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Protein

Apolipoprotein A-I

Gene

APOA1

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein A-I
Short name:
Apo-AI
Short name:
ApoA-I
Alternative name(s):
Apolipoprotein A1
Cleaved into the following 2 chains:
Gene namesi
Name:APOA1
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 267249Proapolipoprotein A-IPRO_0000425330Add
BLAST
Chaini25 – 267243Apolipoprotein A-IPRO_0000416563Add
BLAST
Chaini25 – 266242Truncated apolipoprotein A-IPRO_0000416564Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei110 – 1101Methionine sulfoxideBy similarity
Modified residuei136 – 1361Methionine sulfoxideBy similarity

Post-translational modificationi

Glycosylated.By similarity
Palmitoylated.By similarity
Phosphorylation sites are present in the extracellular medium.By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Oxidation, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP0DJG0.
PRIDEiP0DJG0.

Expressioni

Tissue specificityi

Major protein of plasma HDL, also found in chylomicrons.

Interactioni

Subunit structurei

Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000007404.

Structurei

3D structure databases

ProteinModelPortaliP0DJG0.
SMRiP0DJG0. Positions 26-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati68 – 89221Add
BLAST
Repeati90 – 111222Add
BLAST
Repeati112 – 122113; half-lengthAdd
BLAST
Repeati123 – 144224Add
BLAST
Repeati145 – 166225Add
BLAST
Repeati167 – 188226Add
BLAST
Repeati189 – 210227Add
BLAST
Repeati211 – 232228Add
BLAST
Repeati233 – 243119; half-lengthAdd
BLAST
Repeati244 – 2672410Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni68 – 26720010 X approximate tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IWKR. Eukaryota.
ENOG410YGQ6. LUCA.
GeneTreeiENSGT00530000063081.
InParanoidiP0DJG0.
KOiK08757.
OMAiKDFATVY.
OrthoDBiEOG7TBC3N.
TreeFamiTF334458.

Family and domain databases

InterProiIPR000074. ApoA_E.
[Graphical view]
PfamiPF01442. Apolipoprotein. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DJG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAAVLTLAV LFLTGSQARH FWQQDEPPQS PWDRVKDLAT VYVDVLKDSG
60 70 80 90 100
RDYVSQFEGS ALGKQLNLKL LDNWDSVTST FSKLREQLGP VTQEFWDNLE
110 120 130 140 150
KETEGLRQEM SKDLEEVKAK VQPYLDDFQK KWQEEMELYR QKVEPLRAEL
160 170 180 190 200
QEGARQKLHE LQEKLSPLGE EMRDRARAHV DALRTHLAPY SDELRQRLAA
210 220 230 240 250
RLEALKENGG ARLAEYHAKA TEHLSTLSEK AKPALEDLRQ GLLPVLESFK
260
VSFLSALEEY TKKLNTQ
Length:267
Mass (Da):30,778
Last modified:April 18, 2012 - v1
Checksum:i1A28B8366E620310
GO

Mass spectrometryi

Molecular mass is 28079.33±1.258 Da from positions 25 - 267. Determined by ESI. 1 Publication
Molecular mass is 27953.3 Da from positions 25 - 266. Determined by ESI. 1 Publication

Sequence databases

RefSeqiXP_001153383.1. XM_001153383.4.
XP_001153517.1. XM_001153517.4.
XP_508770.1. XM_508770.5.

Genome annotation databases

EnsembliENSPTRT00000008023; ENSPTRP00000007404; ENSPTRG00000004316.
GeneIDi451564.
KEGGiptr:451564.

Cross-referencesi

Sequence databases

RefSeqiXP_001153383.1. XM_001153383.4.
XP_001153517.1. XM_001153517.4.
XP_508770.1. XM_508770.5.

3D structure databases

ProteinModelPortaliP0DJG0.
SMRiP0DJG0. Positions 26-267.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000007404.

Proteomic databases

PaxDbiP0DJG0.
PRIDEiP0DJG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000008023; ENSPTRP00000007404; ENSPTRG00000004316.
GeneIDi451564.
KEGGiptr:451564.

Organism-specific databases

CTDi335.

Phylogenomic databases

eggNOGiENOG410IWKR. Eukaryota.
ENOG410YGQ6. LUCA.
GeneTreeiENSGT00530000063081.
InParanoidiP0DJG0.
KOiK08757.
OMAiKDFATVY.
OrthoDBiEOG7TBC3N.
TreeFamiTF334458.

Family and domain databases

InterProiIPR000074. ApoA_E.
[Graphical view]
PfamiPF01442. Apolipoprotein. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mass spectral analyses of the two major apolipoproteins of great ape high density lipoproteins."
    Puppione D.L., Della Donna L., Laganowsky A.D., Bassilian S., Souda P., Ryder O.A., Whitelegge J.P.
    Comp. Biochem. Physiol. 4:305-309(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiAPOA1_PANTR
AccessioniPrimary (citable) accession number: P0DJG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: April 18, 2012
Last modified: May 11, 2016
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.