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Protein

Protein 2B*

Gene
N/A
Organism
Mengo encephalomyocarditis virus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein 2B*
OrganismiMengo encephalomyocarditis virus
Taxonomic identifieri12107 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stagePicornaviralesPicornaviridaeCardiovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Mus musculus (Mouse) [TaxID: 10090]
Oryctolagus cuniculus (Rabbit) [TaxID: 9986]
ProteomesiUP000008663: Genome

Pathology & Biotechi

Disruption phenotypei

Knockout mutants display an attenuated small-plaque phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 129129Protein 2B*PRO_0000423151Add
BLAST

Family & Domainsi

Sequence similaritiesi

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by ribosomal frameshifting. AlignAdd to basket

Isoform 2B* (identifier: P0DJX8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
PFTFKPRQRP VFSDSRSGSV INGSNPTAER LGQQSYGISL YGFARCQRGR
60 70 80 90 100
PKSNEDYKDV KFSIGCMGKC KRNIEQPGVL ETTLKQMCAT DCRDDDSSDA
110 120
SGPLDAALLG SLDSSRDHKP DKPVRRNSS

Note: Produced by -1 ribosomal frameshifting.

Length:129
Mass (Da):14,191
Last modified:July 24, 2013 - v1
Checksum:i5998E60AF0C8FB98
GO
Isoform Genome polyprotein (identifier: P12296-1) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry P12296.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by conventional translation.

Length:2,293
Mass (Da):255,528
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ294633 Genomic RNA. No translation available.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ294633 Genomic RNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Dipyridamole reversibly inhibits mengovirus RNA replication."
    Fata-Hartley C.L., Palmenberg A.C.
    J. Virol. 79:11062-11070(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Medium plague.
  2. "Ribosomal frameshifting into an overlapping gene in the 2B-encoding region of the cardiovirus genome."
    Loughran G., Firth A.E., Atkins J.F.
    Proc. Natl. Acad. Sci. U.S.A. 108:E1111-E1119(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, RIBOSOMAL FRAMESHIFTING, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiALT2B_ENMGO
AccessioniPrimary (citable) accession number: P0DJX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2013
Last sequence update: July 24, 2013
Last modified: January 7, 2015
This is version 3 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.