UniProtKB - P0DL46 (KA169_BUTPA)
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Protein
Potassium channel toxin alpha-KTx 16.9
Gene
N/A
Organism
Buthus paris (Scorpion) (Buthus occitanus paris)
Status
Functioni
Poorly competes with (125)I-kaliotoxin binding on rat brain synaptosome (IC50>100 nM). Is a poor Kv1.3/KCNA3 ligand (PubMed:23523531). May have as real target KCa1.1/KCNMA1 channel (By similarity). Shows weak toxicity on mice (PubMed:23523531).By similarity1 Publication
Sites
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Sitei | 27 | Basic residue of the functional dyadBy similarity | 1 | |
| Sitei | 36 | Aromatic residue of the functional dyadBy similarity | 1 |
GO - Molecular functioni
- ion channel inhibitor activity Source: InterPro
GO - Biological processi
- defense response Source: InterPro
- pathogenesis Source: InterPro
Keywordsi
| Molecular function | Calcium-activated potassium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin |
Names & Taxonomyi
| Protein namesi | Recommended name: Potassium channel toxin alpha-KTx 16.91 PublicationAlternative name(s): Toxin BoP21 Publication |
| Organismi | Buthus paris (Scorpion) (Buthus occitanus paris) |
| Taxonomic identifieri | 1388771 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Buthus |
Subcellular locationi
- Secreted 1 Publication
GO - Cellular componenti
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Toxic dosei
LD50 is 14 µg/kg by intracerebroventricular injection into mice.1 Publication
PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| ChainiPRO_0000433146 | 1 – 36 | Potassium channel toxin alpha-KTx 16.91 PublicationAdd BLAST | 36 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Disulfide bondi | 7 ↔ 28 | By similarity | ||
| Disulfide bondi | 13 ↔ 33 | By similarity | ||
| Disulfide bondi | 17 ↔ 35 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.Curated
Family & Domainsi
Domaini
Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).By similarity
Sequence similaritiesi
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 16 subfamily.Curated
Family and domain databases
| Gene3Di | 3.30.30.10. 1 hit. |
| InterProi | View protein in InterPro IPR003614. Scorpion_toxin-like. IPR001947. Scorpion_toxinS_K_inh. |
| Pfami | View protein in Pfam PF00451. Toxin_2. 1 hit. |
| ProDomi | View protein in ProDom or Entries sharing at least one domain PD003586. Scorpion_toxinS. 1 hit. |
| SUPFAMi | SSF57095. SSF57095. 1 hit. |
| PROSITEi | View protein in PROSITE PS01138. SCORP_SHORT_TOXIN. 1 hit. |
Sequencei
Sequence statusi: Complete.
Mass spectrometryi
Similar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:| 100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry. |
| 90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
| 50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |
Entry informationi
| Entry namei | KA169_BUTPA | |
| Accessioni | P0DL46Primary (citable) accession number: P0DL46 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 27, 2015 |
| Last sequence update: | May 27, 2015 | |
| Last modified: | May 10, 2017 | |
| This is version 4 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Animal Toxin Annotation Program | |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries - SIMILARITY comments
Index of protein domains and families
