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P0DJX8

- ALT2B_ENMGO

UniProt

P0DJX8 - ALT2B_ENMGO

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Protein
Protein 2B*
Gene
N/A
Organism
Mengo encephalomyocarditis virus
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein 2B*
OrganismiMengo encephalomyocarditis virus
Taxonomic identifieri12107 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stagePicornaviralesPicornaviridaeCardiovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Mus musculus (Mouse) [TaxID: 10090]
Oryctolagus cuniculus (Rabbit) [TaxID: 9986]
ProteomesiUP000008663: Genome

Pathology & Biotechi

Disruption phenotypei

Knockout mutants display an attenuated small-plaque phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 129129Protein 2B*
PRO_0000423151Add
BLAST

Family & Domainsi

Sequence similaritiesi

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by ribosomal frameshifting. Align

Isoform 2B* (identifier: P0DJX8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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PFTFKPRQRP VFSDSRSGSV INGSNPTAER LGQQSYGISL YGFARCQRGR    50
PKSNEDYKDV KFSIGCMGKC KRNIEQPGVL ETTLKQMCAT DCRDDDSSDA 100
SGPLDAALLG SLDSSRDHKP DKPVRRNSS 129

Note: Produced by -1 ribosomal frameshifting.

Length:129
Mass (Da):14,191
Last modified:July 24, 2013 - v1
Checksum:i5998E60AF0C8FB98
GO
Isoform Genome polyprotein (identifier: P12296-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry P12296.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by conventional translation.

Length:2,293
Mass (Da):255,528
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ294633 Genomic RNA. No translation available.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ294633 Genomic RNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Dipyridamole reversibly inhibits mengovirus RNA replication."
    Fata-Hartley C.L., Palmenberg A.C.
    J. Virol. 79:11062-11070(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Medium plague.
  2. "Ribosomal frameshifting into an overlapping gene in the 2B-encoding region of the cardiovirus genome."
    Loughran G., Firth A.E., Atkins J.F.
    Proc. Natl. Acad. Sci. U.S.A. 108:E1111-E1119(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, RIBOSOMAL FRAMESHIFTING, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiALT2B_ENMGO
AccessioniPrimary (citable) accession number: P0DJX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2013
Last sequence update: July 24, 2013
Last modified: July 24, 2013
This is version 1 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3