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Protein

RANBP2-like and GRIP domain-containing protein 1

Gene

RGPD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
RANBP2-like and GRIP domain-containing protein 1
Alternative name(s):
Ran-binding protein 2-like 6
Short name:
RanBP2-like 6
Short name:
RanBP2L6
Gene namesi
Name:RGPD1
Synonyms:RANBP2L6, RGP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:32414. RGPD1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187627.

Polymorphism and mutation databases

BioMutaiRGPD1.
DMDMi374253660.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002049191 – 1748RANBP2-like and GRIP domain-containing protein 1Add BLAST1748

Proteomic databases

EPDiP0DJD0.
MaxQBiP0DJD0.
PaxDbiP0DJD0.
PeptideAtlasiP0DJD0.
PRIDEiP0DJD0.

PTM databases

iPTMnetiP0DJD0.
PhosphoSitePlusiP0DJD0.
SwissPalmiP0DJD0.

Expressioni

Gene expression databases

BgeeiENSG00000187627.
ExpressionAtlasiP0DJD0. baseline and differential.
GenevisibleiP0DJD0. HS.

Organism-specific databases

HPAiHPA049497.
HPA051675.

Interactioni

Protein-protein interaction databases

BioGridi134847. 6 interactors.
IntActiP0DJD0. 2 interactors.
STRINGi9606.ENSP00000381253.

Structurei

3D structure databases

ProteinModelPortaliP0DJD0.
SMRiP0DJD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati51 – 84TPR 1Add BLAST34
Repeati575 – 608TPR 2Add BLAST34
Repeati639 – 672TPR 3Add BLAST34
Domaini1021 – 1157RanBD1 1PROSITE-ProRule annotationAdd BLAST137
Domaini1318 – 1454RanBD1 2PROSITE-ProRule annotationAdd BLAST137
Domaini1685 – 1735GRIPPROSITE-ProRule annotationAdd BLAST51

Sequence similaritiesi

Contains 1 GRIP domain.PROSITE-ProRule annotation
Contains 2 RanBD1 domains.PROSITE-ProRule annotation
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0864. Eukaryota.
COG5171. LUCA.
GeneTreeiENSGT00840000129823.
InParanoidiP0DJD0.
KOiK12172.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
1.25.40.10. 2 hits.
2.30.29.30. 2 hits.
InterProiIPR032023. GCC2_Rab_bind.
IPR000237. GRIP_dom.
IPR011993. PH_dom-like.
IPR000156. Ran_bind_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
PF16704. Rab_bind. 1 hit.
PF00638. Ran_BP1. 2 hits.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
SM00160. RanBD. 2 hits.
SM00028. TPR. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50913. GRIP. 1 hit.
PS50196. RANBD1. 2 hits.
PS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0DJD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVMGFNTDR LAWTRNKLRG FYFAKLYYEA KEYDLAKKYV CTYLSVQERD
60 70 80 90 100
PRAHRFLGLL YELEENTEKA VECYRRSLEL NPPQKDLVLK IAELLCKNDV
110 120 130 140 150
TDGRAKYWVE RAAKLFPGSP AIYKLKEHLL DCEGEDGWNK LFDWIQSELY
160 170 180 190 200
VRPDDVHMNI RLVELYRSNK RLKDAVARCH EAERNIALRS SLEWNSCVVQ
210 220 230 240 250
TLKEYLESLQ CLESDKSDWR ATNTDLLLAY ANLMLLTLST RDVQESRELL
260 270 280 290 300
ESFDSALQSA KSSLGGNDEL SATFLEMKGH FYMHAGSLLL KMGQHGNNVQ
310 320 330 340 350
WQALSELAAL CYVIAFQVPR PKIKLIKGEA GQNLLEMMAC DRLSQSGHML
360 370 380 390 400
LNLSRGKQDF LKEVVETFAN KSGQSVLYNA LFSSQSSKDT SFLGSDDIGN
410 420 430 440 450
IDVQEPELED LARYDVGAIQ AHNGSLQHLT WLGLQWNSLP ALPGIRKWLK
460 470 480 490 500
QLFHHLPQET SRLETNAPES ICILDLEVFL LGVVYTSHLQ LKEKCNSHHS
510 520 530 540 550
SYQPLCLPLP VCKRLCTERQ KSWWDAVCTL IHRKAVPGNS AELRLVVQHE
560 570 580 590 600
INTLRAQEKH GLQPALLVHW AKCLQKMGRG LNSSYDQQEY IGRSVHYWKK
610 620 630 640 650
VLPLLKIIKK NSIPEPIDPL FKHFHSVDIQ ASEIVEYEED AHITFAILDA
660 670 680 690 700
VHGNIEDAVT AFESIKSVVS YWNLALIFHR KAEDIENDAV FPEEQEECKN
710 720 730 740 750
YLRKTRDYLI KIIDDSDSNL SVVKKLPVPL ESVKEMLKSV MQELEDYSEG
760 770 780 790 800
GPLYKNGSLR NADSEIKHST PSPTKYSLSP SKSYKYSPKT PPRWAEDQNS
810 820 830 840 850
LRKMICQEVK AITKLNSSKS ASRHRWPTEN YGPDSVPDGY QGSQTFHGAP
860 870 880 890 900
LTVATTGPSV YYSQSPAYNS QYLLRPAANV TPTKGSSNTE FKSTKEGFSI
910 920 930 940 950
AVSADGFKFG ISEPGNQEKK SEKPLENDTG FQAQDISGQK NGRGVIFGQT
960 970 980 990 1000
SSTFTFADVA KSTSGEGFQF GKKDPNFKGF SGAGEKLFSS QCGKMANKAN
1010 1020 1030 1040 1050
TSGDFEKDDD ACKTEDSDDI HFEPVVQMPE KVELVTGEEG EKVLYSQGVK
1060 1070 1080 1090 1100
LFRFDAEISQ WKERGLGNLK ILKNEVNGKP RMLMRRDQVL KVCANHWITT
1110 1120 1130 1140 1150
TMNLKPLSGS DRAWMWLASD FSDGDAKLER LAAQFKTPEL AEEFKQKFEE
1160 1170 1180 1190 1200
CQRLLLDIPL QTPHKLVDTG RAAKLIQRAE EMKSGLKDFK TFLTNDQTKV
1210 1220 1230 1240 1250
TEEENKGSGT GAAGASDTTI KPNPENTGPT LEWDNYDLRE DALDDNVSSS
1260 1270 1280 1290 1300
SVHDSPLASS PVRKNIFRFD ESTTGFNFSF KSALSLSKSP AKLNQSGTSV
1310 1320 1330 1340 1350
GTDEESDVTQ EEERDGQYFE PVVPLPDLVE VSSGEENEQV VFSHRAELYR
1360 1370 1380 1390 1400
YDKDVGQWKE RGIGDIKILQ NYDNKQVRIV MRRDQVLKLC ANHRITPDMS
1410 1420 1430 1440 1450
LQNMKGTERV WVWTACDFAD GERKVEHLAV RFKLQDVADS FKKIFDEAKT
1460 1470 1480 1490 1500
AQEKDSLITP HVSRSSTPRE SPCGKIAVAV LEETTRERTD VIQGDDVADA
1510 1520 1530 1540 1550
ASEVEVSSTS ETTTKAVVSP PKFVFGSESV KRIFSSEKSN PFAFGNSSAT
1560 1570 1580 1590 1600
GSLFGFSFNA PLKSNDSETS SVAQSGSESK VEPKKCELSK NSDIEQSSDS
1610 1620 1630 1640 1650
KVKNLSASFP MEESSINYTF KTPEKEPPLW HAEFTKEELV QKLSSTTKSA
1660 1670 1680 1690 1700
DQLNGLLRET EATSAVLMEQ IKLLKSEIRR LERNQEESAA NVEHLKNVLL
1710 1720 1730 1740
QFIFLKPGSE RESLLPVINT MLQLSPEEKG KLAAVAQGLQ ETSIPKKK
Length:1,748
Mass (Da):196,662
Last modified:January 25, 2012 - v1
Checksum:iF714EAF3129B388A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1212A → S in CAH18184 (PubMed:17974005).Curated1
Sequence conflicti1596Q → H in CAH18184 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749330 mRNA. Translation: CAH18184.1.
AC111200 Genomic DNA. No translation available.
CCDSiCCDS46358.2.
RefSeqiNP_001019628.3. NM_001024457.3.
UniGeneiHs.728970.

