UniProtKB - P0DJ35 (KKX28_HETPE)
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Protein
Potassium channel toxin kappa-KTx 2.8
Gene
N/A
Organism
Heterometrus petersii (Asian forest scorpion)
Status
Functioni
Voltage-gated potassium channel inhibitor (Kv) that acts on Kv1.3/KCNA3 and Kv7.1/KCNQ1. 1 µM of the toxin inhibits Kv1.3/KCNA3 currents by 35.1%, whereas 10 µM of the toxin inhibits Kv7.1/KCNQ1 currents by 44.9%.1 Publication
Miscellaneous
Does not show activity on ion channels KCa2.3/KCNN3, TRPV1, and KCa1.1/KCNMA1.1 Publication
Keywordsi
| Molecular function | Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin |
Names & Taxonomyi
| Protein namesi | Recommended name: Potassium channel toxin kappa-KTx 2.81 PublicationAlternative name(s): HSP053C.21 Publication Toxin HeTx2041 Publication Toxin kappa-KTx 2.71 Publication |
| Organismi | Heterometrus petersii (Asian forest scorpion) |
| Taxonomic identifieri | 754296 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Iurida › Scorpionoidea › Scorpionidae › Scorpioninae › Heterometrus |
Subcellular locationi
GO - Cellular componenti
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Signal peptidei | ‹1 – 21 | Sequence analysisAdd BLAST | ›21 | |
| PropeptideiPRO_0000416800 | 22 – 35 | By similarityAdd BLAST | 14 | |
| PeptideiPRO_0000416801 | 38 – 61 | Potassium channel toxin kappa-KTx 2.8Add BLAST | 24 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Disulfide bondi | 41 ↔ 59 | By similarity | ||
| Disulfide bondi | 45 ↔ 55 | By similarity |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.
Family & Domainsi
Domaini
Has the structural arrangement of two alpha-helices stabilized by two disulfide bonds (CSalpha/alpha 2(S-S)).By similarity
Sequence similaritiesi
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor kappa-KTx family. Kappa-KTx 2 subfamily.Curated
Keywords - Domaini
SignalSequencei
Sequence statusi: Fragment.
Sequence processingi: The displayed sequence is further processed into a mature form.
P0DJ35-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
GTVYVFLLLL AFGIFTDISN ACSEQMDDED SYEVEKRGNA CIEVCLQHTG
60
NPAECDKPCD K
Experimental Info
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Non-terminal residuei | 1 | 1 |
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FD664204 mRNA. No translation available. |
Similar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:| 100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry. |
| 90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
| 50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |
Entry informationi
| Entry namei | KKX28_HETPE | |
| Accessioni | P0DJ35Primary (citable) accession number: P0DJ35 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2012 |
| Last sequence update: | April 18, 2012 | |
| Last modified: | January 18, 2017 | |
| This is version 12 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Animal Toxin Annotation Program | |
Miscellaneousi
Documents
- Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries - SIMILARITY comments
Index of protein domains and families
