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P0DJD4

- RBY1C_HUMAN

UniProt

P0DJD4 - RBY1C_HUMAN

Protein

RNA-binding motif protein, Y chromosome, family 1 member C

Gene

RBMY1C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 13 (01 Oct 2014)
      Sequence version 1 (22 Feb 2012)
      Previous versions | rss
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    Functioni

    RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. RNA splicing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-binding motif protein, Y chromosome, family 1 member C
    Gene namesi
    Name:RBMY1C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:9914. RBMY1C.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 496496RNA-binding motif protein, Y chromosome, family 1 member CPRO_0000415665Add
    BLAST

    Proteomic databases

    PRIDEiP0DJD4.

    Expressioni

    Tissue specificityi

    Testis-specific.

    Developmental stagei

    Expressed in all of the transcriptionally active stages of germ cell development from spermatogonia through spermatocytes to round spermatids.1 Publication

    Gene expression databases

    CleanExiHS_RBMY1A1.

    Organism-specific databases

    HPAiHPA001534.

    Interactioni

    Subunit structurei

    Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3.3 Publications

    Structurei

    3D structure databases

    ProteinModelPortaliP0DJD4.
    SMRiP0DJD4. Positions 1-108.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 8578RRMPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi254 – 34087Arg-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR012604. RBM1CTR.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF08081. RBM1CTR. 1 hit.
    PF00076. RRM_1. 1 hit.
    [Graphical view]
    SMARTiSM00360. RRM. 1 hit.
    [Graphical view]
    PROSITEiPS50102. RRM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0DJD4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVEADHPGKL FIGGLNRETN EKMLKAVFGK HGPISEVLLI KDRTSKSRGF    50
    AFITFENPAD AKNAAKDMNG KSLHGKAIKV EQAQKPSFQS GGRRRPPASS 100
    RNRSPSGSLR SARGSRGGTR GWLPSHEGHL DDGGYTPDLK MSYSRGLIPV 150
    KRGPSSRSGG PPPKKSAPSA VARSNSWMGS QGPMSQRREN YGVPPRRATI 200
    SSWRNDRMST RHDGYATNDG NHPSCQETRD YAPPSRGYAY RDNGHSNRDE 250
    HSSRGYRNHR SSRETRDYAP PSRGHAYRDY GHSRRDESYS RGYRNRRSSR 300
    ETREYAPPSR GHGYRDYGHS RRHESYSRGY RNHPSSRETR DYAPPHRDYA 350
    YRDYGHSSWD EHSSRGYSYH DGYGEALGRD HSEHLSGSSY RDALQRYGTS 400
    HGAPPARGPR MSYGGSTCHA YSNTRDRYGR SWESYSSCGD FHYCDREHVC 450
    RKDQRNPPSL GRVLPDPREA CGSSSYVASI VDGGESRSEK GDSSRY 496
    Length:496
    Mass (Da):55,784
    Last modified:February 22, 2012 - v1
    Checksum:iF912A0248CE0282E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U36608
    , U36604, U36605, U36606, U36607 Genomic DNA. Translation: AAC16917.1.
    U36610, U36609 Genomic DNA. Translation: AAC16918.1.
    PIRiA49418.

    Polymorphism databases

    DMDMi378522970.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U36608
    , U36604 , U36605 , U36606 , U36607 Genomic DNA. Translation: AAC16917.1 .
    U36610 , U36609 Genomic DNA. Translation: AAC16918.1 .
    PIRi A49418.

    3D structure databases

    ProteinModelPortali P0DJD4.
    SMRi P0DJD4. Positions 1-108.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 378522970.

    Proteomic databases

    PRIDEi P0DJD4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC0YU900014.
    HGNCi HGNC:9914. RBMY1C.
    HPAi HPA001534.
    MIMi 400006. gene.
    neXtProti NX_P0DJD4.
    GenAtlasi Search...

    Miscellaneous databases

    PROi P0DJD4.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_RBMY1A1.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR012604. RBM1CTR.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF08081. RBM1CTR. 1 hit.
    PF00076. RRM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00360. RRM. 1 hit.
    [Graphical view ]
    PROSITEi PS50102. RRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene."
      Chai N.-N., Zhou H., Hernandez J., Najmabadi H., Bhasin S., Yen P.H.
      Genomics 49:283-289(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-220 AND 332-496.
    2. "Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm."
      Elliott D.J., Millar M.R., Oghene K., Ross A., Kiesewetter F., Pryor J., McIntyre M., Hargreave T.B., Saunders P.T.K., Vogt P.H., Chandley A.C., Cooke H.
      Proc. Natl. Acad. Sci. U.S.A. 94:3848-3853(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
    3. "T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis."
      Venables J.P., Vernet C., Chew S.L., Elliott D.J., Cowmeadow R.B., Wu J., Cooke H.J., Artzt K., Eperon I.C.
      Hum. Mol. Genet. 8:959-969(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KHDRBS3.
    4. "RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing."
      Venables J.P., Elliott D.J., Makarova O.V., Makarov E.M., Cooke H.J., Eperon E.C.
      Hum. Mol. Genet. 9:685-694(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRA2B.
      Tissue: Testis.
    5. "The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis."
      Elliott D.J.
      Int. J. Androl. 27:328-334(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KHDRBS1.

    Entry informationi

    Entry nameiRBY1C_HUMAN
    AccessioniPrimary (citable) accession number: P0DJD4
    Secondary accession number(s): Q15376
    , Q15377, Q15414, Q6NSB5, Q86VU6, Q8NHR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 22, 2012
    Last sequence update: February 22, 2012
    Last modified: October 1, 2014
    This is version 13 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome Y
      Human chromosome Y: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3