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Protein

Actin-1

Gene

act-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

GO - Molecular functioni

GO - Biological processi

  • cortical actin cytoskeleton organization Source: WormBase
  • embryo development ending in birth or egg hatching Source: WormBase
  • mitotic cytokinesis Source: WormBase
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-1
Gene namesi
Name:act-1
ORF Names:T04C12.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT04C12.6; CE13148; WBGene00000063; act-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 22Removed in mature formBy similarityPRO_0000000650
Chaini3 – 376374Actin-1PRO_0000000651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei3 – 31N-acetylaspartateBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP0DM41.
PaxDbiP0DM41.

Expressioni

Gene expression databases

BgeeiWBGene00000063.
ExpressionAtlasiP0DM41. baseline.

Interactioni

Protein-protein interaction databases

BioGridi44560. 1 interaction.
44562. 10 interactions.
MINTiMINT-1129266.
STRINGi6239.T04C12.6.3.

Structurei

Secondary structure

1
376
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 135Combined sources
Beta strandi15 – 228Combined sources
Beta strandi25 – 273Combined sources
Beta strandi29 – 335Combined sources
Beta strandi36 – 427Combined sources
Helixi57 – 615Combined sources
Helixi63 – 653Combined sources
Beta strandi66 – 694Combined sources
Helixi80 – 9213Combined sources
Turni93 – 953Combined sources
Helixi99 – 1013Combined sources
Beta strandi104 – 1085Combined sources
Helixi114 – 12613Combined sources
Beta strandi131 – 1377Combined sources
Helixi138 – 1458Combined sources
Beta strandi149 – 15911Combined sources
Beta strandi161 – 1677Combined sources
Helixi173 – 1753Combined sources
Beta strandi177 – 1804Combined sources
Helixi183 – 19513Combined sources
Turni196 – 1983Combined sources
Helixi204 – 21714Combined sources
Helixi224 – 23310Combined sources
Beta strandi235 – 2373Combined sources
Beta strandi239 – 2424Combined sources
Beta strandi244 – 2463Combined sources
Beta strandi248 – 2514Combined sources
Helixi254 – 26310Combined sources
Helixi265 – 2684Combined sources
Helixi275 – 28410Combined sources
Helixi288 – 2903Combined sources
Helixi291 – 2955Combined sources
Beta strandi298 – 3025Combined sources
Helixi303 – 3053Combined sources
Helixi310 – 32112Combined sources
Turni334 – 3374Combined sources
Helixi339 – 34911Combined sources
Helixi351 – 3533Combined sources
Turni354 – 3563Combined sources
Beta strandi357 – 3593Combined sources
Helixi360 – 3667Combined sources
Helixi368 – 3703Combined sources
Helixi371 – 3744Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D4XX-ray1.75A2-376[»]
ProteinModelPortaliP0DM41.
SMRiP0DM41. Positions 5-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
KOiK05692.
OrthoDBiEOG091G08LD.
PhylomeDBiP0DM41.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DM41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDDEVAALV VDNGSGMCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ
60 70 80 90 100
KDSYVGDEAQ SKRGILTLKY PIEHGIVTNW DDMEKIWHHT FYNELRVAPE
110 120 130 140 150
EHPVLLTEAP LNPKANREKM TQIMFETFNT PAMYVAIQAV LSLYASGRTT
160 170 180 190 200
GVVLDSGDGV THTVPIYEGY ALPHAILRLD LAGRDLTDYL MKILTERGYS
210 220 230 240 250
FTTTAEREIV RDIKEKLCYV ALDFEQEMAT AASSSSLEKS YELPDGQVIT
260 270 280 290 300
VGNERFRCPE AMFQPSFLGM ESAGIHETSY NSIMKCDIDI RKDLYANTVL
310 320 330 340 350
SGGTTMYPGI ADRMQKEITA LAPSTMKIKI IAPPERKYSV WIGGSILASL
360 370
STFQQMWISK QEYDESGPSI VHRKCF
Length:376
Mass (Da):41,796
Last modified:June 26, 2013 - v1
Checksum:iBCF86DE909D4EE0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16796 Genomic DNA. Translation: CAA34717.1.
Z81584 Genomic DNA. Translation: CAB04678.1.
J01042 Genomic DNA. Translation: AAA27887.1.
PIRiS16710.
RefSeqiNP_505817.1. NM_073416.6.
NP_505819.1. NM_073418.5.
UniGeneiCel.24742.
Cel.34750.

Genome annotation databases

EnsemblMetazoaiT04C12.4.1; T04C12.4.1; WBGene00000065.
T04C12.4.2; T04C12.4.2; WBGene00000065.
T04C12.4.3; T04C12.4.3; WBGene00000065.
T04C12.6.1; T04C12.6.1; WBGene00000063.
T04C12.6.2; T04C12.6.2; WBGene00000063.
T04C12.6.3; T04C12.6.3; WBGene00000063.
T04C12.6.4; T04C12.6.4; WBGene00000063.
GeneIDi179533.
179535.
KEGGicel:CELE_T04C12.4.
cel:CELE_T04C12.6.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16796 Genomic DNA. Translation: CAA34717.1.
Z81584 Genomic DNA. Translation: CAB04678.1.
J01042 Genomic DNA. Translation: AAA27887.1.
PIRiS16710.
RefSeqiNP_505817.1. NM_073416.6.
NP_505819.1. NM_073418.5.
UniGeneiCel.24742.
Cel.34750.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D4XX-ray1.75A2-376[»]
ProteinModelPortaliP0DM41.
SMRiP0DM41. Positions 5-376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44560. 1 interaction.
44562. 10 interactions.
MINTiMINT-1129266.
STRINGi6239.T04C12.6.3.

Proteomic databases

EPDiP0DM41.
PaxDbiP0DM41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT04C12.4.1; T04C12.4.1; WBGene00000065.
T04C12.4.2; T04C12.4.2; WBGene00000065.
T04C12.4.3; T04C12.4.3; WBGene00000065.
T04C12.6.1; T04C12.6.1; WBGene00000063.
T04C12.6.2; T04C12.6.2; WBGene00000063.
T04C12.6.3; T04C12.6.3; WBGene00000063.
T04C12.6.4; T04C12.6.4; WBGene00000063.
GeneIDi179533.
179535.
KEGGicel:CELE_T04C12.4.
cel:CELE_T04C12.6.

Organism-specific databases

CTDi179533.
179535.
WormBaseiT04C12.6; CE13148; WBGene00000063; act-1.

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
KOiK05692.
OrthoDBiEOG091G08LD.
PhylomeDBiP0DM41.

Miscellaneous databases

PROiP0DM41.

Gene expression databases

BgeeiWBGene00000063.
ExpressionAtlasiP0DM41. baseline.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACT1_CAEEL
AccessioniPrimary (citable) accession number: P0DM41
Secondary accession number(s): P10983, P10985
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2013
Last sequence update: June 26, 2013
Last modified: September 7, 2016
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Miscellaneous

In this organism there are four genes coding for actin. The sequences coded by genes 1 and 3 are identical. There are a few variations in the actins coded by genes 2 and 4.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.