P0DI87 (OXLA_BOTIN) Reviewed, UniProtKB/Swiss-Prot
Last modified October 3, 2012. Version 6. History...
Names and origin
|Protein names||Recommended name:|
|Organism||Bothrops insularis (Golden lancehead) (Queimada jararaca)|
|Taxonomic identifier||8723 [NCBI]|
|Taxonomic lineage||Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Scleroglossa › Serpentes › Colubroidea › Viperidae › Crotalinae › Bothrops|
|Sequence length||49 AA.|
|Protein existence||Evidence at protein level|
General annotation (Comments)
Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation. Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation. These different effects are probably due to different experimental conditions By similarity. In addition, this protein induces apoptosis and necrosis and has inhibitory effects on rat kidney function (decrease of blood flow and glomerular filtration). Ref.1
An L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2.
FAD By similarity.
Homodimer; non-covalently linked By similarity.
Expressed by the venom gland. Ref.1
N-glycosylated By similarity.
Hemostasis impairing toxin
|Technical term||Direct protein sequencing|
|Gene Ontology (GO)|
Inferred from electronic annotation. Source: UniProtKB-KWcytolysis
Inferred from electronic annotation. Source: UniProtKB-KWdefense response to bacterium
Inferred from electronic annotation. Source: UniProtKB-KWhemolysis in other organism
Inferred from electronic annotation. Source: UniProtKB-KW
Inferred from electronic annotation. Source: UniProtKB-SubCell
|Molecular_function||L-amino-acid oxidase activity|
Inferred from electronic annotation. Source: EC
|Complete GO annotation...|
Sequence annotation (Features)
|||"Purification and biological effects of L-amino acid oxidase isolated from Bothrops insularis venom."|
Braga M.D., Martins A.M., Amora D.N., de Menezes D.B., Toyama M.H., Toyama D.O., Marangoni S., Alves C.D., Barbosa P.S., de Sousa Alves R., Fonteles M.C., Monteiro H.S.A.
Toxicon 51:199-207(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
|Accession||Primary (citable) accession number: P0DI87|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Chordata Protein Annotation Program|
|Annotation program||Animal Toxin Annotation Program|
Index of protein domains and families