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P0DI82

- TPC2B_HUMAN

UniProt

P0DI82 - TPC2B_HUMAN

Protein

Trafficking protein particle complex subunit 2 protein TRAPPC2P1

Gene

TRAPPC2P1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Prevents transcriptional repression and induction of cell death by ENO1. May play a role in vesicular transport from endoplasmic reticulum to Golgi.1 Publication

    GO - Biological processi

    1. ER to Golgi vesicle-mediated transport Source: InterPro
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    ER-Golgi transport, Transcription, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trafficking protein particle complex subunit 2 protein TRAPPC2P1
    Alternative name(s):
    MBP-1-interacting protein 2A
    Short name:
    MIP-2A
    Gene namesi
    Name:TRAPPC2P1
    Synonyms:SEDLP1, TRAPPC2.19
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:10710. TRAPPC2P1.

    Subcellular locationi

    Nucleus By similarity. Cytoplasmperinuclear region 1 Publication. Endoplasmic reticulum 1 Publication. Golgi apparatus 1 Publication
    Note: Localized in perinuclear granular structures.

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell
    2. Golgi apparatus Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell
    4. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 140140Trafficking protein particle complex subunit 2 protein TRAPPC2P1PRO_0000412454Add
    BLAST

    Proteomic databases

    PRIDEiP0DI82.

    Expressioni

    Tissue specificityi

    Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, fetal cartilage, fibroblasts, placenta and lymphocytes.1 Publication

    Gene expression databases

    BgeeiP0DI82.
    CleanExiHS_TRAPPC2.

    Organism-specific databases

    HPAiCAB004665.

    Interactioni

    Subunit structurei

    Interacts with PITX1, SF1, and TRAPPC3 By similarity. Can homodimerize By similarity. Part of the multisubunit TRAPP (transport protein particle) complex. Interacts with ENO1 and TRAPPC2L.By similarity3 Publications

    Protein-protein interaction databases

    BioGridi112299. 17 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP0DI82.
    SMRiP0DI82. Positions 1-140.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    OrthoDBiEOG7JQBQ9.
    PhylomeDBiP0DI82.
    TreeFamiTF314814.

    Family and domain databases

    InterProiIPR011012. Longin-like_dom.
    IPR006722. Sedlin.
    [Graphical view]
    PANTHERiPTHR12403. PTHR12403. 1 hit.
    PfamiPF04628. Sedlin_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF64356. SSF64356. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0DI82-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGSFYFVIV GHHDNPVFEM EFLPAGKAES KDDHRHLNQF IAHAALDLVD    50
    ENMWLSNNMY LKTVDKFNEW FVSAFVTAGH MRFIMLHDIR QEDGIKNFFT 100
    DVYDLYIKFS MNPFYEPNSP IRSSAFDRKV QFLGKKHLLS 140
    Length:140
    Mass (Da):16,445
    Last modified:September 21, 2011 - v1
    Checksum:iB099943C6F88952C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti105 – 1051L → P in AAG02469. (PubMed:11134351)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF291676 mRNA. Translation: AAG02469.1.
    AF058918 mRNA. Translation: AAC14421.1.
    AC003002 Genomic DNA. Translation: AAB80684.1.
    BC008889 mRNA. No translation available.
    BC032809 mRNA. No translation available.
    RefSeqiNP_001011658.1. NM_001011658.3.
    NP_055378.1. NM_014563.5.
    UniGeneiHs.446620.
    Hs.592238.
    Hs.622292.

    Genome annotation databases

    EnsembliENST00000543226; ENSP00000442778; ENSG00000256060.
    ENST00000596755; ENSP00000469888; ENSG00000256060.
    GeneIDi6399.
    KEGGihsa:6399.

    Polymorphism databases

    DMDMi347662478.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF291676 mRNA. Translation: AAG02469.1 .
    AF058918 mRNA. Translation: AAC14421.1 .
    AC003002 Genomic DNA. Translation: AAB80684.1 .
    BC008889 mRNA. No translation available.
    BC032809 mRNA. No translation available.
    RefSeqi NP_001011658.1. NM_001011658.3.
    NP_055378.1. NM_014563.5.
    UniGenei Hs.446620.
    Hs.592238.
    Hs.622292.

    3D structure databases

    ProteinModelPortali P0DI82.
    SMRi P0DI82. Positions 1-140.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112299. 17 interactions.

    Polymorphism databases

    DMDMi 347662478.

    Proteomic databases

    PRIDEi P0DI82.

    Protocols and materials databases

    DNASUi 6399.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000543226 ; ENSP00000442778 ; ENSG00000256060 .
    ENST00000596755 ; ENSP00000469888 ; ENSG00000256060 .
    GeneIDi 6399.
    KEGGi hsa:6399.

    Organism-specific databases

    CTDi 6399.
    GeneCardsi GC19P057874.
    HGNCi HGNC:10710. TRAPPC2P1.
    HPAi CAB004665.
    neXtProti NX_P0DI82.
    GenAtlasi Search...

    Phylogenomic databases

    OrthoDBi EOG7JQBQ9.
    PhylomeDBi P0DI82.
    TreeFami TF314814.

    Miscellaneous databases

    GenomeRNAii 6399.
    NextBioi 24860.
    PROi P0DI82.

    Gene expression databases

    Bgeei P0DI82.
    CleanExi HS_TRAPPC2.

    Family and domain databases

    InterProi IPR011012. Longin-like_dom.
    IPR006722. Sedlin.
    [Graphical view ]
    PANTHERi PTHR12403. PTHR12403. 1 hit.
    Pfami PF04628. Sedlin_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64356. SSF64356. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1."
      Ghosh A.K., Majumder M., Steele R., White R.A., Ray R.B.
      Mol. Cell. Biol. 21:655-662(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH ENO1, SUBCELLULAR LOCATION.
    2. "Human cDNA complete cds homolog to yeast protein P38334."
      Hu G.
      Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Lung carcinoma.
    5. "Identification of the gene (SEDL) causing X-linked spondyloepiphyseal dysplasia tarda."
      Gedeon A.K., Colley A., Jamieson R., Thompson E.M., Rogers J., Sillence D., Tiller G.E., Mulley J.C., Gecz J.
      Nat. Genet. 22:400-404(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. "Gene structure and expression study of the SEDL gene for spondyloepiphyseal dysplasia tarda."
      Gecz J., Hillman M.A., Gedeon A.K., Cox T.C., Baker E., Mulley J.C.
      Genomics 69:242-251(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOMIC ORGANIZATION.
    7. Cited for: IDENTIFICATION IN TRAPP COMPLEX.
    8. "TRAPPC2L is a novel, highly conserved TRAPP-interacting protein."
      Scrivens P.J., Shahrzad N., Moores A., Morin A., Brunet S., Sacher M.
      Traffic 10:724-736(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN TRAPP COMPLEX, INTERACTION WITH TRAPPC2L.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTPC2B_HUMAN
    AccessioniPrimary (citable) accession number: P0DI82
    Secondary accession number(s): A6NEG0, O14582, Q9HD16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The gene encoding this protein appears to have arisen by retrotransposition of a cDNA from the X-linked locus TRAPPC2. The site of integration of this retrotransposed cDNA appears to lie within an intron of the ZNF547 gene, which provides a promoter and non-coding 5' exon. TRAPPC2 and this protein are indistinguishable at protein level, and both proteins have been identified and functionally characterized.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3