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P0DJD4 (RBY1C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA-binding motif protein, Y chromosome, family 1 member C
Gene names
Name:RBMY1C
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length496 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.

Subunit structure

Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3. Ref.3 Ref.4 Ref.5

Subcellular location

Nucleus Ref.2.

Tissue specificity

Testis-specific.

Developmental stage

Expressed in all of the transcriptionally active stages of germ cell development from spermatogonia through spermatocytes to round spermatids. Ref.2

Miscellaneous

The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.

Sequence similarities

Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
   Biological processmRNA processing
mRNA splicing
   Cellular componentNucleus
   LigandRNA-binding
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRNA splicing

Inferred from electronic annotation. Source: UniProtKB-KW

mRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 496496RNA-binding motif protein, Y chromosome, family 1 member C
PRO_0000415665

Regions

Domain8 – 8578RRM
Compositional bias254 – 34087Arg-rich

Sequences

Sequence LengthMass (Da)Tools
P0DJD4 [UniParc].

Last modified February 22, 2012. Version 1.
Checksum: F912A0248CE0282E

FASTA49655,784
        10         20         30         40         50         60 
MVEADHPGKL FIGGLNRETN EKMLKAVFGK HGPISEVLLI KDRTSKSRGF AFITFENPAD 

        70         80         90        100        110        120 
AKNAAKDMNG KSLHGKAIKV EQAQKPSFQS GGRRRPPASS RNRSPSGSLR SARGSRGGTR 

       130        140        150        160        170        180 
GWLPSHEGHL DDGGYTPDLK MSYSRGLIPV KRGPSSRSGG PPPKKSAPSA VARSNSWMGS 

       190        200        210        220        230        240 
QGPMSQRREN YGVPPRRATI SSWRNDRMST RHDGYATNDG NHPSCQETRD YAPPSRGYAY 

       250        260        270        280        290        300 
RDNGHSNRDE HSSRGYRNHR SSRETRDYAP PSRGHAYRDY GHSRRDESYS RGYRNRRSSR 

       310        320        330        340        350        360 
ETREYAPPSR GHGYRDYGHS RRHESYSRGY RNHPSSRETR DYAPPHRDYA YRDYGHSSWD 

       370        380        390        400        410        420 
EHSSRGYSYH DGYGEALGRD HSEHLSGSSY RDALQRYGTS HGAPPARGPR MSYGGSTCHA 

       430        440        450        460        470        480 
YSNTRDRYGR SWESYSSCGD FHYCDREHVC RKDQRNPPSL GRVLPDPREA CGSSSYVASI 

       490 
VDGGESRSEK GDSSRY 

« Hide

References

[1]"Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene."
Chai N.-N., Zhou H., Hernandez J., Najmabadi H., Bhasin S., Yen P.H.
Genomics 49:283-289(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-220 AND 332-496.
[2]"Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm."
Elliott D.J., Millar M.R., Oghene K., Ross A., Kiesewetter F., Pryor J., McIntyre M., Hargreave T.B., Saunders P.T.K., Vogt P.H., Chandley A.C., Cooke H.
Proc. Natl. Acad. Sci. U.S.A. 94:3848-3853(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
[3]"T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis."
Venables J.P., Vernet C., Chew S.L., Elliott D.J., Cowmeadow R.B., Wu J., Cooke H.J., Artzt K., Eperon I.C.
Hum. Mol. Genet. 8:959-969(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH KHDRBS3.
[4]"RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing."
Venables J.P., Elliott D.J., Makarova O.V., Makarov E.M., Cooke H.J., Eperon E.C.
Hum. Mol. Genet. 9:685-694(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TRA2B.
Tissue: Testis.
[5]"The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis."
Elliott D.J.
Int. J. Androl. 27:328-334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH KHDRBS1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U36608 expand/collapse EMBL AC list , U36604, U36605, U36606, U36607 Genomic DNA. Translation: AAC16917.1.
U36610, U36609 Genomic DNA. Translation: AAC16918.1.
PIRA49418.

3D structure databases

ProteinModelPortalP0DJD4.
SMRP0DJD4. Positions 1-108.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM378522970.

Proteomic databases

PRIDEP0DJD4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC0YU900014.
HGNCHGNC:9914. RBMY1C.
HPAHPA001534.
MIM400006. gene.
neXtProtNX_P0DJD4.
GenAtlasSearch...

Gene expression databases

CleanExHS_RBMY1A1.

Family and domain databases

Gene3D3.30.70.330. 1 hit.
InterProIPR012677. Nucleotide-bd_a/b_plait.
IPR012604. RBM1CTR.
IPR000504. RRM_dom.
[Graphical view]
PfamPF08081. RBM1CTR. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTSM00360. RRM. 1 hit.
[Graphical view]
PROSITEPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP0DJD4.
SOURCESearch...

Entry information

Entry nameRBY1C_HUMAN
AccessionPrimary (citable) accession number: P0DJD4
Secondary accession number(s): Q15376 expand/collapse secondary AC list , Q15377, Q15414, Q6NSB5, Q86VU6, Q8NHR0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: February 22, 2012
Last modified: April 16, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome Y

Human chromosome Y: entries, gene names and cross-references to MIM