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Protein

Protein SETSIP

Gene

SETSIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role as a transcriptional activator involved in the early stage of somatic cell reprogramming. Promotes the differentiation of protein-induced pluripotent stem (PiPS) cells into endothelial cells and the formation of vascular-like tubes (in vitro). Involved in the transcription induction of vascular endothelial-cadherin (VE-cadherin) expression. Associates to the VE-cadherin gene promoter.1 Publication

Miscellaneous

Probable retrogene derived from SET transcript.

Caution

It is uncertain whether Met-1 or Met-11 is the initiator.Curated

GO - Molecular functioni

  • chromatin binding Source: UniProtKB

GO - Biological processi

  • endothelial cell differentiation Source: UniProtKB
  • nucleosome assembly Source: InterPro
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SETSIP
Alternative name(s):
SET pseudogene protein 18
SET similar protein
Similar to SET translocation protein
Gene namesi
Name:SETSIP
Synonyms:SETP18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000230667.5
HGNCiHGNC:42937 SETSIP
neXtProtiNX_P0DME0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000230667

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004260971 – 302Protein SETSIPAdd BLAST302

Proteomic databases

EPDiP0DME0
MaxQBiP0DME0
PeptideAtlasiP0DME0
PRIDEiP0DME0

PTM databases

iPTMnetiP0DME0
PhosphoSitePlusiP0DME0

Expressioni

Tissue specificityi

Expressed in endothelial cell (EC) and protein-induced pluripotent stem (PiPS) endothelial cell (EC) (at protein level).1 Publication

Inductioni

Up-regulated during protein-induced pluripotent stem (PiPS) endothelial cell differention. Up-regulated by VEGFA and POU2F1 (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000230667
ExpressionAtlasiP0DME0 baseline and differential

Organism-specific databases

HPAiHPA063683

Interactioni

Protein-protein interaction databases

BioGridi571638, 7 interactors
IntActiP0DME0, 1 interactor
MINTiP0DME0

Structurei

3D structure databases

ProteinModelPortaliP0DME0
SMRiP0DME0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili45 – 88Sequence analysisAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi218 – 302Asp-richAdd BLAST85

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1508 Eukaryota
ENOG410XQRX LUCA
GeneTreeiENSGT00530000062882
OMAiCLHYLTT
OrthoDBiEOG091G00YT

Family and domain databases

InterProiView protein in InterPro
IPR037231 NAP-like_sf
IPR002164 NAP_family
PANTHERiPTHR11875 PTHR11875, 1 hit
PfamiView protein in Pfam
PF00956 NAP, 1 hit
SUPFAMiSSF143113 SSF143113, 1 hit

Sequencei

Sequence statusi: Complete.

P0DME0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWFLDFPNS MAPKRQSPLP LQKKKPRPPP ALGLEETSAS AGLPKKGEKE
60 70 80 90 100
QQEAIEHIDE VQNEIDRLNE QDSEEILKVE QKYNKLRQPF FQKRSELIAK
110 120 130 140 150
IPNFGVTTFV NHPQVSSLLG EEDEEALHYL TKVEVTEFED IKSGYRIDFY
160 170 180 190 200
FDENPYFENK VFSKEFHLNE SGDPSSKSTK IKWKSGKDVT KRSSQTQNKA
210 220 230 240 250
SRKRQHEEPE SFFTWFTDHS DAGADELEEV IKDDIWPNPL QYYLVPDMDD
260 270 280 290 300
EEGGEDDDDD DDDGDEGEEE LEDIDEGDED EGEEDEDDDE GEEGEEDEGE

DD
Length:302
Mass (Da):34,882
Last modified:April 16, 2014 - v1
Checksum:i0A6D6A432D40A21B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104836 Genomic DNA No translation available.
CCDSiCCDS72821.1
RefSeqiNP_001274666.1, NM_001287737.1

Genome annotation databases

EnsembliENST00000596516; ENSP00000480946; ENSG00000230667
GeneIDi646817
KEGGihsa:646817
UCSCiuc031uhi.2 human

Similar proteinsi

Entry informationi

Entry nameiSETLP_HUMAN
AccessioniPrimary (citable) accession number: P0DME0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: March 28, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health