Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

O-antigen biosynthesis glycosyltransferase WbnH

Gene

wbnH

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the assembly of the O-repeating unit during O-antigen biosynthesis.2 Publications

Catalytic activityi

UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-alpha-D-galactosaminyl-diphospho-ditrans,octacis-undecaprenol = UDP + alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol.2 Publications

Pathwayi: LPS O-antigen biosynthesis

This protein is involved in the pathway LPS O-antigen biosynthesis, which is part of Bacterial outer membrane biogenesis.2 Publications
View all proteins of this organism that are known to be involved in the pathway LPS O-antigen biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00281.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
O-antigen biosynthesis glycosyltransferase WbnHCurated (EC:2.4.1.3062 Publications)
Alternative name(s):
UDP-GalNAc:alpha-D-GalNAc-diphosphoundecaprenol alpha-1,3-N-acetylgalactosaminyltransferaseCurated
Gene namesi
Name:wbnH1 Publication
Synonyms:wbwH1 Publication, wcmA1 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338O-antigen biosynthesis glycosyltransferase WbnHPRO_0000430647Add
BLAST

Structurei

Secondary structure

1
338
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 76Combined sources
Beta strandi12 – 143Combined sources
Helixi15 – 2713Combined sources
Turni28 – 303Combined sources
Beta strandi31 – 399Combined sources
Helixi42 – 454Combined sources
Beta strandi50 – 545Combined sources
Helixi56 – 594Combined sources
Helixi64 – 7613Combined sources
Beta strandi81 – 866Combined sources
Helixi87 – 959Combined sources
Helixi96 – 983Combined sources
Beta strandi102 – 1076Combined sources
Helixi109 – 1113Combined sources
Helixi122 – 13211Combined sources
Beta strandi136 – 1427Combined sources
Helixi143 – 1519Combined sources
Helixi157 – 1593Combined sources
Beta strandi160 – 1623Combined sources
Beta strandi181 – 1866Combined sources
Helixi194 – 2029Combined sources
Beta strandi207 – 2126Combined sources
Turni224 – 2274Combined sources
Beta strandi231 – 2355Combined sources
Helixi243 – 2453Combined sources
Beta strandi247 – 2515Combined sources
Helixi260 – 2678Combined sources
Beta strandi272 – 2776Combined sources
Helixi280 – 2834Combined sources
Beta strandi285 – 2917Combined sources
Helixi295 – 30713Combined sources
Helixi309 – 31911Combined sources
Turni320 – 3234Combined sources
Helixi325 – 3273Combined sources
Helixi329 – 3379Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4XYWX-ray2.20A1-338[»]
ProteinModelPortaliP0DMP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0DMP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNVGFIVTK SEIGGAQTWV NEISNLIKEE CNIFLITSEE GWLTHKDVFA
60 70 80 90 100
GVFVIPGIKK YFDFLTLFKL RKILKENNIS TLIASSANAG VYARLVRLLV
110 120 130 140 150
DFKCIYVSHG WSCLYNGGRL KSIFCIVEKY LSLLTDVIWC VSKSDEKKAI
160 170 180 190 200
ENIGIKEPKI ITVSNSVPQM PRCNNKQLQY KVLFVGRLTH PKRPELLANV
210 220 230 240 250
ISKKPQYSLH IVGGGERLES LKKQFSECEN IHFLGEVNNF YNYHEYDLFS
260 270 280 290 300
LISDSEGLPM SGLEAHTAAI PLLLSDVGGC FELIEGNGLL VENTEDDIGY
310 320 330
KLDKIFDDYE NYREQAIRAS GKFVIENYAS AYKSIILG
Length:338
Mass (Da):38,148
Last modified:October 29, 2014 - v1
Checksum:iC3A813A3EE248251
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY220982 Genomic DNA. Translation: AAO37709.1.
AY667408 Genomic DNA. Translation: AAV80749.1.
AY670704 Genomic DNA. Translation: AAV85953.1.
RefSeqiWP_000799972.1. NZ_LVLU01000057.1.

Genome annotation databases

KEGGiag:AAV80749.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY220982 Genomic DNA. Translation: AAO37709.1.
AY667408 Genomic DNA. Translation: AAV80749.1.
AY670704 Genomic DNA. Translation: AAV85953.1.
RefSeqiWP_000799972.1. NZ_LVLU01000057.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4XYWX-ray2.20A1-338[»]
ProteinModelPortaliP0DMP6.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:AAV80749.

Enzyme and pathway databases

UniPathwayiUPA00281.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWBNH_ECOLX
AccessioniPrimary (citable) accession number: P0DMP6
Secondary accession number(s): Q5J7D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 29, 2014
Last sequence update: October 29, 2014
Last modified: July 6, 2016
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

O86:H2 and O86:B7 subtypes share the same O unit, but the O units are polymerized from different terminal sugars in different glycosidic linkages.1 Publication

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.