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Protein

Alpha-conotoxin CnIJ

Gene
N/A
Organism
Conus consors (Singed cone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

Found in injectable (milked) (IV) venom.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionToxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin CnIJ
Cleaved into the following chain:
OrganismiConus consors (Singed cone)
Taxonomic identifieri101297 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000041987118 – 44Add BLAST27
PeptideiPRO_000041987245 – 59Alpha-conotoxin CnIJAdd BLAST15
PeptideiPRO_000041987347 – 59Alpha-conotoxin CnIEAdd BLAST13

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 52By similarity
Disulfide bondi48 ↔ 59By similarity
Modified residuei59Cysteine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha3/6 pattern.

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR009958. Conotoxin_a-typ.
PfamiView protein in Pfam
PF07365. Toxin_8. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DKP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFTVFLLVV LTTTVVSFPS DSASDGRDDE AKDERSDMYE LKRNGRCCHP
60
ACGGKYFKCG R
Length:61
Mass (Da):6,843
Last modified:October 31, 2012 - v1
Checksum:i2A76EF20C68DAF5E
GO

Mass spectrometryi

Molecular mass is 1623.66 Da from positions 45 - 59. Determined by ESI. CnIJ.1 Publication
Molecular mass is 1410.56 Da from positions 47 - 59. Determined by ESI. CnIE.1 Publication

Similar proteinsi

Entry informationi

Entry nameiCA1E_CONCN
AccessioniPrimary (citable) accession number: P0DKP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2012
Last sequence update: October 31, 2012
Last modified: November 22, 2017
This is version 10 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families