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Protein

Zinc metalloproteinase-disintegrin-like alborhagin

Gene
N/A
Organism
Trimeresurus albolabris (White-lipped pit viper) (Cryptelytrops albolabris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Zinc metalloproteinase-disintegrin-like alborhagin: induces platelet activation and glycoprotein VI (GP6)-dependent platelet aggregation. Induces ectodomain cleavage of GP6 by activating endogenous platelet metalloproteinases (probably ADAM10). Has fibrinogenolytic activity against the alpha chain of fibrinogen (FGA). Recognizes distinct binding sites as convulxin, since alborhagin has minimal effect on convulxin binding to GPVI-expressing cells.1 Publication
Disintegrin alborhagin-C: 42 kDa fragment of alborhagin autoproteolysed that does not show platelet activation.1 Publication

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Enzyme regulationi

Alborhagin-induced platelet aggregation, but not shape change, is inhibited by EDTA, suggesting that the platelet activation (shape change) is independent of divalent cation or metalloproteinase activity.

GO - Molecular functioni

Keywordsi

Molecular functionCell adhesion impairing toxin, Fibrinogenolytic toxin, Hemostasis impairing toxin, Hydrolase, Metalloprotease, Platelet aggregation activating toxin, Protease, Toxin
LigandCalcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase-disintegrin-like alborhagin (EC:3.4.24.-)
Alternative name(s):
Snake venom metalloproteinase
Short name:
SVMP
Cleaved into the following chain:
OrganismiTrimeresurus albolabris (White-lipped pit viper) (Cryptelytrops albolabris)
Taxonomic identifieri8765 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeTrimeresurus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000417321‹1 – ›53Zinc metalloproteinase-disintegrin-like alborhaginAdd BLAST›53
ChainiPRO_000041732237 – ›53Disintegrin-like alborhagin-CAdd BLAST›17

Post-translational modificationi

Contains numerous disulfide bonds.By similarity
Glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer.

Family & Domainsi

Sequence similaritiesi

Sequencei

Sequence statusi: Fragments.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DJH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RYIPYDQEDV KRQMVAAIGI EDKNTVTRAN YYTLDLXIDT VTPDVNRNEL

KEK
Length:53
Mass (Da):6,228
Last modified:May 16, 2012 - v1
Checksum:i2DF0ACC7D2852FEA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence uncertaintyi1Assigned by comparison with orthologs1
Non-terminal residuei11
Non-adjacent residuesi11 – 12Curated2
Sequence uncertaintyi12R or K1
Sequence uncertaintyi21Assigned by comparison with orthologs1
Non-adjacent residuesi22 – 23Curated2
Sequence uncertaintyi23Assigned by comparison with orthologs1
Non-adjacent residuesi36 – 37Curated2
Non-terminal residuei531

Entry informationi

Entry nameiVM3AL_TRIAB
AccessioniPrimary (citable) accession number: P0DJH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2012
Last sequence update: May 16, 2012
Last modified: February 15, 2017
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families