Potassium channel toxin alpha-KTx 23.2

Functionⁱ

Selectively and irreversibly binds (K(d)=2.9 pM) and blocks Kv1.3/KCNA3 potassium channels of human T-lymphocytes. Weakly blocks Kv1.2/KCNA2 (9%).1 Publication

Miscellaneous

Does not block hKCa3.1/KCNN4, and mKv1.1/KCNA1 channels (Ref. 1).

Has been patented as lead compound, candidates for the treatment of various autoimmune diseases and diagnostic applications (Ref. 1).

GO - Molecular functionⁱ

ion channel inhibitor activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

defense response Source: InterPro
pathogenesis Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Molecular function

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Potassium channel toxin alpha-KTx 23.2 Alternative name(s): Toxin Vm23 Toxin alpha-KTx 21.2
Organismⁱ	Vaejovis mexicanus smithi (Scorpion) (Vaejovis smithi)
Taxonomic identifierⁱ	1562928 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Iurida › Chactoidea › Vaejovidae › Vaejovis

Subcellular locationⁱ

Secreted

GO - Cellular componentⁱ

extracellular region Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000415930	1 – 35	Potassium channel toxin alpha-KTx 23.2Add BLAST		35

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	6 ↔ 26	By similarity
Disulfide bondⁱ	12 ↔ 31	By similarity
Disulfide bondⁱ	16 ↔ 33	By similarity

Keywords - PTMⁱ

Disulfide bond

Expressionⁱ

Tissue specificityⁱ

Expressed by the venom gland.

Structureⁱ

3D structure databases

SMRⁱ	P0DJ32.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 23 subfamily.Curated

Family and domain databases

Gene3Dⁱ	3.30.30.10. 1 hit.
InterProⁱ	View protein in InterPro IPR003614. Scorpion_toxin-like. IPR001947. Scorpion_toxinS_K_inh.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00451. Toxin_2. 1 hit.
PRINTSⁱ	PR00286. CHARYBDTOXIN.
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD003586. Scorpion_toxinS. 1 hit.
SUPFAMⁱ	SSF57095. SSF57095. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01138. SCORP_SHORT_TOXIN. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P0DJ32-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30 
AAAISCVGSK ECLPKCKAQG CKSGKCMNKK CKCYC

Length:35

Mass (Da):3,674

Last modified:March 21, 2012 - v1

Checksum:ⁱ8E8AF3CB7A0096F9

GO

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

3D structure databases

SMRⁱ	P0DJ32.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Family and domain databases

Gene3Dⁱ	3.30.30.10. 1 hit.
InterProⁱ	View protein in InterPro IPR003614. Scorpion_toxin-like. IPR001947. Scorpion_toxinS_K_inh.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00451. Toxin_2. 1 hit.
PRINTSⁱ	PR00286. CHARYBDTOXIN.
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD003586. Scorpion_toxinS. 1 hit.
SUPFAMⁱ	SSF57095. SSF57095. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01138. SCORP_SHORT_TOXIN. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KA232_VAEMS
Accessionⁱ	P0DJ32Primary (citable) accession number: P0DJ32
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 21, 2012
	Last sequence update:	March 21, 2012
	Last modified:	April 12, 2017
	This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Animal Toxin Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Direct protein sequencing

Documents

Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries
SIMILARITY comments
Index of protein domains and families

UniProtKB - P0DJ32 (KA232_VAEMS)

Your basket is currently empty.

Select a section on the left to see content.

Functionⁱ

Miscellaneous

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Expressionⁱ

Tissue specificityⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Family and domain databases

Sequenceⁱ

Similar proteinsⁱ

Cross-referencesⁱ

3D structure databases

Protocols and materials databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0DJ32 (KA232_VAEMS)

Your basket is currently empty.

Potassium channel toxin alpha-KTx 23.2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Protocols and materials databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