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Protein

Sulfotransferase 1A4

Gene

SULT1A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.

Catalytic activityi

3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei86Substrate1
Active sitei108Proton acceptorBy similarity1
Binding sitei130PAPS1
Binding sitei138PAPS1
Binding sitei146Substrate1
Binding sitei193PAPS1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi48 – 53PAPS6
Nucleotide bindingi227 – 232PAPS6
Nucleotide bindingi257 – 259PAPS3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCatecholamine metabolism, Lipid metabolism, Steroid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-156584. Cytosolic sulfonation of small molecules.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfotransferase 1A4 (EC:2.8.2.1)
Short name:
ST1A4
Alternative name(s):
Aryl sulfotransferase 1A3/1A4
Sulfotransferase 1A3/1A4
Gene namesi
Name:SULT1A4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000213648.10.
HGNCiHGNC:30004. SULT1A4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi105369243.
445329.
6818.
OpenTargetsiENSG00000261052.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004302041 – 295Sulfotransferase 1A4Add BLAST295

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

EPDiP0DMN0.
PaxDbiP0DMN0.
PRIDEiP0DMN0.

PTM databases

iPTMnetiP0DMN0.
PhosphoSitePlusiP0DMN0.

Expressioni

Tissue specificityi

Liver, colon, kidney, lung, brain, spleen, small intestine, placenta and leukocyte.

Gene expression databases

BgeeiENSG00000213648.
CleanExiHS_SULT1A4.
ExpressionAtlasiP0DMN0. baseline.
GenevisibleiP0DMN0. HS.

Organism-specific databases

HPAiHPA049500.
HPA051051.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi112687. 13 interactors.
138644. 4 interactors.

Structurei

3D structure databases

ProteinModelPortaliP0DMN0.
SMRiP0DMN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 108Substrate binding3

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGiKOG1584. Eukaryota.
ENOG4111H56. LUCA.
GeneTreeiENSGT00760000118932.
KOiK01014.
PhylomeDBiP0DMN0.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
PfamiView protein in Pfam
PF00685. Sulfotransfer_1. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P0DMN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELIQDTSRP PLEYVKGVPL IKYFAEALGP LQSFQARPDD LLINTYPKSG
60 70 80 90 100
TTWVSQILDM IYQGGDLEKC NRAPIYVRVP FLEVNDPGEP SGLETLKDTP
110 120 130 140 150
PPRLIKSHLP LALLPQTLLD QKVKVVYVAR NPKDVAVSYY HFHRMEKAHP
160 170 180 190 200
EPGTWDSFLE KFMAGEVSYG SWYQHVQEWW ELSRTHPVLY LFYEDMKENP
210 220 230 240 250
KREIQKILEF VGRSLPEETM DFMVQHTSFK EMKKNPMTNY TTVPQELMDH
260 270 280 290
SISPFMRKGM AGDWKTTFTV AQNERFDADY AEKMAGCSLS FRSEL
Length:295
Mass (Da):34,196
Last modified:September 3, 2014 - v1
Checksum:iECDDEC03DBE30D46
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_071112101P → H Decreases levels of sulfotransferase activity. 1 Publication1
Natural variantiVAR_071113101P → L Decreases levels of sulfotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs751527244Ensembl.1
Natural variantiVAR_071114144R → C No effect on sulfotransferase activity. 1 Publication1
Natural variantiVAR_071115234K → N Decreases levels of sulfotransferase activity; accelerates proteasome-dependent degradation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC106782 Genomic DNA. No translation available.
AC133555 Genomic DNA. No translation available.
CCDSiCCDS32427.1.
RefSeqiNP_001017390.1. NM_001017390.2.
NP_808220.1. NM_177552.3.
XP_016855108.1. XM_016999619.1.
UniGeneiHs.460558.
Hs.744871.

Genome annotation databases

EnsembliENST00000360423; ENSP00000353600; ENSG00000213648.
GeneIDi105369243.
445329.
6818.
KEGGihsa:105369243.
hsa:445329.
hsa:6818.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiST1A4_HUMAN
AccessioniPrimary (citable) accession number: P0DMN0
Secondary accession number(s): B4DNV0
, O95603, P50224, Q1ET66, Q6ZWJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 3, 2014
Last sequence update: September 3, 2014
Last modified: September 27, 2017
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Found in a segmental duplication on p arm of chromosome 16 giving rise to two identical copies of this gene sharing exons with SLX1A and SLX1B. The ORFs of SULT1A3 and SULT1A4 differ with only a single nucleotide change that does not alter the encoded amino acid. It is not possible to determine whether any individual polymorphism is present within SULT1A3 or SULT1A4 (PubMed:15358107).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families