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P0DJX8 (ALT2B_ENMGO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 24, 2013. Version 1. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Protein attributes

Sequence length129 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Disruption phenotype

Knockout mutants display an attenuated small-plaque phenotype. Ref.2

Sequence similarities

Belongs to the encephalomyocarditis virus protein 2B* family.

Ontologies

Keywords
   Coding sequence diversityRibosomal frameshifting
   Technical termComplete proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by ribosomal frameshifting. [Align] [Select]
Isoform 2B* (identifier: P0DJX8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Produced by -1 ribosomal frameshifting.
Isoform Genome polyprotein (identifier: P12296-1)

The sequence of this isoform can be found in the external entry P12296.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by conventional translation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 129129Protein 2B*
PRO_0000423151

Sequences

Sequence LengthMass (Da)Tools
Isoform 2B* [UniParc].

Last modified July 24, 2013. Version 1.
Checksum: 5998E60AF0C8FB98

FASTA12914,191
        10         20         30         40         50         60 
PFTFKPRQRP VFSDSRSGSV INGSNPTAER LGQQSYGISL YGFARCQRGR PKSNEDYKDV 

        70         80         90        100        110        120 
KFSIGCMGKC KRNIEQPGVL ETTLKQMCAT DCRDDDSSDA SGPLDAALLG SLDSSRDHKP 


DKPVRRNSS 

« Hide

Isoform Genome polyprotein [UniParc].

See P12296.

References

[1]"Dipyridamole reversibly inhibits mengovirus RNA replication."
Fata-Hartley C.L., Palmenberg A.C.
J. Virol. 79:11062-11070(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Medium plague.
[2]"Ribosomal frameshifting into an overlapping gene in the 2B-encoding region of the cardiovirus genome."
Loughran G., Firth A.E., Atkins J.F.
Proc. Natl. Acad. Sci. U.S.A. 108:E1111-E1119(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, RIBOSOMAL FRAMESHIFTING, DISRUPTION PHENOTYPE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ294633 Genomic RNA. No translation available.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameALT2B_ENMGO
AccessionPrimary (citable) accession number: P0DJX8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2013
Last sequence update: July 24, 2013
Last modified: July 24, 2013
This is version 1 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families