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Protein

Potassium channel toxin alpha-KTx 16.9

Gene
N/A
Organism
Buthus paris (Scorpion) (Buthus occitanus paris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Poorly competes with (125)I-kaliotoxin binding on rat brain synaptosome (IC50>100 nM). Is a poor Kv1.3/KCNA3 ligand (PubMed:23523531). May have as real target KCa1.1/KCNMA1 channel (By similarity). Shows weak toxicity on mice (PubMed:23523531).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei27Basic residue of the functional dyadBy similarity1
Sitei36Aromatic residue of the functional dyadBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium-activated potassium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 16.91 Publication
Alternative name(s):
Toxin BoP21 Publication
OrganismiButhus paris (Scorpion) (Buthus occitanus paris)
Taxonomic identifieri1388771 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeButhus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 14 µg/kg by intracerebroventricular injection into mice.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004331461 – 36Potassium channel toxin alpha-KTx 16.91 PublicationAdd BLAST36

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7 ↔ 28By similarity
Disulfide bondi13 ↔ 33By similarity
Disulfide bondi17 ↔ 35By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Structurei

3D structure databases

SMRiP0DL46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiView protein in InterPro
IPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
PfamiView protein in Pfam
PF00451. Toxin_2. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003586. Scorpion_toxinS. 1 hit.
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiView protein in PROSITE
PS01138. SCORP_SHORT_TOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P0DL46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
GLIDVRCYAS RECWEPCRKV TGSGQAKCQN NQCRCY
Length:36
Mass (Da):4,127
Last modified:May 27, 2015 - v1
Checksum:i04C7250B01A87227
GO

Mass spectrometryi

Molecular mass is 4121 Da from positions 1 - 36. Determined by MALDI. 1 Publication

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKA169_BUTPA
AccessioniPrimary (citable) accession number: P0DL46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2015
Last sequence update: May 27, 2015
Last modified: May 10, 2017
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families