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Protein

Chorionic somatomammotropin hormone 1

Gene

CSH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi44 – 441Zinc
Metal bindingi200 – 2001Zinc

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-1170546. Prolactin receptor signaling.
R-HSA-982772. Growth hormone receptor signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Chorionic somatomammotropin hormone 1
Short name:
Choriomammotropin
Alternative name(s):
Lactogen
Placental lactogen
Short name:
PL
Gene namesi
Name:CSH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:2440. CSH1.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: AgBase
  • extracellular region Source: Reactome
  • membrane-bounded vesicle Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26262 PublicationsAdd
BLAST
Chaini27 – 217191Chorionic somatomammotropin hormone 1PRO_0000032958Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi79 ↔ 1911 Publication
Disulfide bondi208 ↔ 215In monomeric form1 Publication
Disulfide bondi208 – 208Interchain (with C-215); in dimeric form1 Publication
Disulfide bondi215 – 215Interchain (with C-208); in dimeric form1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP0DML2.

Expressioni

Gene expression databases

CleanExiHS_CSH1.
ExpressionAtlasiP0DML2. baseline and differential.
GenevisibleiP0DML2. HS.

Organism-specific databases

HPAiHPA043715.

Interactioni

Subunit structurei

Can be found in a monomeric as well as dimeric form.1 Publication

Protein-protein interaction databases

BioGridi107829. 8 interactions.
STRINGi9606.ENSP00000316416.

Structurei

Secondary structure

1
217
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi32 – 6130Combined sources
Helixi64 – 663Combined sources
Turni67 – 704Combined sources
Helixi80 – 823Combined sources
Helixi99 – 11012Combined sources
Turni111 – 1144Combined sources
Helixi115 – 1239Combined sources
Beta strandi124 – 1263Combined sources
Turni133 – 1353Combined sources
Helixi136 – 1383Combined sources
Helixi139 – 15416Combined sources
Helixi181 – 21030Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Z7CX-ray2.00A27-217[»]
ProteinModelPortaliP0DML2.
SMRiP0DML2. Positions 29-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFR6. Eukaryota.
ENOG4111HU8. LUCA.
GeneTreeiENSGT00730000111012.
KOiK05438.
OMAiIDKHETQ.
PhylomeDBiP0DML2.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DML2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFDHAM LQAHRAHQLA
60 70 80 90 100
IDTYQEFEET YIPKDQKYSF LHDSQTSFCF SDSIPTPSNM EETQQKSNLE
110 120 130 140 150
LLRISLLLIE SWLEPVRFLR SMFANNLVYD TSDSDDYHLL KDLEEGIQTL
160 170 180 190 200
MGRLEDGSRR TGQILKQTYS KFDTNSHNHD ALLKNYGLLY CFRKDMDKVE
210
TFLRMVQCRS VEGSCGF
Length:217
Mass (Da):25,020
Last modified:July 9, 2014 - v1
Checksum:i235B0DC7A713F431
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti84 – 841I → T AA sequence (PubMed:5286363).Curated
Sequence conflicti95 – 951Missing AA sequence (PubMed:5286363).Curated
Sequence conflicti116 – 1161Missing AA sequence (PubMed:5286363).Curated
Sequence conflicti134 – 1363SDD → BBS AA sequence (PubMed:5286363).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02401 Genomic DNA. Translation: AAA52115.1.
J03071 Genomic DNA. Translation: AAA52551.1.
J00118 mRNA. Translation: AAA98621.1.
BT006926 mRNA. Translation: AAP35572.1.
BC002717 mRNA. Translation: AAH02717.1.
BC005921 mRNA. Translation: AAH05921.1.
BC020756 mRNA. Translation: AAH20756.1.
BC062775 mRNA. Translation: AAH62775.1.
CCDSiCCDS11649.1.
RefSeqiNP_001308.1. NM_001317.5.
UniGeneiHs.654390.

