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Protein

Conotoxin De13.1

Gene
N/A
Organism
Conus delessertii (Sozon's cone) (Conus sozoni)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionToxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin De13.1
Alternative name(s):
de13b
OrganismiConus delessertii (Sozon's cone) (Conus sozoni)
Taxonomic identifieri348592 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000042242520 – 35By similarityAdd BLAST16
ChainiPRO_000042242638 – 69Conotoxin De13.1Add BLAST32

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei404-hydroxyprolineBy similarity1
Modified residuei444-hydroxyprolineBy similarity1
Modified residuei516'-bromotryptophanBy similarity1
Modified residuei524-carboxyglutamate1 Publication1
Modified residuei555-hydroxylysineBy similarity1
Modified residuei584-hydroxyprolineBy similarity1
Modified residuei69Histidine amideBy similarity1

Post-translational modificationi

Contains 4 disulfide bonds.

Keywords - PTMi

Amidation, Bromination, Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Domaini

The cysteine framework is XIII (C-C-C-CC-C-C-C).

Sequence similaritiesi

Belongs to the conotoxin G superfamily.Curated

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DM34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGMGVLLLV LLLVMPLAAF HQDGEGEATR RSGGLKRDCP TSCPTTCANG
60 70
WECCKGYPCV RQHCSGCNHG K
Length:71
Mass (Da):7,554
Last modified:May 29, 2013 - v1
Checksum:i888A81EE0DD91AD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KC782513 mRNA. Translation: AGO59814.1.

Entry informationi

Entry nameiCDB_CONDE
AccessioniPrimary (citable) accession number: P0DM34
Secondary accession number(s): S4V9Q1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2013
Last sequence update: May 29, 2013
Last modified: November 22, 2017
This is version 10 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families