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Protein

Trafficking protein particle complex subunit 2 protein TRAPPC2P1

Gene

TRAPPC2P1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Prevents transcriptional repression and induction of cell death by ENO1. May play a role in vesicular transport from endoplasmic reticulum to Golgi.1 Publication

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: InterPro
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transcription, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 2 protein TRAPPC2P1
Alternative name(s):
MBP-1-interacting protein 2A
Short name:
MIP-2A
Gene namesi
Name:TRAPPC2P1
Synonyms:SEDLP1, TRAPPC2.19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:10710. TRAPPC2P1.

Subcellular locationi

Nucleus By similarity. Cytoplasmperinuclear region 1 Publication. Endoplasmic reticulum 1 Publication. Golgi apparatus 1 Publication
Note: Localized in perinuclear granular structures.

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-SubCell
  2. Golgi apparatus Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
  4. perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Trafficking protein particle complex subunit 2 protein TRAPPC2P1PRO_0000412454Add
BLAST

Proteomic databases

PRIDEiP0DI82.

Expressioni

Tissue specificityi

Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, fetal cartilage, fibroblasts, placenta and lymphocytes.1 Publication

Gene expression databases

BgeeiP0DI82.
CleanExiHS_TRAPPC2.
ExpressionAtlasiP0DI82. baseline and differential.

Interactioni

Subunit structurei

Interacts with PITX1, SF1, and TRAPPC3 (By similarity). Can homodimerize (By similarity). Part of the multisubunit TRAPP (transport protein particle) complex. Interacts with ENO1 and TRAPPC2L.By similarity3 Publications

Protein-protein interaction databases

BioGridi112299. 22 interactions.

Structurei

3D structure databases

ProteinModelPortaliP0DI82.
SMRiP0DI82. Positions 1-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiP0DI82.
OrthoDBiEOG7JQBQ9.
PhylomeDBiP0DI82.
TreeFamiTF314814.

Family and domain databases

InterProiIPR011012. Longin-like_dom.
IPR006722. Sedlin.
[Graphical view]
PANTHERiPTHR12403. PTHR12403. 1 hit.
PfamiPF04628. Sedlin_N. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.

Sequencei

Sequence statusi: Complete.

P0DI82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSFYFVIV GHHDNPVFEM EFLPAGKAES KDDHRHLNQF IAHAALDLVD
60 70 80 90 100
ENMWLSNNMY LKTVDKFNEW FVSAFVTAGH MRFIMLHDIR QEDGIKNFFT
110 120 130 140
DVYDLYIKFS MNPFYEPNSP IRSSAFDRKV QFLGKKHLLS
Length:140
Mass (Da):16,445
Last modified:September 21, 2011 - v1
Checksum:iB099943C6F88952C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051L → P in AAG02469 (PubMed:11134351).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291676 mRNA. Translation: AAG02469.1.
AF058918 mRNA. Translation: AAC14421.1.
AC003002 Genomic DNA. Translation: AAB80684.1.
BC008889 mRNA. No translation available.
BC032809 mRNA. No translation available.
RefSeqiNP_001011658.1. NM_001011658.3.
NP_055378.1. NM_014563.5.
UniGeneiHs.446620.
Hs.592238.
Hs.622292.

Genome annotation databases

EnsembliENST00000543226; ENSP00000442778; ENSG00000256060.
ENST00000596755; ENSP00000469888; ENSG00000256060.
GeneIDi6399.
KEGGihsa:6399.

Polymorphism databases

DMDMi347662478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291676 mRNA. Translation: AAG02469.1.
AF058918 mRNA. Translation: AAC14421.1.
AC003002 Genomic DNA. Translation: AAB80684.1.
BC008889 mRNA. No translation available.
BC032809 mRNA. No translation available.
RefSeqiNP_001011658.1. NM_001011658.3.
NP_055378.1. NM_014563.5.
UniGeneiHs.446620.
Hs.592238.
Hs.622292.

3D structure databases

ProteinModelPortaliP0DI82.
SMRiP0DI82. Positions 1-140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112299. 22 interactions.

Polymorphism databases

DMDMi347662478.

Proteomic databases

PRIDEiP0DI82.

Protocols and materials databases

DNASUi6399.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000543226; ENSP00000442778; ENSG00000256060.
ENST00000596755; ENSP00000469888; ENSG00000256060.
GeneIDi6399.
KEGGihsa:6399.

Organism-specific databases

CTDi6399.
GeneCardsiGC19P057874.
HGNCiHGNC:10710. TRAPPC2P1.
neXtProtiNX_P0DI82.
GenAtlasiSearch...

Phylogenomic databases

InParanoidiP0DI82.
OrthoDBiEOG7JQBQ9.
PhylomeDBiP0DI82.
TreeFamiTF314814.

Miscellaneous databases

GenomeRNAii6399.
NextBioi24860.
PROiP0DI82.

Gene expression databases

BgeeiP0DI82.
CleanExiHS_TRAPPC2.
ExpressionAtlasiP0DI82. baseline and differential.

Family and domain databases

InterProiIPR011012. Longin-like_dom.
IPR006722. Sedlin.
[Graphical view]
PANTHERiPTHR12403. PTHR12403. 1 hit.
PfamiPF04628. Sedlin_N. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1."
    Ghosh A.K., Majumder M., Steele R., White R.A., Ray R.B.
    Mol. Cell. Biol. 21:655-662(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH ENO1, SUBCELLULAR LOCATION.
  2. "Human cDNA complete cds homolog to yeast protein P38334."
    Hu G.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Lung carcinoma.
  5. "Identification of the gene (SEDL) causing X-linked spondyloepiphyseal dysplasia tarda."
    Gedeon A.K., Colley A., Jamieson R., Thompson E.M., Rogers J., Sillence D., Tiller G.E., Mulley J.C., Gecz J.
    Nat. Genet. 22:400-404(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "Gene structure and expression study of the SEDL gene for spondyloepiphyseal dysplasia tarda."
    Gecz J., Hillman M.A., Gedeon A.K., Cox T.C., Baker E., Mulley J.C.
    Genomics 69:242-251(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOMIC ORGANIZATION.
  7. Cited for: IDENTIFICATION IN TRAPP COMPLEX.
  8. "TRAPPC2L is a novel, highly conserved TRAPP-interacting protein."
    Scrivens P.J., Shahrzad N., Moores A., Morin A., Brunet S., Sacher M.
    Traffic 10:724-736(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN TRAPP COMPLEX, INTERACTION WITH TRAPPC2L.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTPC2B_HUMAN
AccessioniPrimary (citable) accession number: P0DI82
Secondary accession number(s): A6NEG0, O14582, Q9HD16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: September 21, 2011
Last modified: March 4, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gene encoding this protein appears to have arisen by retrotransposition of a cDNA from the X-linked locus TRAPPC2. The site of integration of this retrotransposed cDNA appears to lie within an intron of the ZNF547 gene, which provides a promoter and non-coding 5' exon. TRAPPC2 and this protein are indistinguishable at protein level, and both proteins have been identified and functionally characterized.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.