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Protein

Protein SETSIP

Gene

SETSIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role as a transcriptional activator involved in the early stage of somatic cell reprogramming. Promotes the differentiation of protein-induced pluripotent stem (PiPS) cells into endothelial cells and the formation of vascular-like tubes (in vitro). Involved in the transcription induction of vascular endothelial-cadherin (VE-cadherin) expression. Associates to the VE-cadherin gene promoter.1 Publication

GO - Molecular functioni

  • chromatin binding Source: UniProtKB

GO - Biological processi

  • endothelial cell differentiation Source: UniProtKB
  • nucleosome assembly Source: InterPro
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SETSIP
Alternative name(s):
SET pseudogene protein 18
SET similar protein
Similar to SET translocation protein
Gene namesi
Name:SETSIP
Synonyms:SETP18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:42937. SETSIP.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Protein SETSIPPRO_0000426097Add
BLAST

Proteomic databases

EPDiP0DME0.
PaxDbiP0DME0.
PeptideAtlasiP0DME0.

PTM databases

iPTMnetiP0DME0.
PhosphoSiteiP0DME0.

Expressioni

Tissue specificityi

Expressed in endothelial cell (EC) and protein-induced pluripotent stem (PiPS) endothelial cell (EC) (at protein level).1 Publication

Inductioni

Up-regulated during protein-induced pluripotent stem (PiPS) endothelial cell differention. Up-regulated by VEGFA and POU2F1 (at protein level).1 Publication

Gene expression databases

ExpressionAtlasiP0DME0. baseline.

Organism-specific databases

HPAiHPA063683.

Interactioni

Protein-protein interaction databases

BioGridi571638. 7 interactions.
IntActiP0DME0. 1 interaction.
STRINGi9606.ENSP00000361777.

Structurei

3D structure databases

ProteinModelPortaliP0DME0.
SMRiP0DME0. Positions 48-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili45 – 8844Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi218 – 30285Asp-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1508. Eukaryota.
ENOG410XQRX. LUCA.
GeneTreeiENSGT00530000062882.
OMAiNEYMETE.
OrthoDBiEOG091G00YT.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 1 hit.
PfamiPF00956. NAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0DME0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWFLDFPNS MAPKRQSPLP LQKKKPRPPP ALGLEETSAS AGLPKKGEKE
60 70 80 90 100
QQEAIEHIDE VQNEIDRLNE QDSEEILKVE QKYNKLRQPF FQKRSELIAK
110 120 130 140 150
IPNFGVTTFV NHPQVSSLLG EEDEEALHYL TKVEVTEFED IKSGYRIDFY
160 170 180 190 200
FDENPYFENK VFSKEFHLNE SGDPSSKSTK IKWKSGKDVT KRSSQTQNKA
210 220 230 240 250
SRKRQHEEPE SFFTWFTDHS DAGADELEEV IKDDIWPNPL QYYLVPDMDD
260 270 280 290 300
EEGGEDDDDD DDDGDEGEEE LEDIDEGDED EGEEDEDDDE GEEGEEDEGE

DD
Length:302
Mass (Da):34,882
Last modified:April 16, 2014 - v1
Checksum:i0A6D6A432D40A21B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104836 Genomic DNA. No translation available.
CCDSiCCDS72821.1.
RefSeqiNP_001274666.1. NM_001287737.1.

Genome annotation databases

EnsembliENST00000596516; ENSP00000480946; ENSG00000230667.
GeneIDi646817.
KEGGihsa:646817.
UCSCiuc031uhi.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104836 Genomic DNA. No translation available.
CCDSiCCDS72821.1.
RefSeqiNP_001274666.1. NM_001287737.1.

3D structure databases

ProteinModelPortaliP0DME0.
SMRiP0DME0. Positions 48-246.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi571638. 7 interactions.
IntActiP0DME0. 1 interaction.
STRINGi9606.ENSP00000361777.

PTM databases

iPTMnetiP0DME0.
PhosphoSiteiP0DME0.

Proteomic databases

EPDiP0DME0.
PaxDbiP0DME0.
PeptideAtlasiP0DME0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000596516; ENSP00000480946; ENSG00000230667.
GeneIDi646817.
KEGGihsa:646817.
UCSCiuc031uhi.2. human.

Organism-specific databases

CTDi646817.
GeneCardsiSETSIP.
HGNCiHGNC:42937. SETSIP.
HPAiHPA063683.
neXtProtiNX_P0DME0.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1508. Eukaryota.
ENOG410XQRX. LUCA.
GeneTreeiENSGT00530000062882.
OMAiNEYMETE.
OrthoDBiEOG091G00YT.

Miscellaneous databases

GenomeRNAii646817.
PROiP0DME0.

Gene expression databases

ExpressionAtlasiP0DME0. baseline.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 1 hit.
PfamiPF00956. NAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSETLP_HUMAN
AccessioniPrimary (citable) accession number: P0DME0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: September 7, 2016
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Probable retrogene derived from SET transcript.

Caution

It is uncertain whether Met-1 or Met-11 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.