Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RANBP2-like and GRIP domain-containing protein 2

Gene

RGPD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
RANBP2-like and GRIP domain-containing protein 2
Alternative name(s):
Ran-binding protein 2-like 2
Short name:
RanBP2-like 2
Short name:
RanBP2L2
Gene namesi
Name:RGPD2
Synonyms:RANBP2L2, RGP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000185304.13
HGNCiHGNC:32415 RGPD2
MIMi612705 gene
neXtProtiNX_P0DJD1

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi729857
OpenTargetsiENSG00000185304

Polymorphism and mutation databases

BioMutaiRGPD2
DMDMi374253661

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004153561 – 1756RANBP2-like and GRIP domain-containing protein 2Add BLAST1756

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP0DJD1
PaxDbiP0DJD1
PeptideAtlasiP0DJD1
PRIDEiP0DJD1

PTM databases

iPTMnetiP0DJD1
PhosphoSitePlusiP0DJD1

Expressioni

Gene expression databases

BgeeiENSG00000185304
ExpressionAtlasiP0DJD1 baseline and differential
GenevisibleiP0DJD1 HS

Organism-specific databases

HPAiHPA049497
HPA051675
HPA067564

Interactioni

Protein-protein interaction databases

BioGridi610251, 9 interactors
STRINGi9606.ENSP00000381214

Structurei

3D structure databases

ProteinModelPortaliP0DJD1
SMRiP0DJD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati59 – 92TPR 1Add BLAST34
Repeati583 – 616TPR 2Add BLAST34
Repeati647 – 680TPR 3Add BLAST34
Domaini1029 – 1165RanBD1 1PROSITE-ProRule annotationAdd BLAST137
Domaini1326 – 1462RanBD1 2PROSITE-ProRule annotationAdd BLAST137
Domaini1693 – 1743GRIPPROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0864 Eukaryota
COG5171 LUCA
GeneTreeiENSGT00760000119119
InParanoidiP0DJD1
KOiK12172
OMAiVIMTISE
OrthoDBiEOG091G0BGL
PhylomeDBiP0DJD1
TreeFamiTF314797

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR032023 GCC2_Rab_bind
IPR000237 GRIP_dom
IPR011993 PH-like_dom_sf
IPR000156 Ran_bind_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF01465 GRIP, 1 hit
PF16704 Rab_bind, 1 hit
PF00638 Ran_BP1, 2 hits
SMARTiView protein in SMART
SM00755 Grip, 1 hit
SM00160 RanBD, 2 hits
SM00028 TPR, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50913 GRIP, 1 hit
PS50196 RANBD1, 2 hits
PS50005 TPR, 1 hit
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

