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Protein

Transmembrane domain-containing protein TMIGD3

Gene

TMIGD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • activation of adenylate cyclase activity Source: ProtInc
  • inflammatory response Source: ProtInc
  • regulation of heart contraction Source: ProtInc
  • response to wounding Source: ProtInc
  • signal transduction Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane domain-containing protein TMIGD3Curated
Gene namesi
Name:TMIGD3Imported
ORF Names:UNQ1931/PRO4406
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000121933.17.
HGNCiHGNC:51375. TMIGD3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000121933.
PharmGKBiPA24589.

Chemistry databases

ChEMBLiCHEMBL3712907.

Polymorphism and mutation databases

BioMutaiCBR3.
DMDMi380876892.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004160441 – 266Transmembrane domain-containing protein TMIGD3Add BLAST266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP0DMS9.
PeptideAtlasiP0DMS9.
PRIDEiP0DMS9.

Expressioni

Gene expression databases

BgeeiENSG00000121933.
ExpressionAtlasiP0DMS9. baseline and differential.
GenevisibleiP0DMS9. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000358730.

Structurei

3D structure databases

ProteinModelPortaliP0DMS9.
SMRiP0DMS9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KDMS. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00860000133936.
HOVERGENiHBG058258.
OMAiSAICNYD.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P0DMS9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGSPAGPIE QKEARWESSW EEQPDWTLGC LSPESQFRIP GLPGCILSFQ
60 70 80 90 100
LKVCFLPVMW LFILLSLALI SDAMVMDEKV KRSFVLDTAS AICNYNAHYK
110 120 130 140 150
NHPKYWCRGY FRDYCNIIAF SPNSTNHVAL RDTGNQLIVT MSCLTKEDTG
160 170 180 190 200
WYWCGIQRDF ARDDMDFTEL IVTDDKGTLA NDFWSGKDLS GNKTRSCKAP
210 220 230 240 250
KVVRKADRSR TSILIICILI TGLGIISVIS HLTKRRRSQR NRRVGNTLKP
260
FSRVLTPKEM APTEQM
Length:266
Mass (Da):30,327
Last modified:April 1, 2015 - v1
Checksum:i8D6506430DD5C208
GO
Isoform 2 (identifier: P0DMS9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MEGSPAGPIE...TLGCLSPESQ → MPNNSTALSL...RYLRVKLTVR

Note: Splice isoform that shares its 5' terminal exon with that of the overlapping ADORA3 gene, resulting in a fusion protein.
Show »
Length:347
Mass (Da):38,976
Checksum:i7F4974135F4F04A6
GO

Sequence cautioni

The sequence AAH41707 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH64411 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW56500 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0575211 – 36MEGSP…SPESQ → MPNNSTALSLANVTYITMEI FIGLCAIVGNVLVICVVKLN PSLQTTTFYFIVSLALADIA VGVLVMPLAIVVSLGITIHF YSCLFMTCLLLIFTHASIMS LLAIAVDRYLRVKLTVR in isoform 2. Add BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358644 mRNA. Translation: AAQ89007.1.
AL390195, AL391063 Genomic DNA. Translation: CAI15626.1.
AL391063, AL390195 Genomic DNA. Translation: CAI22964.1.
CH471122 Genomic DNA. Translation: EAW56500.1. Sequence problems.
BC041707 mRNA. Translation: AAH41707.1. Different initiation.
BC064411 mRNA. Translation: AAH64411.1. Different initiation.
CCDSiCCDS41369.1. [P0DMS9-1]
CCDS838.1. [P0DMS9-2]
RefSeqiNP_001075445.1. NM_001081976.2. [P0DMS9-1]
NP_001289609.1. NM_001302680.1.
NP_065734.5. NM_020683.6. [P0DMS9-2]
UniGeneiHs.281342.

Genome annotation databases

EnsembliENST00000369716; ENSP00000358730; ENSG00000121933. [P0DMS9-2]
ENST00000369717; ENSP00000358731; ENSG00000121933. [P0DMS9-1]
GeneIDi57413.
KEGGihsa:57413.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTMIG3_HUMAN
AccessioniPrimary (citable) accession number: P0DMS9
Secondary accession number(s): A2A3P4
, P33765, Q5QNY7, Q6P2N6, Q6UWU0, Q9BYZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 2015
Last sequence update: April 1, 2015
Last modified: September 27, 2017
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM