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Protein

Small integral membrane protein 13

Gene

SMIM13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Small integral membrane protein 13
Gene namesi
Name:SMIM13
Synonyms:C6orf228
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:27356. SMIM13.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000224531.

Polymorphism and mutation databases

BioMutaiSMIM13.
DMDMi363579843.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004140601 – 91Small integral membrane protein 13Add BLAST91

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58PhosphoserineBy similarity1
Modified residuei60PhosphoserineBy similarity1
Modified residuei62PhosphothreonineBy similarity1
Modified residuei69PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP0DJ93.
MaxQBiP0DJ93.
PaxDbiP0DJ93.
PeptideAtlasiP0DJ93.
PRIDEiP0DJ93.
TopDownProteomicsiP0DJ93.

PTM databases

iPTMnetiP0DJ93.
PhosphoSitePlusiP0DJ93.

Expressioni

Gene expression databases

BgeeiENSG00000224531.
GenevisibleiP0DJ93. HS.

Organism-specific databases

HPAiHPA065706.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000451866.

Structurei

3D structure databases

ProteinModelPortaliP0DJ93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SMIM13 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J4X9. Eukaryota.
ENOG410YT20. LUCA.
GeneTreeiENSGT00560000078630.
InParanoidiP0DJ93.
OMAiMWHNVGL.
OrthoDBiEOG091G16CW.

Family and domain databases

InterProiIPR031851. DUF4750.
[Graphical view]
PfamiPF15938. DUF4750. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0DJ93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWHSVGLTLL VFVATLLIVL LLMVCGWYFV WHLFLSKFKF LRELVGDTGS
60 70 80 90
QEGDHEPSGS ETEEDTSSSP HRIRSARQRR APADEGHRPL T
Length:91
Mass (Da):10,351
Last modified:December 14, 2011 - v1
Checksum:i9394704F780C22A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136139 Genomic DNA. No translation available.
BC032356 mRNA. No translation available.
CCDSiCCDS56396.1.
RefSeqiNP_001129047.1. NM_001135575.1.
UniGeneiHs.656600.

Genome annotation databases

EnsembliENST00000376935; ENSP00000452219; ENSG00000224531.
ENST00000416247; ENSP00000451866; ENSG00000224531.
GeneIDi221710.
KEGGihsa:221710.
UCSCiuc011dio.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136139 Genomic DNA. No translation available.
BC032356 mRNA. No translation available.
CCDSiCCDS56396.1.
RefSeqiNP_001129047.1. NM_001135575.1.
UniGeneiHs.656600.

3D structure databases

ProteinModelPortaliP0DJ93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000451866.

PTM databases

iPTMnetiP0DJ93.
PhosphoSitePlusiP0DJ93.

Polymorphism and mutation databases

BioMutaiSMIM13.
DMDMi363579843.

Proteomic databases

EPDiP0DJ93.
MaxQBiP0DJ93.
PaxDbiP0DJ93.
PeptideAtlasiP0DJ93.
PRIDEiP0DJ93.
TopDownProteomicsiP0DJ93.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376935; ENSP00000452219; ENSG00000224531.
ENST00000416247; ENSP00000451866; ENSG00000224531.
GeneIDi221710.
KEGGihsa:221710.
UCSCiuc011dio.3. human.

Organism-specific databases

CTDi221710.
GeneCardsiSMIM13.
HGNCiHGNC:27356. SMIM13.
HPAiHPA065706.
neXtProtiNX_P0DJ93.
OpenTargetsiENSG00000224531.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4X9. Eukaryota.
ENOG410YT20. LUCA.
GeneTreeiENSGT00560000078630.
InParanoidiP0DJ93.
OMAiMWHNVGL.
OrthoDBiEOG091G16CW.

Miscellaneous databases

GenomeRNAii221710.
PROiP0DJ93.

Gene expression databases

BgeeiENSG00000224531.
GenevisibleiP0DJ93. HS.

Family and domain databases

InterProiIPR031851. DUF4750.
[Graphical view]
PfamiPF15938. DUF4750. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIM13_HUMAN
AccessioniPrimary (citable) accession number: P0DJ93
Secondary accession number(s): G3V581
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: December 14, 2011
Last modified: November 2, 2016
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.