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P0DJF8

- MTAP_SYNY3

UniProt

P0DJF8 - MTAP_SYNY3

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Protein

S-methyl-5'-thioadenosine phosphorylase

Gene
mtnP, sll0135
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates By similarity.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441Phosphate By similarity
Sitei202 – 2021Important for substrate specificity By similarity
Binding sitei220 – 2201Substrate; via amide nitrogen By similarity
Binding sitei221 – 2211Phosphate By similarity
Sitei257 – 2571Important for substrate specificity By similarity

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-methionine salvage from methylthioadenosine Source: UniProtKB-HAMAP
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

UniPathwayiUPA00904; UER00873.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylase (EC:2.4.2.28)
Alternative name(s):
5'-methylthioadenosine phosphorylase
Short name:
MTA phosphorylase
Short name:
MTAP
Gene namesi
Name:mtnP
Ordered Locus Names:sll0135
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326S-methyl-5'-thioadenosine phosphorylaseUniRule annotationPRO_0000415100Add
BLAST

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer By similarity.UniRule annotation

Protein-protein interaction databases

IntActiP0DJF8. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP0DJF8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni86 – 872Phosphate binding By similarity
Regioni119 – 1202Phosphate binding By similarity
Regioni244 – 2463Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

KOiK00772.
OMAiCEAQLCY.
OrthoDBiEOG6KHFXC.
PhylomeDBiP0DJF8.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01694. MTAP. 1 hit.

Sequencei

Sequence statusi: Complete.

P0DJF8-1 [UniParc]FASTAAdd to Basket

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MGMIISMAMT AVTIWTKTKP GRVSCFIRKN STMVNAPIGI IGGSGLYQME    50
ALKNVEEVTL DTPFGAPSDS FIVGELAGVR VAFLARHGRG HHLLPSEIPF 100
RANIHGMKQL GVKYLISASA VGSLQAEAKP LDMVVPDQFI DRTRQRISTF 150
FGEGIVAHIG FGNPICPQLA QCLSTAIAGL ELEGVTLHDR GTYVSMEGPA 200
FSTIAESNLY RSWGGTVIGM TNLPEAKLAR EAEIAYATLA LVTDYDCWHP 250
DHDHVTVEMV IGNLQKNAVN AQQVILETVK QLAANPFESI AHRALQYAVL 300
TPPDKFPAAT YEKLSLLLGK YYPPAP 326
Length:326
Mass (Da):35,319
Last modified:March 21, 2012 - v1
Checksum:i06F7D98E67A7BCD8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA18570.1.
PIRiS76441.
RefSeqiNP_441892.1. NC_000911.1.
YP_005651951.1. NC_017277.1.
YP_007451772.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18570; BAA18570; BAA18570.
GeneIDi952850.
KEGGisyn:sll0135.
syy:SYNGTS_1998.
syz:MYO_120170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA18570.1 .
PIRi S76441.
RefSeqi NP_441892.1. NC_000911.1.
YP_005651951.1. NC_017277.1.
YP_007451772.1. NC_020286.1.

3D structure databases

ProteinModelPortali P0DJF8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P0DJF8. 1 interaction.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA18570 ; BAA18570 ; BAA18570 .
GeneIDi 952850.
KEGGi syn:sll0135.
syy:SYNGTS_1998.
syz:MYO_120170.

Phylogenomic databases

KOi K00772.
OMAi CEAQLCY.
OrthoDBi EOG6KHFXC.
PhylomeDBi P0DJF8.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00873 .

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01694. MTAP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiMTAP_SYNY3
AccessioniPrimary (citable) accession number: P0DJF8
Secondary accession number(s): P74469
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: March 21, 2012
Last modified: July 9, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

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