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Protein

Conotoxin fe11.1

Gene
N/A
Organism
Conus ferrugineus (Cone snail)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin fe11.1
OrganismiConus ferrugineus (Cone snail)
Taxonomic identifieri379542 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000041983226 – 58Conotoxin fe11.1Add BLAST33
PropeptideiPRO_000041983362 – 74By similarityAdd BLAST13

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 42By similarity
Disulfide bondi35 ↔ 47By similarity
Disulfide bondi41 ↔ 51By similarity
Disulfide bondi46 ↔ 55By similarity
Modified residuei58Proline amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiP0DKM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I2 superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR013141. Conotoxin-I_CS.
IPR020242. Conotoxin_I2-superfamily.
PfamiView protein in Pfam
PF17557. Conotoxin_I2. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD267162. Conotoxin_I2-superfamily. 1 hit.
PROSITEiView protein in PROSITE
PS60019. I_CONOTOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DKM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFRVTSVGC FLLVIVLLHV AAVTSDDCRP EAAYCEYNEQ CCIDKCCQAS
60 70
CSDACRTPGK RVHGHGLLRF FGQR
Length:74
Mass (Da):8,232
Last modified:October 31, 2012 - v1
Checksum:i8FE7FB37A01A6C75
GO

Similar proteinsi

Entry informationi

Entry nameiCI2B1_CONFR
AccessioniPrimary (citable) accession number: P0DKM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2012
Last sequence update: October 31, 2012
Last modified: November 22, 2017
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Caution

This sequence has been copied from a figure, and no information except the name are available for it. The species, and the sequence origin are only deduced to be C.ferrugineus and nucleotide sequence.Curated

Documents

  1. SIMILARITY comments
    Index of protein domains and families