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Protein

Metallothionein 1H-like protein 1

Gene

MT1HL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster BBy similarity1
Metal bindingi7Divalent metal cation; cluster BBy similarity1
Metal bindingi15Divalent metal cation; cluster BBy similarity1
Metal bindingi19Divalent metal cation; cluster BBy similarity1
Metal bindingi21Divalent metal cation; cluster BBy similarity1
Metal bindingi24Divalent metal cation; cluster BBy similarity1
Metal bindingi26Divalent metal cation; cluster BBy similarity1
Metal bindingi29Divalent metal cation; cluster BBy similarity1
Metal bindingi33Divalent metal cation; cluster ABy similarity1
Metal bindingi34Divalent metal cation; cluster ABy similarity1
Metal bindingi36Divalent metal cation; cluster ABy similarity1
Metal bindingi37Divalent metal cation; cluster ABy similarity1
Metal bindingi41Divalent metal cation; cluster ABy similarity1
Metal bindingi44Divalent metal cation; cluster ABy similarity1
Metal bindingi48Divalent metal cation; cluster ABy similarity1
Metal bindingi57Divalent metal cation; cluster ABy similarity1
Metal bindingi59Divalent metal cation; cluster ABy similarity1
Metal bindingi60Divalent metal cation; cluster ABy similarity1

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein 1H-like protein 1
Gene namesi
Name:MT1HL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000244020.2.
HGNCiHGNC:31864. MT1HL1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000244020.

Polymorphism and mutation databases

DMDMi510120661.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004225421 – 61Metallothionein 1H-like protein 1Add BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PeptideAtlasiP0DM35.
PRIDEiP0DM35.

PTM databases

PhosphoSitePlusiP0DM35.

Expressioni

Gene expression databases

BgeeiENSG00000244020.
GenevisibleiP0DM35. HS.

Structurei

3D structure databases

ProteinModelPortaliP0DM35.
SMRiP0DM35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni30 – 61AlphaAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 60Cys-richAdd BLAST56

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines (By similarity).By similarity

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00730000111764.
InParanoidiP0DM35.
KOiK14739.
OMAiCACKEAS.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR003019. Metalthion.
IPR017854. Metalthion_dom_sf.
IPR023587. Metalthion_dom_sf_vert.
IPR000006. Metalthion_vert.
IPR001368. TNFR/NGFR_Cys_rich_reg.
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiView protein in Pfam
PF00131. Metallothio. 1 hit.
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.

Sequencei

Sequence statusi: Complete.

P0DM35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPNCSCAAG GSYACAGSCK CKKCKCTSCK KSCCSCCPLG CAKCAQGCIR
60
KGASEKCSCC A
Length:61
Mass (Da):6,094
Last modified:May 29, 2013 - v1
Checksum:iE60ABD8D8130B9A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333388 mRNA. Translation: AAK18278.1.
AL359259 Genomic DNA. No translation available.
CCDSiCCDS31068.1.
RefSeqiNP_001263616.1. NM_001276687.1.
UniGeneiHs.632513.

Genome annotation databases

EnsembliENST00000464121; ENSP00000476141; ENSG00000244020.
GeneIDi645745.
KEGGihsa:645745.
UCSCiuc001hyk.2. human.

Similar proteinsi

Entry informationi

Entry nameiM1BL1_HUMAN
AccessioniPrimary (citable) accession number: P0DM35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2013
Last sequence update: May 29, 2013
Last modified: December 20, 2017
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Encoded by an expressed retrotransposed copy of the MT1H locus.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families