P0DJD4 (RBY1C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA-binding motif protein, Y chromosome, family 1 member C

Gene names

Name:

RBMY1C

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	496 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.
Subunit structure	Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3. Ref.3 Ref.4 Ref.5
Subcellular location	Nucleus Ref.2.
Tissue specificity	Testis-specific.
Developmental stage	Expressed in all of the transcriptionally active stages of germ cell development from spermatogonia through spermatocytes to round spermatids. Ref.2
Miscellaneous	The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.
Sequence similarities	Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus
Ligand	RNA-binding
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 496	496	RNA-binding motif protein, Y chromosome, family 1 member C		PRO_0000415665
Regions
	Domain	8 – 85	78	RRM
	Compositional bias	254 – 340	87	Arg-rich

Sequences

	Sequence		Length	Mass (Da)
	P0DJD4 [UniParc]. Last modified February 22, 2012. Version 1. Checksum: F912A0248CE0282E	FASTA	496	55,784
	10 20 30 40 50 60 MVEADHPGKL FIGGLNRETN EKMLKAVFGK HGPISEVLLI KDRTSKSRGF AFITFENPAD 70 80 90 100 110 120 AKNAAKDMNG KSLHGKAIKV EQAQKPSFQS GGRRRPPASS RNRSPSGSLR SARGSRGGTR 130 140 150 160 170 180 GWLPSHEGHL DDGGYTPDLK MSYSRGLIPV KRGPSSRSGG PPPKKSAPSA VARSNSWMGS 190 200 210 220 230 240 QGPMSQRREN YGVPPRRATI SSWRNDRMST RHDGYATNDG NHPSCQETRD YAPPSRGYAY 250 260 270 280 290 300 RDNGHSNRDE HSSRGYRNHR SSRETRDYAP PSRGHAYRDY GHSRRDESYS RGYRNRRSSR 310 320 330 340 350 360 ETREYAPPSR GHGYRDYGHS RRHESYSRGY RNHPSSRETR DYAPPHRDYA YRDYGHSSWD 370 380 390 400 410 420 EHSSRGYSYH DGYGEALGRD HSEHLSGSSY RDALQRYGTS HGAPPARGPR MSYGGSTCHA 430 440 450 460 470 480 YSNTRDRYGR SWESYSSCGD FHYCDREHVC RKDQRNPPSL GRVLPDPREA CGSSSYVASI 490 VDGGESRSEK GDSSRY

References

[1]	"Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene." Chai N.-N., Zhou H., Hernandez J., Najmabadi H., Bhasin S., Yen P.H. Genomics 49:283-289(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-220 AND 332-496.
[2]	"Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm." Elliott D.J., Millar M.R., Oghene K., Ross A., Kiesewetter F., Pryor J., McIntyre M., Hargreave T.B., Saunders P.T.K., Vogt P.H., Chandley A.C., Cooke H. Proc. Natl. Acad. Sci. U.S.A. 94:3848-3853(1997) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
[3]	"T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis." Venables J.P., Vernet C., Chew S.L., Elliott D.J., Cowmeadow R.B., Wu J., Cooke H.J., Artzt K., Eperon I.C. Hum. Mol. Genet. 8:959-969(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH KHDRBS3.
[4]	"RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing." Venables J.P., Elliott D.J., Makarova O.V., Makarov E.M., Cooke H.J., Eperon E.C. Hum. Mol. Genet. 9:685-694(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TRA2B. Tissue: Testis.
[5]	"The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis." Elliott D.J. Int. J. Androl. 27:328-334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH KHDRBS1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U36608 , U36604, U36605, U36606, U36607 Genomic DNA. Translation: AAC16917.1. U36610, U36609 Genomic DNA. Translation: AAC16918.1.
IPI	IPI00332760. IPI00872545. IPI00872656.
PIR	A49418.
3D structure databases
ProteinModelPortal	P0DJD4.
SMR	P0DJD4. Positions 1-108.
ModBase	Search...
Polymorphism databases
DMDM	27805716.
Proteomic databases
PRIDE	P0DJD4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC0YU900014.
HGNC	HGNC:9914. RBMY1C.
HPA	HPA001534.
MIM	400006. gene.
neXtProt	NX_P0DJD4.
GenAtlas	Search...
Gene expression databases
CleanEx	HS_RBMY1A1.
GermOnline	ENSG00000174622. Homo sapiens.
Family and domain databases
Gene3D	3.30.70.330. 1 hit.
InterPro	IPR012677. Nucleotide-bd_a/b_plait. IPR012604. RBM1CTR. IPR000504. RRM_dom. [Graphical view]
Pfam	PF08081. RBM1CTR. 1 hit. PF00076. RRM_1. 1 hit. [Graphical view]
SMART	SM00360. RRM. 1 hit. [Graphical view]
PROSITE	PS50102. RRM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

RBY1C_HUMAN

Accession

Primary (citable) accession number: P0DJD4
Secondary accession number(s): Q15376 , Q15377, Q15414, Q6NSB5, Q86VU6, Q8NHR0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 22, 2012
Last sequence update:	February 22, 2012
Last modified:	April 3, 2013
This is version 8 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.