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Protein

Adenosine receptor A3

Gene

ADORA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-417973. Adenosine P1 receptors.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A3
Gene namesi
Name:ADORA3Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:268. ADORA3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14ExtracellularBy similarityAdd BLAST14
Transmembranei15 – 37Helical; Name=1By similarityAdd BLAST23
Topological domaini38 – 48CytoplasmicBy similarityAdd BLAST11
Transmembranei49 – 72Helical; Name=2By similarityAdd BLAST24
Topological domaini73 – 84ExtracellularBy similarityAdd BLAST12
Transmembranei85 – 106Helical; Name=3By similarityAdd BLAST22
Topological domaini107 – 126CytoplasmicBy similarityAdd BLAST20
Transmembranei127 – 148Helical; Name=4By similarityAdd BLAST22
Topological domaini149 – 177ExtracellularBy similarityAdd BLAST29
Transmembranei178 – 198Helical; Name=5By similarityAdd BLAST21
Topological domaini199 – 231CytoplasmicBy similarityAdd BLAST33
Transmembranei232 – 255Helical; Name=6By similarityAdd BLAST24
Topological domaini256 – 261ExtracellularBy similarity6
Transmembranei262 – 284Helical; Name=7By similarityAdd BLAST23
Topological domaini285 – 318CytoplasmicBy similarityAdd BLAST34

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000282608.

Chemistry databases

ChEMBLiCHEMBL256.
DrugBankiDB00640. Adenosine.
DB01223. Aminophylline.
DB00824. Enprofylline.
GuidetoPHARMACOLOGYi21.

Polymorphism and mutation databases

DMDMi1351831.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690101 – 318Adenosine receptor A3Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi12N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi83 ↔ 166PROSITE-ProRule annotation
Lipidationi303S-palmitoyl cysteineSequence analysis1

Post-translational modificationi

Phosphorylation on Ser-317 may be crucial for rapid desensitization.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

PTM databases

PhosphoSitePlusiP0DMS8.

Expressioni

Gene expression databases

CleanExiHS_ADORA3.
ExpressionAtlasiP0DMS8. baseline.
GenevisibleiP0DMS8. HS.

Organism-specific databases

HPAiHPA028509.
HPA028566.
HPA028568.

Interactioni

Chemistry databases

BindingDBiP0DMS8.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OEAmodel-A1-298[»]
1R7Nmodel-A1-318[»]
ProteinModelPortaliP0DMS8.
SMRiP0DMS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074524.
HOVERGENiHBG106962.
KOiK04268.
OMAiKRVTTHR.
PhylomeDBiP0DMS8.
TreeFamiTF334441.

Family and domain databases

InterProiIPR000466. Adeno_A3_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00555. ADENOSINEA3R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P0DMS8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPNNSTALSL ANVTYITMEI FIGLCAIVGN VLVICVVKLN PSLQTTTFYF
60 70 80 90 100
IVSLALADIA VGVLVMPLAI VVSLGITIHF YSCLFMTCLL LIFTHASIMS
110 120 130 140 150
LLAIAVDRYL RVKLTVRYKR VTTHRRIWLA LGLCWLVSFL VGLTPMFGWN
160 170 180 190 200
MKLTSEYHRN VTFLSCQFVS VMRMDYMVYF SFLTWIFIPL VVMCAIYLDI
210 220 230 240 250
FYIIRNKLSL NLSNSKETGA FYGREFKTAK SLFLVLFLFA LSWLPLSIIN
260 270 280 290 300
CIIYFNGEVP QLVLYMGILL SHANSMMNPI VYAYKIKKFK ETYLLILKAC
310
VVCHPSDSLD TSIEKNSE
Length:318
Mass (Da):36,185
Last modified:April 1, 2015 - v1
Checksum:i690E67986130FC28
GO
Isoform 2 (identifier: P0DMS9-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0DMS9.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Splice isoform that shares its 5' terminal exon with that of the overlapping TMIGD3 gene, resulting in a fusion protein.
Length:347
Mass (Da):38,976
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7A → T in AAA16365 (PubMed:8399349).Curated1
Sequence conflicti175D → V in AAG35155 (PubMed:11214319).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035755105A → T in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs746154553dbSNPEnsembl.1
Natural variantiVAR_049366248I → L.1 PublicationCorresponds to variant rs35511654dbSNPEnsembl.1
Natural variantiVAR_049367266M → K.Corresponds to variant rs2800889dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20463 mRNA. Translation: AAA16365.1.
L22607 mRNA. Translation: AAA35949.1.
X76981 mRNA. Translation: CAA54288.1.
L77730, L77729 Genomic DNA. Translation: AAB02790.1.
AY136749 mRNA. Translation: AAN01275.1.
AL390195 Genomic DNA. Translation: CAC36045.1.
AL390195 Genomic DNA. Translation: CAM21993.1.
BC029831 mRNA. Translation: AAH29831.1.
AY011231 Genomic DNA. Translation: AAG35155.1.
CCDSiCCDS839.1. [P0DMS8-1]
PIRiS38511.
RefSeqiNP_000668.1. NM_000677.3. [P0DMS8-1]
UniGeneiHs.281342.

