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Protein

O-antigen biosynthesis glycosyltransferase WbnH

Gene

wbnH

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the assembly of the O-repeating unit during O-antigen biosynthesis.2 Publications

Catalytic activityi

UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-alpha-D-galactosaminyl-diphospho-ditrans,octacis-undecaprenol = UDP + alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol.2 Publications

Pathwayi: LPS O-antigen biosynthesis

This protein is involved in the pathway LPS O-antigen biosynthesis, which is part of Bacterial outer membrane biogenesis.2 Publications
View all proteins of this organism that are known to be involved in the pathway LPS O-antigen biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00281.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
O-antigen biosynthesis glycosyltransferase WbnHCurated (EC:2.4.1.3062 Publications)
Alternative name(s):
UDP-GalNAc:alpha-D-GalNAc-diphosphoundecaprenol alpha-1,3-N-acetylgalactosaminyltransferaseCurated
Gene namesi
Name:wbnH1 Publication
Synonyms:wbwH1 Publication, wcmA1 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004306471 – 338O-antigen biosynthesis glycosyltransferase WbnHAdd BLAST338

Structurei

Secondary structure

1338
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Beta strandi12 – 14Combined sources3
Helixi15 – 27Combined sources13
Turni28 – 30Combined sources3
Beta strandi31 – 39Combined sources9
Helixi42 – 45Combined sources4
Beta strandi50 – 54Combined sources5
Helixi56 – 59Combined sources4
Helixi64 – 76Combined sources13
Beta strandi81 – 86Combined sources6
Helixi87 – 95Combined sources9
Helixi96 – 98Combined sources3
Beta strandi102 – 107Combined sources6
Helixi109 – 111Combined sources3
Helixi122 – 132Combined sources11
Beta strandi136 – 142Combined sources7
Helixi143 – 151Combined sources9
Helixi157 – 159Combined sources3
Beta strandi160 – 162Combined sources3
Beta strandi181 – 186Combined sources6
Helixi194 – 202Combined sources9
Beta strandi207 – 212Combined sources6
Turni224 – 227Combined sources4
Beta strandi231 – 235Combined sources5
Helixi243 – 245Combined sources3
Beta strandi247 – 251Combined sources5
Helixi260 – 267Combined sources8
Beta strandi272 – 277Combined sources6
Helixi280 – 283Combined sources4
Beta strandi285 – 291Combined sources7
Helixi295 – 307Combined sources13
Helixi309 – 319Combined sources11
Turni320 – 323Combined sources4
Helixi325 – 327Combined sources3
Helixi329 – 337Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XYWX-ray2.20A1-338[»]
ProteinModelPortaliP0DMP6.
SMRiP0DMP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0DMP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNVGFIVTK SEIGGAQTWV NEISNLIKEE CNIFLITSEE GWLTHKDVFA
60 70 80 90 100
GVFVIPGIKK YFDFLTLFKL RKILKENNIS TLIASSANAG VYARLVRLLV
110 120 130 140 150
DFKCIYVSHG WSCLYNGGRL KSIFCIVEKY LSLLTDVIWC VSKSDEKKAI
160 170 180 190 200
ENIGIKEPKI ITVSNSVPQM PRCNNKQLQY KVLFVGRLTH PKRPELLANV
210 220 230 240 250
ISKKPQYSLH IVGGGERLES LKKQFSECEN IHFLGEVNNF YNYHEYDLFS
260 270 280 290 300
LISDSEGLPM SGLEAHTAAI PLLLSDVGGC FELIEGNGLL VENTEDDIGY
310 320 330
KLDKIFDDYE NYREQAIRAS GKFVIENYAS AYKSIILG
Length:338
Mass (Da):38,148
Last modified:October 29, 2014 - v1
Checksum:iC3A813A3EE248251
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY220982 Genomic DNA. Translation: AAO37709.1.
AY667408 Genomic DNA. Translation: AAV80749.1.
AY670704 Genomic DNA. Translation: AAV85953.1.
RefSeqiWP_000799972.1. NZ_MACN01000004.1.

Genome annotation databases

KEGGiag:AAV80749.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY220982 Genomic DNA. Translation: AAO37709.1.
AY667408 Genomic DNA. Translation: AAV80749.1.
AY670704 Genomic DNA. Translation: AAV85953.1.
RefSeqiWP_000799972.1. NZ_MACN01000004.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XYWX-ray2.20A1-338[»]
ProteinModelPortaliP0DMP6.
SMRiP0DMP6.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:AAV80749.

Enzyme and pathway databases

UniPathwayiUPA00281.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWBNH_ECOLX
AccessioniPrimary (citable) accession number: P0DMP6
Secondary accession number(s): Q5J7D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 29, 2014
Last sequence update: October 29, 2014
Last modified: November 2, 2016
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

O86:H2 and O86:B7 subtypes share the same O unit, but the O units are polymerized from different terminal sugars in different glycosidic linkages.1 Publication

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.