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P0DJF9

- MTAP_SYNYG

UniProt

P0DJF9 - MTAP_SYNYG

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Protein
S-methyl-5'-thioadenosine phosphorylase
Gene
mtnP, SYNGTS_1998
Organism
Synechocystis sp. (strain PCC 6803 / GT-S)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates By similarity.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441Phosphate By similarity
Sitei202 – 2021Important for substrate specificity By similarity
Binding sitei220 – 2201Substrate; via amide nitrogen By similarity
Binding sitei221 – 2211Phosphate By similarity
Sitei257 – 2571Important for substrate specificity By similarity

GO - Molecular functioni

  1. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP
  2. phosphorylase activity Source: InterPro

GO - Biological processi

  1. L-methionine salvage from methylthioadenosine Source: UniProtKB-HAMAP
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciSSP1148:GJOT-2026-MONOMER.
UniPathwayiUPA00904; UER00873.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylase (EC:2.4.2.28)
Alternative name(s):
5'-methylthioadenosine phosphorylase
Short name:
MTA phosphorylase
Short name:
MTAP
Gene namesi
Name:mtnP
Ordered Locus Names:SYNGTS_1998
OrganismiSynechocystis sp. (strain PCC 6803 / GT-S)
Taxonomic identifieri1111707 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000008187: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326S-methyl-5'-thioadenosine phosphorylaseUniRule annotation
PRO_0000416437Add
BLAST

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP0DJF9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni86 – 872Phosphate binding By similarity
Regioni119 – 1202Phosphate binding By similarity
Regioni244 – 2463Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

KOiK00772.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01694. MTAP. 1 hit.

Sequencei

Sequence statusi: Complete.

P0DJF9-1 [UniParc]FASTAAdd to Basket

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MGMIISMAMT AVTIWTKTKP GRVSCFIRKN STMVNAPIGI IGGSGLYQME    50
ALKNVEEVTL DTPFGAPSDS FIVGELAGVR VAFLARHGRG HHLLPSEIPF 100
RANIHGMKQL GVKYLISASA VGSLQAEAKP LDMVVPDQFI DRTRQRISTF 150
FGEGIVAHIG FGNPICPQLA QCLSTAIAGL ELEGVTLHDR GTYVSMEGPA 200
FSTIAESNLY RSWGGTVIGM TNLPEAKLAR EAEIAYATLA LVTDYDCWHP 250
DHDHVTVEMV IGNLQKNAVN AQQVILETVK QLAANPFESI AHRALQYAVL 300
TPPDKFPAAT YEKLSLLLGK YYPPAP 326
Length:326
Mass (Da):35,319
Last modified:March 21, 2012 - v1
Checksum:i06F7D98E67A7BCD8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012205 Genomic DNA. Translation: BAK50746.1.
RefSeqiNP_441892.1. NC_000911.1.
YP_005651951.1. NC_017277.1.
YP_007451772.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAK50746; BAK50746; SYNGTS_1998.
GeneIDi952850.
KEGGisyn:sll0135.
syy:SYNGTS_1998.
syz:MYO_120170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012205 Genomic DNA. Translation: BAK50746.1 .
RefSeqi NP_441892.1. NC_000911.1.
YP_005651951.1. NC_017277.1.
YP_007451772.1. NC_020286.1.

3D structure databases

ProteinModelPortali P0DJF9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAK50746 ; BAK50746 ; SYNGTS_1998 .
GeneIDi 952850.
KEGGi syn:sll0135.
syy:SYNGTS_1998.
syz:MYO_120170.

Phylogenomic databases

KOi K00772.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00873 .
BioCyci SSP1148:GJOT-2026-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01694. MTAP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomic structure of the cyanobacterium Synechocystis sp. PCC 6803 strain GT-S."
    Tajima N., Sato S., Maruyama F., Kaneko T., Sasaki N.V., Kurokawa K., Ohta H., Kanesaki Y., Yoshikawa H., Tabata S., Ikeuchi M., Sato N.
    DNA Res. 18:393-399(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / GT-S.

Entry informationi

Entry nameiMTAP_SYNYG
AccessioniPrimary (citable) accession number: P0DJF9
Secondary accession number(s): P74469
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: March 21, 2012
Last modified: July 9, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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