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Protein

Arsenate-mycothiol transferase ArsC2

Gene

arsC2

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in defense against toxic arsenate. Involved in the mycothiol/myoredoxin redox pathway which uses a mycothioltransferase mechanism; facilitates adduct formation between arsenate and mycothiol.1 Publication

Catalytic activityi

Arsenate + mycothiol = arseno-mycothiol + H2O.1 Publication

Kineticsi

  1. KM=142 mM for arsenate in the presence of mycoredoxin 1, mycothiol, mycothione reductase and NADPH1 Publication

    GO - Molecular functioni

    GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Arsenical resistance

    Enzyme and pathway databases

    BRENDAi2.8.4.2. 960.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arsenate-mycothiol transferase ArsC2 (EC:2.8.4.2)
    Alternative name(s):
    Mycothiol-dependent arsenate reductase ArsC2
    Gene namesi
    Name:arsC2
    Synonyms:arsX
    Ordered Locus Names:cg0319, Cgl0263
    OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
    Taxonomic identifieri196627 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
    Proteomesi
    • UP000000582 Componenti: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 129129Arsenate-mycothiol transferase ArsC2PRO_0000418725Add
    BLAST

    Expressioni

    Inductioni

    By arsenite.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi196627.cg0319.

    Structurei

    Secondary structure

    1
    129
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 1311Combined sources
    Helixi14 – 2512Combined sources
    Beta strandi30 – 389Combined sources
    Helixi45 – 539Combined sources
    Helixi68 – 736Combined sources
    Beta strandi75 – 839Combined sources
    Beta strandi94 – 996Combined sources
    Helixi108 – 12720Combined sources

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3RH0X-ray1.72A/B1-129[»]
    ProteinModelPortaliP0DKS7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0394. LUCA.
    KOiK18701.
    OMAiELRSCEY.

    Family and domain databases

    InterProiIPR023485. Ptyr_pPase_SF.
    [Graphical view]
    PfamiPF01451. LMWPc. 1 hit.
    [Graphical view]
    SMARTiSM00226. LMWPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52788. SSF52788. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0DKS7-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MKSVLFVCVG NGGKSQMAAA LAQKYASDSV EIHSAGTKPA QGLNQLSVES
    60 70 80 90 100
    IAEVGADMSQ GIPKAIDPEL LRTVDRVVIL GDDAQVDMPE SAQGALERWS
    110 120
    IEEPDAQGME RMRIVRDQID NRVQALLAG
    Length:129
    Mass (Da):13,763
    Last modified:January 9, 2013 - v1
    Checksum:i9279EF21FF0E52B8
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    BA000036 Genomic DNA. Translation: BAB97656.1.
    BX927148 Genomic DNA. Translation: CAF18834.1.
    RefSeqiNP_599516.1. NC_003450.3.
    WP_003863342.1. NC_006958.1.

    Genome annotation databases

    EnsemblBacteriaiBAB97656; BAB97656; BAB97656.
    CAF18834; CAF18834; cg0319.
    GeneIDi1021323.
    KEGGicgb:cg0319.
    cgl:NCgl0259.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    BA000036 Genomic DNA. Translation: BAB97656.1.
    BX927148 Genomic DNA. Translation: CAF18834.1.
    RefSeqiNP_599516.1. NC_003450.3.
    WP_003863342.1. NC_006958.1.

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3RH0X-ray1.72A/B1-129[»]
    ProteinModelPortaliP0DKS7.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi196627.cg0319.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblBacteriaiBAB97656; BAB97656; BAB97656.
    CAF18834; CAF18834; cg0319.
    GeneIDi1021323.
    KEGGicgb:cg0319.
    cgl:NCgl0259.

    Phylogenomic databases

    eggNOGiCOG0394. LUCA.
    KOiK18701.
    OMAiELRSCEY.

    Enzyme and pathway databases

    BRENDAi2.8.4.2. 960.

    Family and domain databases

    InterProiIPR023485. Ptyr_pPase_SF.
    [Graphical view]
    PfamiPF01451. LMWPc. 1 hit.
    [Graphical view]
    SMARTiSM00226. LMWPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52788. SSF52788. 1 hit.
    ProtoNetiSearch...

    Entry informationi

    Entry nameiARSC2_CORGL
    AccessioniPrimary (citable) accession number: P0DKS7
    Secondary accession number(s): Q6M898, Q8NTP3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2013
    Last sequence update: January 9, 2013
    Last modified: September 7, 2016
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.