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Protein

Cyclolysin secretion/processing ATP-binding protein CyaB

Gene

cyaB

Organism
Bordetella pertussis (strain ATCC 9797 / DSM 5571 / NCTC 10739 / 18323)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the export of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi505 – 512ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processCytolysis, Hemolysis, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclolysin secretion/processing ATP-binding protein CyaB (EC:3.4.22.-)
Gene namesi
Name:cyaB
Ordered Locus Names:BN118_0469
OrganismiBordetella pertussis (strain ATCC 9797 / DSM 5571 / NCTC 10739 / 18323)
Taxonomic identifieri568706 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000005250 Componenti: Chromosome

Subcellular locationi

P0DKX6:

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei160 – 180HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei194 – 214HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei272 – 292HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei298 – 318HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei367 – 387HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei390 – 410HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004213021 – 712Cyclolysin secretion/processing ATP-binding protein CyaBAdd BLAST712

Structurei

3D structure databases

SMRiP0DKX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 128Peptidase C39PROSITE-ProRule annotationAdd BLAST122
Domaini157 – 439ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST283
Domaini471 – 706ABC transporterPROSITE-ProRule annotationAdd BLAST236

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR010132. ATPase_T1SS_HlyB.
IPR027417. P-loop_NTPase.
IPR005074. Peptidase_C39.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
PF03412. Peptidase_C39. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR01846. type_I_sec_HlyB. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS50990. PEPTIDASE_C39. 1 hit.

Sequencei

Sequence statusi: Complete.

P0DKX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSPVAQCAS VPDSGLLCLV MLARYHGLAA DPEQLRHEFA EQAFCSETIQ
60 70 80 90 100
LAARRVGLKV RRHRPAPARL PRAPLPAIAL DRQGGYFVLA RFEPGADQAV
110 120 130 140 150
LIQRPGQAPA RLGQAEFEAL WAGELLLCAC AASPTQALAR FDFSWFIPAL
160 170 180 190 200
VKHRHLIGEV LLISLVLQFI SLLTPLFFQV VMDKVLVNNA METLNVIAVG
210 220 230 240 250
FLAAILFEAL LTGIRTYLFA HTSSKLDVEL GARLYAHLLR LPLAYFQARR
260 270 280 290 300
VGDSVARVRE LEHIRAFLTG NAVTVLLDVV FSVVFIAVMF FYSVKLTLVV
310 320 330 340 350
LAALPCYFLL SLVLTPVLRR RLDVKFNRGA ENQAFLVETV SGIDTVKSLA
360 370 380 390 400
VEPQWQRNWD RQLAGYVAAG LSVANVAMLA NTGVTLISRL VALGVLWVGA
410 420 430 440 450
TEVVAQRMTV GELVAFNMLS GHVTQPVIRL AQLWNDFQQT GVSMQRLGDI
460 470 480 490 500
LNCRTEVAGD KAQLPALRGS IELDRVSFRY RPDAADALRN VSLRIAPGEV
510 520 530 540 550
VGVVGRSGSG KSTLTRLIQR MFVADRGRVL IDGHDIGIVD SASLRRQLGV
560 570 580 590 600
VLQESTLFNR SVRDNIALTR PGASMHEVVA AARLAGAHEF ICQLPEGYDT
610 620 630 640 650
MLGENGVGLS GGQRQRIGIA RALIHRPRVL ILDEATSALD YESEHIIQRN
660 670 680 690 700
MRDICDGRTV IIIAHRLSAV RCADRIVVME GGEVAECGSH ETLLAAGGLY
710
ARLQALQAGE AG
Length:712
Mass (Da):77,662
Last modified:March 6, 2013 - v1
Checksum:iE928BF3B37775820
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90A → VP in CAA32412 (PubMed:2905265).Curated1
Sequence conflicti198A → T in CAA32412 (PubMed:2905265).Curated1
Sequence conflicti323D → H in CAA32412 (PubMed:2905265).Curated1
Sequence conflicti391 – 406VALGV…EVVAQ → LRWESCGWAHRGGRA in CAA32412 (PubMed:2905265).CuratedAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14199 Genomic DNA. Translation: CAA32412.1.
HE965805 Genomic DNA. No translation available.
PIRiS02386. BVBRCB.
RefSeqiWP_041166126.1. NC_018518.1.

Similar proteinsi

Entry informationi

Entry nameiCYAB_BORP1
AccessioniPrimary (citable) accession number: P0DKX6
Secondary accession number(s): P18770
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: March 6, 2013
Last modified: October 25, 2017
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families