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Protein

RANBP2-like and GRIP domain-containing protein 2

Gene

RGPD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
RANBP2-like and GRIP domain-containing protein 2
Alternative name(s):
Ran-binding protein 2-like 2
Short name:
RanBP2-like 2
Short name:
RanBP2L2
Gene namesi
Name:RGPD2
Synonyms:RANBP2L2, RGP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:32415. RGPD2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiRGPD2.
DMDMi374253661.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17561756RANBP2-like and GRIP domain-containing protein 2PRO_0000415356Add
BLAST

Proteomic databases

EPDiP0DJD1.
MaxQBiP0DJD1.
PaxDbiP0DJD1.
PeptideAtlasiP0DJD1.
PRIDEiP0DJD1.

PTM databases

iPTMnetiP0DJD1.

Expressioni

Gene expression databases

BgeeiP0DJD1.
GenevisibleiP0DJD1. HS.

Organism-specific databases

HPAiHPA049497.
HPA051675.

Interactioni

Protein-protein interaction databases

BioGridi610251. 8 interactions.
STRINGi9606.ENSP00000381214.

Structurei

3D structure databases

ProteinModelPortaliP0DJD1.
SMRiP0DJD1. Positions 2-144, 1044-1171, 1664-1693.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati59 – 9234TPR 1Add
BLAST
Repeati583 – 61634TPR 2Add
BLAST
Repeati647 – 68034TPR 3Add
BLAST
Domaini1029 – 1165137RanBD1 1PROSITE-ProRule annotationAdd
BLAST
Domaini1326 – 1462137RanBD1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1693 – 174351GRIPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GRIP domain.PROSITE-ProRule annotation
Contains 2 RanBD1 domains.PROSITE-ProRule annotation
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0864. Eukaryota.
COG5171. LUCA.
GeneTreeiENSGT00840000129823.
InParanoidiP0DJD1.
KOiK12172.
OMAiVIMTISE.
OrthoDBiEOG7X0VG5.
PhylomeDBiP0DJD1.
TreeFamiTF314797.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
1.25.40.10. 2 hits.
2.30.29.30. 2 hits.
InterProiIPR032023. GCC2_Rab_bind.
IPR000237. GRIP_dom.
IPR011993. PH_dom-like.
IPR000156. Ran_bind_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
PF16704. Rab_bind. 1 hit.
PF00638. Ran_BP1. 2 hits.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
SM00160. RanBD. 2 hits.
SM00028. TPR. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50913. GRIP. 1 hit.
PS50196. RANBD1. 2 hits.
PS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0DJD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRSKAYGER YLASVQGSAP SPGKKLRGFY FAKLYYEAKE YDLAKKYVCT
60 70 80 90 100
YLSVQERDPR AHRFLGLLYE LEENTEKAVE CYRRSLELNP PQKDLVLKIA
110 120 130 140 150
ELLCKNDVTD GRAKYWVERA AKLFPGSPAI YKLKEHLLDC EGEDGWNKLF
160 170 180 190 200
DWIQSELYVR PDDVHMNIRL VELYRSNKRL KDAVARCHEA ERNIALRSSL
210 220 230 240 250
EWNSCVVQTL KEYLESLQCL ESDKSDWRAT NTDLLLAYAN LMLLTLSTRD
260 270 280 290 300
VQESRELLES FDSALQSAKS SLGGNDELSA TFLEMKGHFY MHAGSLLLKM
310 320 330 340 350
GQHGNNVQWQ ALSELAALCY VIAFQVPRPK IKLIKGEAGQ NLLEMMACDR
360 370 380 390 400
LSQSGHMLLN LSRGKQDFLK EVVETFANKS GQSVLYNALF SSQSSKDTSF
410 420 430 440 450
LGSDDIGNID VQEPELEDLA RYDVGAIQAH NGSLQHLTWL GLQWNSLPAL
460 470 480 490 500
PGIRKWLKQL FHHLPQETSR LETNAPESIC ILDLEVFLLG VVYTSHLQLK
510 520 530 540 550
EKCNSHHSSY QPLCLPLPVC KRLCTERQKS WWDAVCTLIH RKAVPGNSAE
560 570 580 590 600
LRLVVQHEIN TLRAQEKHGL QPALLVHWAK CLQKMGRGLN SSYDQQEYIG
610 620 630 640 650
RSVHYWKKVL PLLKIIKKNS IPEPIDPLFK HFHSVDIQAS EIVEYEEDAH
660 670 680 690 700
ITFAILDAVH GNIEDAVTAF ESIKSVVSYW NLALIFHRKA EDIENDAVFP
710 720 730 740 750
EEQEECKNYL RKTRDYLIKI IDDSDSNLSV VKKLPVPLES VKEMLKSVMQ
760 770 780 790 800
ELEDYSEGGP LYKNGSLRNA DSEIKHSTPS PTKYSLSPSK SYKYSPKTPP
810 820 830 840 850
RWAEDQNSLR KMICQEVKAI TKLNSSKSAS RHRWPTENYG PDSVPDGYQG
860 870 880 890 900
SQTFHGAPLT VATTGPSVYY SQSPAYNSQY LLRPAANVTP TKGSSNTEFK
910 920 930 940 950
STKEGFSIAV SADGFKFGIS EPGNQEKKSE KPLENDTGFQ AQDISGQKNG
960 970 980 990 1000
RGVIFGQTSS TFTFADVAKS TSGEGFQFGK KDPNFKGFSG AGEKLFSSQC
1010 1020 1030 1040 1050
GKMANKANTS GDFEKDDDAC KTEDSDDIHF EPVVQMPEKV ELVTGEEGEK
1060 1070 1080 1090 1100
VLYSQGVKLF RFDAEISQWK ERGLGNLKIL KNEVNGKPRM LMRRDQVLKV
1110 1120 1130 1140 1150
CANHWITTTM NLKPLSGSDR AWMWLASDFS DGDAKLERLA AQFKTPELAE
1160 1170 1180 1190 1200
EFKQKFEECQ RLLLDIPLQT PHKLVDTGRA AKLIQRAEEM KSGLKDFKTF
1210 1220 1230 1240 1250
LTNDQTKVTE EENKGSGTGA AGASDTTIKP NPENTGPTLE WDNYDLREDA
1260 1270 1280 1290 1300
LDDNVSSSSV HDSPLASSPV RKNIFRFDES TTGFNFSFKS ALSLSKSPAK
1310 1320 1330 1340 1350
LNQSGTSVGT DEESDVTQEE ERDGQYFEPV VPLPDLVEVS SGEENEQVVF
1360 1370 1380 1390 1400
SHMAELYRYD KDVGQWKERG IGDIKILQNY DNKQVRIVMR RDQVLKLCAN
1410 1420 1430 1440 1450
HRITPDMSLQ NMKGTERVWV WTACDFADGE RKVEHLAVRF KLQDVADSFK
1460 1470 1480 1490 1500
KIFDEAKTAQ EKDSLITPHV SRSSTPRESP CGKIAVAVLE ETTRERTDVI
1510 1520 1530 1540 1550
QGDDVADAAS EVEVSSTSET TTKAVVSPPK FVFGSESVKR IFSSEKSNPF
1560 1570 1580 1590 1600
AFGNSSATGS LFGFSFNAPL KSNDSETSSV AQSGSESKVE PKKCELSKNS
1610 1620 1630 1640 1650
DIEQSSDSKV KNLSASFPME ESSINYTFKT PEKEPPLWHA EFTKEELVQK
1660 1670 1680 1690 1700
LSSTTKSADQ LNGLLRETEA TSAVLMEQIK LLKSEIRRLE RNQEESAANV
1710 1720 1730 1740 1750
EHLKNVLLQF IFLKPGSERE SLLPVINTML QLSPEEKGKL AAVAQGLQET

