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Protein

Potassium channel toxin kappa-KTx 2.8

Gene
N/A
Organism
Heterometrus petersii (Asian forest scorpion)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Voltage-gated potassium channel inhibitor (Kv) that acts on Kv1.3/KCNA3 and Kv7.1/KCNQ1. 1 µM of the toxin inhibits Kv1.3/KCNA3 currents by 35.1%, whereas 10 µM of the toxin inhibits Kv7.1/KCNQ1 currents by 44.9%.1 Publication

Miscellaneous

Does not show activity on ion channels KCa2.3/KCNN3, TRPV1, and KCa1.1/KCNMA1.1 Publication

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin kappa-KTx 2.81 Publication
Alternative name(s):
HSP053C.21 Publication
Toxin HeTx2041 Publication
Toxin kappa-KTx 2.71 Publication
OrganismiHeterometrus petersii (Asian forest scorpion)
Taxonomic identifieri754296 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaScorpionidaeScorpioninaeHeterometrus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei‹1 – 21Sequence analysisAdd BLAST›21
PropeptideiPRO_000041680022 – 35By similarityAdd BLAST14
PeptideiPRO_000041680138 – 61Potassium channel toxin kappa-KTx 2.8Add BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 59By similarity
Disulfide bondi45 ↔ 55By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Domaini

Has the structural arrangement of two alpha-helices stabilized by two disulfide bonds (CSalpha/alpha 2(S-S)).By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DJ35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GTVYVFLLLL AFGIFTDISN ACSEQMDDED SYEVEKRGNA CIEVCLQHTG
60
NPAECDKPCD K
Length:61
Mass (Da):6,748
Last modified:April 18, 2012 - v1
Checksum:iE31C93C933D42CBE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FD664204 mRNA. No translation available.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKKX28_HETPE
AccessioniPrimary (citable) accession number: P0DJ35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: April 18, 2012
Last modified: January 18, 2017
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families