 mRNA. Translation: AAH41054.1.
BC051378 mRNA. Translation: AAH51378.1.
BC069526 mRNA. Translation: AAH69526.1.
BC103969 mRNA. Translation: AAI03970.1.
BC103970 mRNA. Translation: AAI03971.1.
BC103971 mRNA. Translation: AAI03972.1.
BC106059 mRNA. Translation: AAI06060.1.
BC106723 mRNA. Translation: AAI06724.1.
BC106724 mRNA. Translation: AAI06725.1.
BC128603 mRNA. Translation: AAI28604.1.
M13503 Genomic DNA. Translation: AAA52009.1.
M13504 Genomic DNA. Translation: AAA52005.1.
M13505 Genomic DNA. Translation: AAA52008.1.
AF397576 Genomic DNA. Translation: AAL69704.1.
AF397577 Genomic DNA. Translation: AAL69705.1.
AF397578 Genomic DNA. Translation: AAL69706.1.
AF397579 Genomic DNA. Translation: AAL69707.1.
AF397580 Genomic DNA. Translation: AAL69708.1.
AF397581 Genomic DNA. Translation: AAL69709.1.
CCDSiCCDS12749.1. [P0DN86-1]
PIRiA93230. KTHUB.
I37231.
RefSeqiNP_000728.1. NM_000737.3. [P0DN86-1]
NP_149032.1. NM_033043.1. [P0DN86-1]
NP_149439.1. NM_033183.2. [P0DN86-1]
UniGeneiHs.172944.
Hs.446683.
Hs.659014.
Hs.681647.
Hs.743279.
Hs.745468.

Genome annotation databases

EnsembliENST00000301408; ENSP00000301408; ENSG00000189052. [P0DN86-1]
ENST00000357383; ENSP00000349954; ENSG00000104827. [P0DN86-1]
ENST00000448456; ENSP00000403649; ENSG00000213030. [P0DN86-1]
GeneIDi1082.
93659.
94115.
KEGGihsa:1082.
hsa:93659.
hsa:94115.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCGB3_HUMAN
AccessioniPrimary (citable) accession number: P0DN86
Secondary accession number(s): A1A5E0
, B9ZVP5, P01233, Q13991, Q14000, Q3KPI3, Q3SY41, Q8WTT5, Q8WXL1, Q8WXL2, Q8WXL3, Q8WXL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 11, 2016
Last sequence update: May 11, 2016
Last modified: October 25, 2017
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families