Genome annotation databases

EnsembliENST00000241356; ENSP00000241356; ENSG00000282608. [P0DMS8-1]
GeneIDi140.
KEGGihsa:140.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20463 mRNA. Translation: AAA16365.1.
L22607 mRNA. Translation: AAA35949.1.
X76981 mRNA. Translation: CAA54288.1.
L77730, L77729 Genomic DNA. Translation: AAB02790.1.
AY136749 mRNA. Translation: AAN01275.1.
AL390195 Genomic DNA. Translation: CAC36045.1.
AL390195 Genomic DNA. Translation: CAM21993.1.
BC029831 mRNA. Translation: AAH29831.1.
AY011231 Genomic DNA. Translation: AAG35155.1.
CCDSiCCDS839.1. [P0DMS8-1]
PIRiS38511.
RefSeqiNP_000668.1. NM_000677.3. [P0DMS8-1]
UniGeneiHs.281342.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OEAmodel-A1-298[»]
1R7Nmodel-A1-318[»]
ProteinModelPortaliP0DMS8.
SMRiP0DMS8.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiP0DMS8.
ChEMBLiCHEMBL256.
DrugBankiDB00640. Adenosine.
DB01223. Aminophylline.
DB00824. Enprofylline.
GuidetoPHARMACOLOGYi21.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP0DMS8.

Polymorphism and mutation databases

DMDMi1351831.

Protocols and materials databases

DNASUi140.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000241356; ENSP00000241356; ENSG00000282608. [P0DMS8-1]
GeneIDi140.
KEGGihsa:140.

Organism-specific databases

CTDi140.
GeneCardsiADORA3.
HGNCiHGNC:268. ADORA3.
HPAiHPA028509.
HPA028566.
HPA028568.
MIMi600445. gene.
neXtProtiNX_P0DMS8.
OpenTargetsiENSG00000282608.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00550000074524.
HOVERGENiHBG106962.
KOiK04268.
OMAiKRVTTHR.
PhylomeDBiP0DMS8.
TreeFamiTF334441.

Enzyme and pathway databases

ReactomeiR-HSA-417973. Adenosine P1 receptors.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSiADORA3. human.
GeneWikiiAdenosine_A3_receptor.
GenomeRNAii140.
PROiP0DMS8.
SOURCEiSearch...

Gene expression databases

CleanExiHS_ADORA3.
ExpressionAtlasiP0DMS8. baseline.
GenevisibleiP0DMS8. HS.

Family and domain databases

InterProiIPR000466. Adeno_A3_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00555. ADENOSINEA3R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAA3R_HUMAN
AccessioniPrimary (citable) accession number: P0DMS8
Secondary accession number(s): A2A3P4
, P33765, Q6UWU0, Q9BYZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 2015
Last sequence update: April 1, 2015
Last modified: November 30, 2016
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.