P0DI97 (NRX1B_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 17.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Neurexin-1-beta Alternative name(s): Neurexin I-beta | ||
| Gene names |
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| Organism | Mus musculus (Mouse) [Reference proteome] | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 468 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis By similarity. |
| Subunit structure | The cytoplasmic C-terminal region binds to CASK. Isoforms 3b and 4b bind neuroligins NLGN1, NLGN2 and NLGN3, alpha-dystroglycan and alpha-latrotoxin. Binding to neuroligins is calcium-dependent, and the binding preference ranks as follow: NLGN1 > NLGN4 >> NLGN3 > NLGN2 By similarity. Interacts with CBLN1, CBLN2 and more weakly with CBLN4. CBLN1-binding is calcium-independent. Ref.2 Ref.3 |
| Subcellular location | Cell membrane; Single-pass type I membrane protein. Cell junction › synapse. Note: Localized on the pre-synaptic membrane By similarity. |
| Post-translational modification | Highly O-glycosylated and minor N-glycosylated By similarity. |
| Sequence similarities | Belongs to the neurexin family. Contains 1 laminin G-like domain. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| Cbln1 | Q9R171 | 4 | EBI-2794440,EBI-2794140 |
Alternative products
| This entry describes 5 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select] Note: A number of isoforms, alpha-type and beta-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus. | ||||||
| Isoform 1b (identifier: P0DI97-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 1a (identifier: Q9CS84-1) The sequence of this isoform can be found in the external entry Q9CS84. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. | ||||||
| Isoform 2a (identifier: Q9CS84-2) Also known as: Alpha-2B; The sequence of this isoform can be found in the external entry Q9CS84. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. | ||||||
| Isoform 3a (identifier: Q9CS84-3) Also known as: Alpha-2C; The sequence of this isoform can be found in the external entry Q9CS84. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. | ||||||
| Isoform 4a (identifier: Q9CS84-4) The sequence of this isoform can be found in the external entry Q9CS84. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 46 | 46 | Potential | ||||||
| Chain | 47 – 468 | 422 | Neurexin-1-beta | PRO_0000412630 | |||||
Regions | |||||||||
| Transmembrane | 393 – 413 | 21 | Helical; Potential | ||||||
| Domain | 87 – 285 | 199 | Laminin G-like | ||||||
| Compositional bias | 53 – 65 | 13 | His-rich | ||||||
| Compositional bias | 315 – 318 | 4 | Poly-Thr | ||||||
| Compositional bias | 400 – 403 | 4 | Poly-Ala | ||||||
Sites | |||||||||
| Metal binding | 137 | 1 | Calcium By similarity | ||||||
| Metal binding | 154 | 1 | Calcium; via carbonyl oxygen By similarity | ||||||
| Metal binding | 236 | 1 | Calcium; via carbonyl oxygen By similarity | ||||||
| Metal binding | 238 | 1 | Calcium By similarity | ||||||
Experimental info | |||||||||
| Mutagenesis | 137 | 1 | D → A: Loss of NLGN1-binding. No effect on CBLN1-binding. Ref.2 | ||||||
| Mutagenesis | 238 | 1 | N → A: Loss of NLGN1-binding. No effect on CBLN1-binding. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions." Matsuda K., Yuzaki M. Eur. J. Neurosci. 33:1447-1461(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CBLN1, MUTAGENESIS OF ASP-137 AND ASN-238. |
| [3] | "The Cbln family of proteins interact with multiple signaling pathways." Wei P., Pattarini R., Rong Y., Guo H., Bansal P.K., Kusnoor S.V., Deutch A.Y., Parris J., Morgan J.I. J. Neurochem. 121:717-729(2012) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CBLN1; CBLN2 AND CBLN4. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CH466537 Genomic DNA. Translation: EDL38657.1. |
| IPI | IPI01027669. |
| UniGene | Mm.312068. |
3D structure databases | |
| ProteinModelPortal | P0DI97. |
| SMR | P0DI97. Positions 84-288. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P0DI97. 2 interactions. |
Proteomic databases | |
| PRIDE | P0DI97. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000172466; ENSMUSP00000134402; ENSMUSG00000024109. |
Organism-specific databases | |
| MGI | MGI:1096391. Nrxn1. |
Phylogenomic databases | |
| GeneTree | ENSGT00560000076996. |
Gene expression databases | |
| ArrayExpress | P0DI97. |
| Bgee | P0DI97. |
Family and domain databases | |
| Gene3D | 2.60.120.200. 1 hit. |
| InterPro | IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR001791. Laminin_G. IPR003585. Neurexin-like. [Graphical view] |
| Pfam | PF02210. Laminin_G_2. 1 hit. [Graphical view] |
| SMART | SM00294. 4.1m. 1 hit. SM00282. LamG. 1 hit. [Graphical view] |
| SUPFAM | SSF49899. ConA_like_lec_gl. 1 hit. |
| PROSITE | PS50025. LAM_G_DOMAIN. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| ChiTaRS | NRXN1. mouse. |
| SOURCE | Search... |
Entry information
| Entry name | NRX1B_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P0DI97 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |