UniProtKB - P0DJ41 (KKX51_HETLA)
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Protein
Potassium channel toxin kappa-KTx 5.1
Gene
N/A
Organism
Heterometrus laoticus (Thai giant scorpion)
Status
Functioni
Blocker of potassium channels Kv1.1/KCNA1 (EC(50)=9.9 µM) and Kv1.6/KCNA6. Acts by binding to the pore and occluding it. Has a voltage-dependent mode of action, which can be explained by a high content of basic residues causing repulsions at higher membrane voltages.1 Publication
Miscellaneous
Does not block or very poorly blocks Kv1.2/KCNA2, Kv1.3/KCNA3 (20%), Kv1.4/KCNA4 (13%), Kv1.5/KCNA5, Kv1.8/KCNA10, Kv2.1/KCNB1, Kv3.1/KCNC1, Kv4.2/KCND2, KCa2.3/KCNN3, KCa3.1/KCNN4.1 Publication
Keywordsi
| Molecular function | Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin |
Names & Taxonomyi
| Protein namesi | Recommended name: Potassium channel toxin kappa-KTx 5.11 PublicationAlternative name(s): HelaTx11 Publication |
| Organismi | Heterometrus laoticus (Thai giant scorpion) |
| Taxonomic identifieri | 217256 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Iurida › Scorpionoidea › Scorpionidae › Scorpioninae › Heterometrus |
Subcellular locationi
- Secreted 1 Publication
GO - Cellular componenti
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
| PropeptideiPRO_0000416812 | 24 – 43 | Add BLAST | 20 | |
| PeptideiPRO_0000416813 | 46 – 70 | Potassium channel toxin kappa-KTx 5.11 PublicationAdd BLAST | 25 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Disulfide bondi | 47 ↔ 64 | 1 Publication | ||
| Disulfide bondi | 51 ↔ 60 | 1 Publication | ||
| Modified residuei | 70 | Histidine amide1 Publication | 1 |
Keywords - PTMi
Amidation, Cleavage on pair of basic residues, Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Structurei
3D structure databases
| ProteinModelPortali | P0DJ41. |
| SMRi | P0DJ41. |
| ModBasei | Search... |
| MobiDBi | Search... |
Family & Domainsi
Domaini
Has the structural arrangement of two alpha-helices stabilized by two disulfide bonds (CSalpha/alpha 2(S-S)).1 Publication
Sequence similaritiesi
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor kappa-KTx family. Kappa-KTx 5 subfamily.Curated
Keywords - Domaini
SignalSequencei
Sequence statusi: Complete.
Sequence processingi: The displayed sequence is further processed into a mature form.
P0DJ41-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLLPLLFVI LIVCAILPDE ASCDQSELER KEENFKDESR EIVKRSCKKE
60 70
CSGSRRTKKC MQKCNREHGH GR
Mass spectrometryi
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JN872634 mRNA. Translation: AFB73757.1. |
Similar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:| 100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry. |
| 90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
| 50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |
Entry informationi
| Entry namei | KKX51_HETLA | |
| Accessioni | P0DJ41Primary (citable) accession number: P0DJ41 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2012 |
| Last sequence update: | April 18, 2012 | |
| Last modified: | May 10, 2017 | |
| This is version 15 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Animal Toxin Annotation Program | |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries - SIMILARITY comments
Index of protein domains and families
