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P0DJX8

- ALT2B_ENMGO

UniProt

P0DJX8 - ALT2B_ENMGO

Protein

Protein 2B*

Gene
N/A
Organism
Mengo encephalomyocarditis virus
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein 2B*
    OrganismiMengo encephalomyocarditis virus
    Taxonomic identifieri12107 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stagePicornaviralesPicornaviridaeCardiovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Mus musculus (Mouse) [TaxID: 10090]
    Oryctolagus cuniculus (Rabbit) [TaxID: 9986]
    ProteomesiUP000008663: Genome

    Pathology & Biotechi

    Disruption phenotypei

    Knockout mutants display an attenuated small-plaque phenotype.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 129129Protein 2B*PRO_0000423151Add
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by ribosomal frameshifting. Align

    Isoform 2B* (identifier: P0DJX8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    PFTFKPRQRP VFSDSRSGSV INGSNPTAER LGQQSYGISL YGFARCQRGR    50
    PKSNEDYKDV KFSIGCMGKC KRNIEQPGVL ETTLKQMCAT DCRDDDSSDA 100
    SGPLDAALLG SLDSSRDHKP DKPVRRNSS 129

    Note: Produced by -1 ribosomal frameshifting.

    Length:129
    Mass (Da):14,191
    Last modified:July 24, 2013 - v1
    Checksum:i5998E60AF0C8FB98
    GO
    Isoform Genome polyprotein (identifier: P12296-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry P12296.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: Produced by conventional translation.

    Length:2,293
    Mass (Da):255,528
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ294633 Genomic RNA. No translation available.

    Keywords - Coding sequence diversityi

    Ribosomal frameshifting

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ294633 Genomic RNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Dipyridamole reversibly inhibits mengovirus RNA replication."
      Fata-Hartley C.L., Palmenberg A.C.
      J. Virol. 79:11062-11070(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Medium plague.
    2. "Ribosomal frameshifting into an overlapping gene in the 2B-encoding region of the cardiovirus genome."
      Loughran G., Firth A.E., Atkins J.F.
      Proc. Natl. Acad. Sci. U.S.A. 108:E1111-E1119(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, RIBOSOMAL FRAMESHIFTING, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiALT2B_ENMGO
    AccessioniPrimary (citable) accession number: P0DJX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2013
    Last sequence update: July 24, 2013
    Last modified: October 1, 2014
    This is version 2 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3