Genome annotation databases

EnsembliENST00000409776; ENSP00000386808; ENSG00000187627.
ENST00000559485; ENSP00000453170; ENSG00000187627.
GeneIDi400966.
KEGGihsa:400966.
UCSCiuc021vkh.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749330 mRNA. Translation: CAH18184.1.
AC111200 Genomic DNA. No translation available.
CCDSiCCDS46358.2.
RefSeqiNP_001019628.3. NM_001024457.3.
UniGeneiHs.728970.

3D structure databases

ProteinModelPortaliP0DJD0.
SMRiP0DJD0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134847. 6 interactors.
IntActiP0DJD0. 2 interactors.
STRINGi9606.ENSP00000381253.

PTM databases

iPTMnetiP0DJD0.
PhosphoSitePlusiP0DJD0.
SwissPalmiP0DJD0.

Polymorphism and mutation databases

BioMutaiRGPD1.
DMDMi374253660.

Proteomic databases

EPDiP0DJD0.
MaxQBiP0DJD0.
PaxDbiP0DJD0.
PeptideAtlasiP0DJD0.
PRIDEiP0DJD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409776; ENSP00000386808; ENSG00000187627.
ENST00000559485; ENSP00000453170; ENSG00000187627.
GeneIDi400966.
KEGGihsa:400966.
UCSCiuc021vkh.2. human.

Organism-specific databases

CTDi400966.
GeneCardsiRGPD1.
HGNCiHGNC:32414. RGPD1.
HPAiHPA049497.
HPA051675.
MIMi612704. gene.
neXtProtiNX_P0DJD0.
OpenTargetsiENSG00000187627.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0864. Eukaryota.
COG5171. LUCA.
GeneTreeiENSGT00840000129823.
InParanoidiP0DJD0.
KOiK12172.

Miscellaneous databases

ChiTaRSiRGPD1. human.
GenomeRNAii400966.
PROiP0DJD0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187627.
ExpressionAtlasiP0DJD0. baseline and differential.
GenevisibleiP0DJD0. HS.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
1.25.40.10. 2 hits.
2.30.29.30. 2 hits.
InterProiIPR032023. GCC2_Rab_bind.
IPR000237. GRIP_dom.
IPR011993. PH_dom-like.
IPR000156. Ran_bind_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
PF16704. Rab_bind. 1 hit.
PF00638. Ran_BP1. 2 hits.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
SM00160. RanBD. 2 hits.
SM00028. TPR. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50913. GRIP. 1 hit.
PS50196. RANBD1. 2 hits.
PS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGPD1_HUMAN
AccessioniPrimary (citable) accession number: P0DJD0
Secondary accession number(s): P0C839, Q68DN6, Q6V1X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: January 25, 2012
Last modified: November 2, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.