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Protein

Conantokin-R1-C

Gene
N/A
Organism
Conus rolani (Cone snail)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin has antagonist activity on NR2B/GRIN2B (IC50=1.4 µM) and NR2A/GRIN2A (IC50=2.9 µM) subunits, when tested on rat receptors.1 Publication

Miscellaneous

The mature peptide does not contain cysteine residue.Curated
Has no antagonist activity on NR2C/GRIN2C, and NR2D/GRIN2D subunits.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Ionotropic glutamate receptor inhibitor, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conantokin-R1-C
Short name:
Con-R1-C
OrganismiConus rolani (Cone snail)
Taxonomic identifieri745791 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri5850. Conantokin-Rl3 precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000042189622 – 78By similarityAdd BLAST57
PeptideiPRO_000042189779 – 96Conantokin-R1-CAdd BLAST18

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei814-carboxyglutamateBy similarity1
Modified residuei824-carboxyglutamateBy similarity1
Modified residuei854-carboxyglutamateBy similarity1
Modified residuei894-carboxyglutamateBy similarity1
Modified residuei934-carboxyglutamateBy similarity1
Modified residuei96Asparagine amideBy similarity1

Keywords - PTMi

Amidation, Gamma-carboxyglutamic acid

Expressioni

Tissue specificityi

Expressed by the venom duct.Curated

Family & Domainsi

Sequence similaritiesi

Belongs to the conotoxin B superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR005918. Conantokin_CS.
PROSITEiView protein in PROSITE
PS60025. CONANTOKIN. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DKZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLYTYLYLL VPLVTFHLIL GTGTLDHGDA LTERRSADAT ALKPEPVLLQ
60 70 80 90
KSSARSTDDN GKDTQMKRIF KKRRNKARGE EELSENAVEF ARELAN
Length:96
Mass (Da):10,864
Last modified:April 3, 2013 - v1
Checksum:i37B5511265166809
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei961

Similar proteinsi

Entry informationi

Entry nameiCKR1C_CONRO
AccessioniPrimary (citable) accession number: P0DKZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2013
Last sequence update: April 3, 2013
Last modified: November 22, 2017
This is version 10 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families