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Protein

Transcriptional regulatory protein RcsA

Gene

rcsA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Rcs signaling system, which controls transcription of numerous genes. Binds, with RcsB, to the RcsAB box to regulate expression of genes involved in colanic acid capsule synthesis.UniRule annotation2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi155 – 174H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processCapsule biogenesis/degradation, Sensory transduction, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:PD02233

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein RcsAUniRule annotation
Alternative name(s):
Colanic acid capsular biosynthesis activation protein A
Gene namesi
Name:rcsAUniRule annotation
Ordered Locus Names:b1951, JW1935
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10820 rcsA

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi145M → V in rcsA*; increases stability and capsule synthesis. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001841781 – 207Transcriptional regulatory protein RcsAAdd BLAST207

Post-translational modificationi

Degraded by the Lon and the HslUV proteases (PubMed:1999391 and PubMed:14766922). Interaction with RcsB protects RcsA from degradation (PubMed:1999391).1 Publication

Proteomic databases

PaxDbiP0DMC9
PRIDEiP0DMC9

Expressioni

Inductioni

Autoregulated. Repressed by H-NS. Induced by the DsrA small regulatory RNA, which inhibits the H-NS mediated transcriptional silencing.2 Publications

Interactioni

Subunit structurei

Interacts with RcsB.UniRule annotation1 Publication

Protein-protein interaction databases

BioGridi4261047, 8 interactors
IntActiP0DMC9, 29 interactors
STRINGi316385.ECDH10B_2093

Structurei

3D structure databases

ProteinModelPortaliP0DMC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 196HTH luxR-typeUniRule annotationAdd BLAST66

Sequence similaritiesi

Belongs to the RcsA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107TKS Bacteria
COG2771 LUCA
KOiK07781
OMAiPGVVFIN

Family and domain databases

CDDicd06170 LuxR_C_like, 1 hit
Gene3Di1.10.10.10, 1 hit
HAMAPiMF_00982 RcsA, 1 hit
InterProiView protein in InterPro
IPR030866 RcsA
IPR016032 Sig_transdc_resp-reg_C-effctor
IPR000792 Tscrpt_reg_LuxR_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00196 GerE, 1 hit
PRINTSiPR00038 HTHLUXR
SMARTiView protein in SMART
SM00421 HTH_LUXR, 1 hit
SUPFAMiSSF46894 SSF46894, 1 hit
PROSITEiView protein in PROSITE
PS00622 HTH_LUXR_1, 1 hit
PS50043 HTH_LUXR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0DMC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTIIMDLCS YTRLGLTGYL LSRGVKKREI NDIETVDDLA IACDSQRPSV
60 70 80 90 100
VFINEDCFIH DASNSQRIKL IINQHPNTLF IVFMAIANVH FDEYLLVRKN
110 120 130 140 150
LLISSKSIKP ESLDDILGDI LKKETTITSF LNMPTLSLSR TESSMLRMWM
160 170 180 190 200
AGQGTIQISD QMNIKAKTVS SHKGNIKRKI KTHNKQVIYH VVRLTDNVTN

GIFVNMR
Length:207
Mass (Da):23,516
Last modified:February 19, 2014 - v1
Checksum:i6DAA22097807AF62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58003 Genomic DNA Translation: AAA82970.1
U00096 Genomic DNA Translation: AAC75018.1
AP009048 Genomic DNA Translation: BAA15776.1
U17137 Genomic DNA Translation: AAC43315.1
PIRiA37320
RefSeqiNP_416461.1, NC_000913.3
WP_000104001.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75018; AAC75018; b1951
BAA15776; BAA15776; BAA15776
GeneIDi946467
KEGGiecj:JW1935
eco:b1951
PATRICifig|1411691.4.peg.300

Entry informationi

Entry nameiRCSA_ECOLI
AccessioniPrimary (citable) accession number: P0DMC9
Secondary accession number(s): P24210, P69405, Q47585
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 19, 2014
Last sequence update: February 19, 2014
Last modified: March 28, 2018
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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