SIPKKK
Length:1,756
Mass (Da):197,308
Last modified:January 25, 2012 - v1
Checksum:iAF734EAD7BBFA429
GO

Sequence cautioni

The sequence AAQ63888.1 differs from that shown.Probable cloning artifact.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093616 Genomic DNA. No translation available.
AY354203 mRNA. Translation: AAQ63888.1. Sequence problems.
CCDSiCCDS42710.2.
RefSeqiNP_001071638.2. NM_001078170.2.
UniGeneiHs.652430.
Hs.728970.

Genome annotation databases

EnsembliENST00000398146; ENSP00000381214; ENSG00000185304.
GeneIDi729857.
KEGGihsa:729857.
UCSCiuc010fhc.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093616 Genomic DNA. No translation available.
AY354203 mRNA. Translation: AAQ63888.1. Sequence problems.
CCDSiCCDS42710.2.
RefSeqiNP_001071638.2. NM_001078170.2.
UniGeneiHs.652430.
Hs.728970.

3D structure databases

ProteinModelPortaliP0DJD1.
SMRiP0DJD1. Positions 2-144, 1044-1171, 1664-1693.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi610251. 8 interactions.
STRINGi9606.ENSP00000381214.

PTM databases

iPTMnetiP0DJD1.

Polymorphism and mutation databases

BioMutaiRGPD2.
DMDMi374253661.

Proteomic databases

EPDiP0DJD1.
MaxQBiP0DJD1.
PaxDbiP0DJD1.
PeptideAtlasiP0DJD1.
PRIDEiP0DJD1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398146; ENSP00000381214; ENSG00000185304.
GeneIDi729857.
KEGGihsa:729857.
UCSCiuc010fhc.3. human.

Organism-specific databases

CTDi729857.
GeneCardsiRGPD2.
HGNCiHGNC:32415. RGPD2.
HPAiHPA049497.
HPA051675.
MIMi612705. gene.
neXtProtiNX_P0DJD1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0864. Eukaryota.
COG5171. LUCA.
GeneTreeiENSGT00840000129823.
InParanoidiP0DJD1.
KOiK12172.
OMAiVIMTISE.
OrthoDBiEOG7X0VG5.
PhylomeDBiP0DJD1.
TreeFamiTF314797.

Miscellaneous databases

ChiTaRSiRGPD2. human.
GenomeRNAii729857.
PROiP0DJD1.
SOURCEiSearch...

Gene expression databases

BgeeiP0DJD1.
GenevisibleiP0DJD1. HS.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
1.25.40.10. 2 hits.
2.30.29.30. 2 hits.
InterProiIPR032023. GCC2_Rab_bind.
IPR000237. GRIP_dom.
IPR011993. PH_dom-like.
IPR000156. Ran_bind_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
PF16704. Rab_bind. 1 hit.
PF00638. Ran_BP1. 2 hits.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
SM00160. RanBD. 2 hits.
SM00028. TPR. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50913. GRIP. 1 hit.
PS50196. RANBD1. 2 hits.
PS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Sha J.H., Zhou Z.M., Li J.M.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 660-1756.
    Tissue: Testis.

Entry informationi

Entry nameiRGPD2_HUMAN
AccessioniPrimary (citable) accession number: P0DJD1
Secondary accession number(s): P0C839, Q68DN6, Q6V1X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: January 25, 2012
Last modified: July 6, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.