P0DJD4 (RBY1C_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified April 3, 2013. Version 8. History...
Names and origin
|Protein names||Recommended name:|
RNA-binding motif protein, Y chromosome, family 1 member C
|Organism||Homo sapiens (Human) [Reference proteome]|
|Taxonomic identifier||9606 [NCBI]|
|Taxonomic lineage||Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo|
|Sequence length||496 AA.|
|Protein existence||Evidence at protein level|
General annotation (Comments)
RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.
Expressed in all of the transcriptionally active stages of germ cell development from spermatogonia through spermatocytes to round spermatids. Ref.2
The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.
Contains 1 RRM (RNA recognition motif) domain.
|Biological process||mRNA processing|
|Technical term||Complete proteome|
|Gene Ontology (GO)|
Inferred from electronic annotation. Source: UniProtKB-KWmRNA processing
Inferred from electronic annotation. Source: UniProtKB-KW
Inferred from electronic annotation. Source: UniProtKB-SubCell
Inferred from electronic annotation. Source: UniProtKB-KWnucleotide binding
Inferred from electronic annotation. Source: InterPro
|Complete GO annotation...|
Sequence annotation (Features)
|||"Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene."|
Chai N.-N., Zhou H., Hernandez J., Najmabadi H., Bhasin S., Yen P.H.
Genomics 49:283-289(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-220 AND 332-496.
|||"Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm."|
Elliott D.J., Millar M.R., Oghene K., Ross A., Kiesewetter F., Pryor J., McIntyre M., Hargreave T.B., Saunders P.T.K., Vogt P.H., Chandley A.C., Cooke H.
Proc. Natl. Acad. Sci. U.S.A. 94:3848-3853(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
|||"T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis."|
Venables J.P., Vernet C., Chew S.L., Elliott D.J., Cowmeadow R.B., Wu J., Cooke H.J., Artzt K., Eperon I.C.
Hum. Mol. Genet. 8:959-969(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH KHDRBS3.
|||"RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing."|
Venables J.P., Elliott D.J., Makarova O.V., Makarov E.M., Cooke H.J., Eperon E.C.
Hum. Mol. Genet. 9:685-694(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TRA2B.
|||"The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis."|
Int. J. Androl. 27:328-334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH KHDRBS1.
|U36608 U36607 Genomic DNA. Translation: AAC16917.1.|
U36610, U36609 Genomic DNA. Translation: AAC16918.1.
3D structure databases
|SMR||P0DJD4. Positions 1-108. |
Protocols and materials databases
|HGNC||HGNC:9914. RBMY1C. |
|MIM||400006. gene. |
Gene expression databases
|GermOnline||ENSG00000174622. Homo sapiens. |
Family and domain databases
|Gene3D||18.104.22.1680. 1 hit. |
|InterPro||IPR012677. Nucleotide-bd_a/b_plait. |
|Pfam||PF08081. RBM1CTR. 1 hit. |
PF00076. RRM_1. 1 hit.
|SMART||SM00360. RRM. 1 hit. |
|PROSITE||PS50102. RRM. 1 hit. |
|Accession||Primary (citable) accession number: P0DJD4|
Secondary accession number(s): Q15376 Q8NHR0
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Chordata Protein Annotation Program|
|Disclaimer||Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.|