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Protein

Transmembrane domain-containing protein TMIGD3

Gene

TMIGD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane domain-containing protein TMIGD3Curated
Gene namesi
Name:TMIGD3Imported
ORF Names:UNQ1931/PRO4406
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:51375. TMIGD3.

Subcellular locationi

  1. Membrane Sequence Analysis; Multi-pass membrane protein Sequence Analysis

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei55 – 7521HelicalSequence AnalysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24589.

Polymorphism and mutation databases

BioMutaiCBR3.
DMDMi380876892.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Transmembrane domain-containing protein TMIGD3PRO_0000416044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074524.
HOVERGENiHBG058258.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013783. Ig-like_fold.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P0DMS9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGSPAGPIE QKEARWESSW EEQPDWTLGC LSPESQFRIP GLPGCILSFQ
60 70 80 90 100
LKVCFLPVMW LFILLSLALI SDAMVMDEKV KRSFVLDTAS AICNYNAHYK
110 120 130 140 150
NHPKYWCRGY FRDYCNIIAF SPNSTNHVAL RDTGNQLIVT MSCLTKEDTG
160 170 180 190 200
WYWCGIQRDF ARDDMDFTEL IVTDDKGTLA NDFWSGKDLS GNKTRSCKAP
210 220 230 240 250
KVVRKADRSR TSILIICILI TGLGIISVIS HLTKRRRSQR NRRVGNTLKP
260
FSRVLTPKEM APTEQM
Length:266
Mass (Da):30,327
Last modified:April 1, 2015 - v1
Checksum:i8D6506430DD5C208
GO
Isoform 2 (identifier: P0DMS9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MEGSPAGPIE...TLGCLSPESQ → MPNNSTALSL...RYLRVKLTVR

Show »
Length:347
Mass (Da):38,976
Checksum:i7F4974135F4F04A6
GO

Sequence cautioni

The sequence AAH41707.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH64411.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW56500.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3636MEGSP…SPESQ → MPNNSTALSLANVTYITMEI FIGLCAIVGNVLVICVVKLN PSLQTTTFYFIVSLALADIA VGVLVMPLAIVVSLGITIHF YSCLFMTCLLLIFTHASIMS LLAIAVDRYLRVKLTVR in isoform 2. VSP_057521Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358644 mRNA. Translation: AAQ89007.1.
AL390195, AL391063 Genomic DNA. Translation: CAI15626.1.
AL391063, AL390195 Genomic DNA. Translation: CAI22964.1.
CH471122 Genomic DNA. Translation: EAW56500.1. Sequence problems.
BC041707 mRNA. Translation: AAH41707.1. Different initiation.
BC064411 mRNA. Translation: AAH64411.1. Different initiation.
RefSeqiNP_001075445.1. NM_001081976.2.
NP_001289609.1. NM_001302680.1.
NP_065734.5. NM_020683.6.
UniGeneiHs.281342.

Genome annotation databases

GeneIDi57413.

Polymorphism and mutation databases

BioMutaiCBR3.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358644 mRNA. Translation: AAQ89007.1.
AL390195, AL391063 Genomic DNA. Translation: CAI15626.1.
AL391063, AL390195 Genomic DNA. Translation: CAI22964.1.
CH471122 Genomic DNA. Translation: EAW56500.1. Sequence problems.
BC041707 mRNA. Translation: AAH41707.1. Different initiation.
BC064411 mRNA. Translation: AAH64411.1. Different initiation.
RefSeqiNP_001075445.1. NM_001081976.2.
NP_001289609.1. NM_001302680.1.
NP_065734.5. NM_020683.6.
UniGeneiHs.281342.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiCBR3.
DMDMi380876892.

Protocols and materials databases

DNASUi140.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi57413.

Organism-specific databases

CTDi57413.
GeneCardsiGC01M112025.
HGNCiHGNC:51375. TMIGD3.
PharmGKBiPA24589.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00550000074524.
HOVERGENiHBG058258.

Miscellaneous databases

ChiTaRSiADORA3. human.
GenomeRNAii140.
NextBioi553.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013783. Ig-like_fold.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-266 (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiTMIG3_HUMAN
AccessioniPrimary (citable) accession number: P0DMS9
Secondary accession number(s): A2A3P4
, P33765, Q5QNY7, Q6P2N6, Q6UWU0, Q9BYZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 2015
Last sequence update: April 1, 2015
Last modified: April 29, 2015
This is version 2 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.