Genome annotation databases

EnsembliENST00000316193; ENSP00000316416; ENSG00000136488.
GeneIDi1442.
KEGGihsa:1442.
UCSCiuc002jcs.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02401 Genomic DNA. Translation: AAA52115.1.
J03071 Genomic DNA. Translation: AAA52551.1.
J00118 mRNA. Translation: AAA98621.1.
BT006926 mRNA. Translation: AAP35572.1.
BC002717 mRNA. Translation: AAH02717.1.
BC005921 mRNA. Translation: AAH05921.1.
BC020756 mRNA. Translation: AAH20756.1.
BC062775 mRNA. Translation: AAH62775.1.
CCDSiCCDS11649.1.
RefSeqiNP_001308.1. NM_001317.5.
UniGeneiHs.654390.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Z7CX-ray2.00A27-217[»]
ProteinModelPortaliP0DML2.
SMRiP0DML2. Positions 29-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107829. 8 interactions.
STRINGi9606.ENSP00000316416.

Proteomic databases

PaxDbiP0DML2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316193; ENSP00000316416; ENSG00000136488.
GeneIDi1442.
KEGGihsa:1442.
UCSCiuc002jcs.3. human.

Organism-specific databases

CTDi1442.
GeneCardsiCSH1.
HGNCiHGNC:2440. CSH1.
HPAiHPA043715.
MIMi150200. gene.
neXtProtiNX_P0DML2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFR6. Eukaryota.
ENOG4111HU8. LUCA.
GeneTreeiENSGT00730000111012.
KOiK05438.
OMAiIDKHETQ.
PhylomeDBiP0DML2.

Enzyme and pathway databases

ReactomeiR-HSA-1170546. Prolactin receptor signaling.
R-HSA-982772. Growth hormone receptor signaling.

Miscellaneous databases

ChiTaRSiCSH1. human.
GenomeRNAii1442.
NextBioi5911.
PROiP0DML2.
SOURCEiSearch...

Gene expression databases

CleanExiHS_CSH1.
ExpressionAtlasiP0DML2. baseline and differential.
GenevisibleiP0DML2. HS.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of a major human chorionic somatomammotropin gene. Evidence for two functional promoter elements."
    Selby M.J., Barta A., Baxter J.D., Bell G.I., Eberhardt N.L.
    J. Biol. Chem. 259:13131-13138(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CSH1).
  2. "Two structurally different genes produce the same secreted human placental lactogen hormone."
    Barrera-Saldana H.A., Seeburg P.H., Saunders G.F.
    J. Biol. Chem. 258:3787-3793(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "The human growth hormone locus: nucleotide sequence, biology, and evolution."
    Chen E.Y., Liao Y.C., Smith D.H., Barrera-Saldana H.A., Gelinas R.E., Seeburg P.H.
    Genomics 4:479-497(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone."
    Seeburg P.H.
    DNA 1:239-249(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  5. "Complex signatures of locus-specific selective pressures and gene conversion on human growth hormone/chorionic somatomammotropin genes."
    Sedman L., Padhukasahasram B., Kelgo P., Laan M.
    Hum. Mutat. 29:1181-1193(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Uterus.
  8. "Construction and analysis of recombinant DNA for human chorionic somatomammotropin."
    Shine J., Seeburg P.H., Martial J.A., Baxter J.D., Goodman H.M.
    Nature 270:494-499(1977) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 50-217.
  9. "Amino acid sequence of human chorionic somatomammotropin."
    Li C.H., Dixon J.S., Chung D.
    Arch. Biochem. Biophys. 155:95-110(1973) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-217.
  10. "Amino-acid sequence of human placental lactogen."
    Sherwood L.M., Handwerger S., McLaurin W.D., Lanner M.
    Nature New Biol. 233:59-61(1971) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-217.
  11. Erratum
    Sherwood L.M., Handwerger S., McLaurin W.D., Lanner M.
    Nature New Biol. 235:64-64(1972)
  12. "Identification of the interchain disulfide bonds of dimeric human placental lactogen."
    Schneider A.B., Kowalski K., Russell J., Sherwood L.M.
    J. Biol. Chem. 254:3782-3787(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERCHAIN DISULFIDE BONDS, SUBUNIT.
  13. "Crystal structure and site 1 binding energetics of human placental lactogen."
    Walsh S.T., Kossiakoff A.A.
    J. Mol. Biol. 358:773-784(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 27-217, FUNCTION, ZINC-BINDING SITES, DISULFIDE BONDS.

Entry informationi

Entry nameiCSH1_HUMAN
AccessioniPrimary (citable) accession number: P0DML2
Secondary accession number(s): P01243, Q0VDB1, Q14407
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: July 9, 2014
Last modified: March 16, 2016
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

CSH1 sequence only differs from CSH2 sequence in 1 aa.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.