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Protein

Actin-1

Gene

act-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

GO - Molecular functioni

GO - Biological processi

  • cortical actin cytoskeleton organization Source: WormBase
  • embryo development ending in birth or egg hatching Source: WormBase
  • mitotic cytokinesis Source: WormBase
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-1
Gene namesi
Name:act-1
ORF Names:T04C12.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT04C12.6; CE13148; WBGene00000063; act-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000006501 – 2Removed in mature formBy similarity2
ChainiPRO_00000006513 – 376Actin-1Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3N-acetylaspartateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP0DM41.
PaxDbiP0DM41.
PeptideAtlasiP0DM41.
PRIDEiP0DM41.

Expressioni

Gene expression databases

BgeeiWBGene00000063.
ExpressionAtlasiP0DM41. differential.

Interactioni

Protein-protein interaction databases

BioGridi44560. 1 interactor.
44562. 10 interactors.
MINTiMINT-1129266.
STRINGi6239.T04C12.6.3.

Structurei

Secondary structure

1376
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 13Combined sources5
Beta strandi15 – 22Combined sources8
Beta strandi25 – 27Combined sources3
Beta strandi29 – 33Combined sources5
Beta strandi36 – 42Combined sources7
Helixi57 – 61Combined sources5
Helixi63 – 65Combined sources3
Beta strandi66 – 69Combined sources4
Helixi80 – 92Combined sources13
Turni93 – 95Combined sources3
Helixi99 – 101Combined sources3
Beta strandi104 – 108Combined sources5
Helixi114 – 126Combined sources13
Beta strandi131 – 137Combined sources7
Helixi138 – 145Combined sources8
Beta strandi149 – 159Combined sources11
Beta strandi161 – 167Combined sources7
Helixi173 – 175Combined sources3
Beta strandi177 – 180Combined sources4
Helixi183 – 195Combined sources13
Turni196 – 198Combined sources3
Helixi204 – 217Combined sources14
Helixi224 – 233Combined sources10
Beta strandi235 – 237Combined sources3
Beta strandi239 – 242Combined sources4
Beta strandi244 – 246Combined sources3
Beta strandi248 – 251Combined sources4
Helixi254 – 263Combined sources10
Helixi265 – 268Combined sources4
Helixi275 – 284Combined sources10
Helixi288 – 290Combined sources3
Helixi291 – 295Combined sources5
Beta strandi298 – 302Combined sources5
Helixi303 – 305Combined sources3
Helixi310 – 321Combined sources12
Turni334 – 337Combined sources4
Helixi339 – 349Combined sources11
Helixi351 – 353Combined sources3
Turni354 – 356Combined sources3
Beta strandi357 – 359Combined sources3
Helixi360 – 366Combined sources7
Helixi368 – 370Combined sources3
Helixi371 – 374Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D4XX-ray1.75A2-376[»]
ProteinModelPortaliP0DM41.
SMRiP0DM41.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
KOiK05692.
OrthoDBiEOG091G08LD.
PhylomeDBiP0DM41.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DM41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDDEVAALV VDNGSGMCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ
60 70 80 90 100
KDSYVGDEAQ SKRGILTLKY PIEHGIVTNW DDMEKIWHHT FYNELRVAPE
110 120 130 140 150
EHPVLLTEAP LNPKANREKM TQIMFETFNT PAMYVAIQAV LSLYASGRTT
160 170 180 190 200
GVVLDSGDGV THTVPIYEGY ALPHAILRLD LAGRDLTDYL MKILTERGYS
210 220 230 240 250
FTTTAEREIV RDIKEKLCYV ALDFEQEMAT AASSSSLEKS YELPDGQVIT
260 270 280 290 300
VGNERFRCPE AMFQPSFLGM ESAGIHETSY NSIMKCDIDI RKDLYANTVL
310 320 330 340 350
SGGTTMYPGI ADRMQKEITA LAPSTMKIKI IAPPERKYSV WIGGSILASL
360 370
STFQQMWISK QEYDESGPSI VHRKCF
Length:376
Mass (Da):41,796
Last modified:June 26, 2013 - v1
Checksum:iBCF86DE909D4EE0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16796 Genomic DNA. Translation: CAA34717.1.
Z81584 Genomic DNA. Translation: CAB04678.1.
J01042 Genomic DNA. Translation: AAA27887.1.
PIRiS16710.
RefSeqiNP_505817.1. NM_073416.6.
NP_505819.1. NM_073418.5.
UniGeneiCel.24742.
Cel.34750.

Genome annotation databases

EnsemblMetazoaiT04C12.4.1; T04C12.4.1; WBGene00000065.
T04C12.4.2; T04C12.4.2; WBGene00000065.
T04C12.4.3; T04C12.4.3; WBGene00000065.
T04C12.6.1; T04C12.6.1; WBGene00000063.
T04C12.6.2; T04C12.6.2; WBGene00000063.
T04C12.6.3; T04C12.6.3; WBGene00000063.
T04C12.6.4; T04C12.6.4; WBGene00000063.
GeneIDi179533.
179535.
KEGGicel:CELE_T04C12.4.
cel:CELE_T04C12.6.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16796 Genomic DNA. Translation: CAA34717.1.
Z81584 Genomic DNA. Translation: CAB04678.1.
J01042 Genomic DNA. Translation: AAA27887.1.
PIRiS16710.
RefSeqiNP_505817.1. NM_073416.6.
NP_505819.1. NM_073418.5.
UniGeneiCel.24742.
Cel.34750.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D4XX-ray1.75A2-376[»]
ProteinModelPortaliP0DM41.
SMRiP0DM41.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44560. 1 interactor.
44562. 10 interactors.
MINTiMINT-1129266.
STRINGi6239.T04C12.6.3.

Proteomic databases

EPDiP0DM41.
PaxDbiP0DM41.
PeptideAtlasiP0DM41.
PRIDEiP0DM41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT04C12.4.1; T04C12.4.1; WBGene00000065.
T04C12.4.2; T04C12.4.2; WBGene00000065.
T04C12.4.3; T04C12.4.3; WBGene00000065.
T04C12.6.1; T04C12.6.1; WBGene00000063.
T04C12.6.2; T04C12.6.2; WBGene00000063.
T04C12.6.3; T04C12.6.3; WBGene00000063.
T04C12.6.4; T04C12.6.4; WBGene00000063.
GeneIDi179533.
179535.
KEGGicel:CELE_T04C12.4.
cel:CELE_T04C12.6.

Organism-specific databases

CTDi179533.
179535.
WormBaseiT04C12.6; CE13148; WBGene00000063; act-1.

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
KOiK05692.
OrthoDBiEOG091G08LD.
PhylomeDBiP0DM41.

Miscellaneous databases

PROiP0DM41.

Gene expression databases

BgeeiWBGene00000063.
ExpressionAtlasiP0DM41. differential.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACT1_CAEEL
AccessioniPrimary (citable) accession number: P0DM41
Secondary accession number(s): P10983, P10985
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2013
Last sequence update: June 26, 2013
Last modified: November 30, 2016
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Miscellaneous

In this organism there are four genes coding for actin. The sequences coded by genes 1 and 3 are identical. There are a few variations in the actins coded by genes 2 and 4.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.