P0DJD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRSKAYGER YLASVQGSAP SPGKKLRGFY FAKLYYEAKE YDLAKKYVCT
60 70 80 90 100
YLSVQERDPR AHRFLGLLYE LEENTEKAVE CYRRSLELNP PQKDLVLKIA
110 120 130 140 150
ELLCKNDVTD GRAKYWVERA AKLFPGSPAI YKLKEHLLDC EGEDGWNKLF
160 170 180 190 200
DWIQSELYVR PDDVHMNIRL VELYRSNKRL KDAVARCHEA ERNIALRSSL
210 220 230 240 250
EWNSCVVQTL KEYLESLQCL ESDKSDWRAT NTDLLLAYAN LMLLTLSTRD
260 270 280 290 300
VQESRELLES FDSALQSAKS SLGGNDELSA TFLEMKGHFY MHAGSLLLKM
310 320 330 340 350
GQHGNNVQWQ ALSELAALCY VIAFQVPRPK IKLIKGEAGQ NLLEMMACDR
360 370 380 390 400
LSQSGHMLLN LSRGKQDFLK EVVETFANKS GQSVLYNALF SSQSSKDTSF
410 420 430 440 450
LGSDDIGNID VQEPELEDLA RYDVGAIQAH NGSLQHLTWL GLQWNSLPAL
460 470 480 490 500
PGIRKWLKQL FHHLPQETSR LETNAPESIC ILDLEVFLLG VVYTSHLQLK
510 520 530 540 550
EKCNSHHSSY QPLCLPLPVC KRLCTERQKS WWDAVCTLIH RKAVPGNSAE
560 570 580 590 600
LRLVVQHEIN TLRAQEKHGL QPALLVHWAK CLQKMGRGLN SSYDQQEYIG
610 620 630 640 650
RSVHYWKKVL PLLKIIKKNS IPEPIDPLFK HFHSVDIQAS EIVEYEEDAH
660 670 680 690 700
ITFAILDAVH GNIEDAVTAF ESIKSVVSYW NLALIFHRKA EDIENDAVFP
710 720 730 740 750
EEQEECKNYL RKTRDYLIKI IDDSDSNLSV VKKLPVPLES VKEMLKSVMQ
760 770 780 790 800
ELEDYSEGGP LYKNGSLRNA DSEIKHSTPS PTKYSLSPSK SYKYSPKTPP
810 820 830 840 850
RWAEDQNSLR KMICQEVKAI TKLNSSKSAS RHRWPTENYG PDSVPDGYQG
860 870 880 890 900
SQTFHGAPLT VATTGPSVYY SQSPAYNSQY LLRPAANVTP TKGSSNTEFK
910 920 930 940 950
STKEGFSIAV SADGFKFGIS EPGNQEKKSE KPLENDTGFQ AQDISGQKNG
960 970 980 990 1000
RGVIFGQTSS TFTFADVAKS TSGEGFQFGK KDPNFKGFSG AGEKLFSSQC
1010 1020 1030 1040 1050
GKMANKANTS GDFEKDDDAC KTEDSDDIHF EPVVQMPEKV ELVTGEEGEK
1060 1070 1080 1090 1100
VLYSQGVKLF RFDAEISQWK ERGLGNLKIL KNEVNGKPRM LMRRDQVLKV
1110 1120 1130 1140 1150
CANHWITTTM NLKPLSGSDR AWMWLASDFS DGDAKLERLA AQFKTPELAE
1160 1170 1180 1190 1200
EFKQKFEECQ RLLLDIPLQT PHKLVDTGRA AKLIQRAEEM KSGLKDFKTF
1210 1220 1230 1240 1250
LTNDQTKVTE EENKGSGTGA AGASDTTIKP NPENTGPTLE WDNYDLREDA
1260 1270 1280 1290 1300
LDDNVSSSSV HDSPLASSPV RKNIFRFDES TTGFNFSFKS ALSLSKSPAK
1310 1320 1330 1340 1350
LNQSGTSVGT DEESDVTQEE ERDGQYFEPV VPLPDLVEVS SGEENEQVVF
1360 1370 1380 1390 1400
SHMAELYRYD KDVGQWKERG IGDIKILQNY DNKQVRIVMR RDQVLKLCAN
1410 1420 1430 1440 1450
HRITPDMSLQ NMKGTERVWV WTACDFADGE RKVEHLAVRF KLQDVADSFK
1460 1470 1480 1490 1500
KIFDEAKTAQ EKDSLITPHV SRSSTPRESP CGKIAVAVLE ETTRERTDVI
1510 1520 1530 1540 1550
QGDDVADAAS EVEVSSTSET TTKAVVSPPK FVFGSESVKR IFSSEKSNPF
1560 1570 1580 1590 1600
AFGNSSATGS LFGFSFNAPL KSNDSETSSV AQSGSESKVE PKKCELSKNS
1610 1620 1630 1640 1650
DIEQSSDSKV KNLSASFPME ESSINYTFKT PEKEPPLWHA EFTKEELVQK
1660 1670 1680 1690 1700
LSSTTKSADQ LNGLLRETEA TSAVLMEQIK LLKSEIRRLE RNQEESAANV
1710 1720 1730 1740 1750
EHLKNVLLQF IFLKPGSERE SLLPVINTML QLSPEEKGKL AAVAQGLQET

SIPKKK
Length:1,756
Mass (Da):197,308
Last modified:January 25, 2012 - v1
Checksum:iAF734EAD7BBFA429
GO

Sequence cautioni

The sequence AAQ63888 differs from that shown. Probable cloning artifact.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093616 Genomic DNA No translation available.
AY354203 mRNA Translation: AAQ63888.1 Sequence problems.
CCDSiCCDS42710.2
RefSeqiNP_001071638.2, NM_001078170.2
UniGeneiHs.652430
Hs.728970

Genome annotation databases

EnsembliENST00000398146; ENSP00000381214; ENSG00000185304
GeneIDi729857
KEGGihsa:729857
UCSCiuc010fhc.3 human

Similar proteinsi

Entry informationi

Entry nameiRGPD2_HUMAN
AccessioniPrimary (citable) accession number: P0DJD1
Secondary accession number(s): P0C839, Q68DN6, Q6V1X0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: January 25, 2012
Last modified: March 28, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health