P0DI82 (TPC2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trafficking protein particle complex subunit 2 protein TRAPPC2P1

Alternative name(s):
MBP-1-interacting protein 2A
Short name=MIP-2A

Gene names

Name:	TRAPPC2P1
Synonyms:	SEDLP1, TRAPPC2.19

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	140 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Prevents transcriptional repression and induction of cell death by ENO1. May play a role in vesicular transport from endoplasmic reticulum to Golgi. Ref.1
Subunit structure	Interacts with PITX1, SF1, and TRAPPC3 By similarity. Can homodimerize By similarity. Part of the multisubunit TRAPP (transport protein particle) complex. Interacts with ENO1 and TRAPPC2L. Ref.1 Ref.7 Ref.8
Subcellular location	Nucleus By similarity. Cytoplasm › perinuclear region. Endoplasmic reticulum. Golgi apparatus. Note: Localized in perinuclear granular structures. Ref.1
Tissue specificity	Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, fetal cartilage, fibroblasts, placenta and lymphocytes. Ref.5
Miscellaneous	The gene encoding this protein appears to have arisen by retrotransposition of a cDNA from the X-linked locus TRAPPC2. The site of integration of this retrotransposed cDNA appears to lie within an intron of the ZNF547 gene, which provides a promoter and non-coding 5' exon. TRAPPC2 and this protein are indistinguishable at protein level, and both proteins have been identified and functionally characterized.
Sequence similarities	Belongs to the TRAPP small subunits family. Sedlin subfamily.

Ontologies

Keywords
Biological process	ER-Golgi transport Transcription Transport
Cellular component	Cytoplasm Endoplasmic reticulum Golgi apparatus Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ER to Golgi vesicle-mediated transport Inferred from electronic annotation. Source: InterPro transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 140	140	Trafficking protein particle complex subunit 2 protein TRAPPC2P1		PRO_0000412454
Experimental info
	Sequence conflict	105	1	L → P in AAG02469. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P0DI82 [UniParc]. Last modified September 21, 2011. Version 1. Checksum: B099943C6F88952C	FASTA	140	16,445
	10 20 30 40 50 60 MSGSFYFVIV GHHDNPVFEM EFLPAGKAES KDDHRHLNQF IAHAALDLVD ENMWLSNNMY 70 80 90 100 110 120 LKTVDKFNEW FVSAFVTAGH MRFIMLHDIR QEDGIKNFFT DVYDLYIKFS MNPFYEPNSP 130 140 IRSSAFDRKV QFLGKKHLLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1." Ghosh A.K., Majumder M., Steele R., White R.A., Ray R.B. Mol. Cell. Biol. 21:655-662(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH ENO1, SUBCELLULAR LOCATION.
[2]	"Human cDNA complete cds homolog to yeast protein P38334." Hu G. Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Lung carcinoma.
[5]	"Identification of the gene (SEDL) causing X-linked spondyloepiphyseal dysplasia tarda." Gedeon A.K., Colley A., Jamieson R., Thompson E.M., Rogers J., Sillence D., Tiller G.E., Mulley J.C., Gecz J. Nat. Genet. 22:400-404(1999) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[6]	"Gene structure and expression study of the SEDL gene for spondyloepiphyseal dysplasia tarda." Gecz J., Hillman M.A., Gedeon A.K., Cox T.C., Baker E., Mulley J.C. Genomics 69:242-251(2000) [PubMed] [Europe PMC] [Abstract] Cited for: GENOMIC ORGANIZATION.
[7]	"Functional organization of the yeast proteome by systematic analysis of protein complexes." Gavin A.-C., Boesche M., Krause R., Grandi P., Marzioch M., Bauer A., Schultz J., Rick J.M., Michon A.-M., Cruciat C.-M., Remor M., Hoefert C., Schelder M., Brajenovic M., Ruffner H., Merino A., Klein K., Hudak M. , Dickson D., Rudi T., Gnau V., Bauch A., Bastuck S., Huhse B., Leutwein C., Heurtier M.-A., Copley R.R., Edelmann A., Querfurth E., Rybin V., Drewes G., Raida M., Bouwmeester T., Bork P., Seraphin B., Kuster B., Neubauer G., Superti-Furga G. Nature 415:141-147(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN TRAPP COMPLEX.
[8]	"TRAPPC2L is a novel, highly conserved TRAPP-interacting protein." Scrivens P.J., Shahrzad N., Moores A., Morin A., Brunet S., Sacher M. Traffic 10:724-736(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN TRAPP COMPLEX, INTERACTION WITH TRAPPC2L.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF291676 mRNA. Translation: AAG02469.1. AF058918 mRNA. Translation: AAC14421.1. AC003002 Genomic DNA. Translation: AAB80684.1. BC008889 mRNA. No translation available. BC032809 mRNA. No translation available.
IPI	IPI00005119.
RefSeq	NP_001011658.1. NM_001011658.3. NP_055378.1. NM_014563.5.
UniGene	Hs.446620. Hs.592238. Hs.622292.
3D structure databases
ProteinModelPortal	P0DI82.
ModBase	Search...
Proteomic databases
PRIDE	P0DI82.
Protocols and materials databases
DNASU	6399.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000543226; ENSP00000442778; ENSG00000256060. ENST00000596755; ENSP00000469888; ENSG00000256060.
GeneID	6399.
KEGG	hsa:6399.
Organism-specific databases
CTD	6399.
GeneCards	GC19P057874.
HGNC	HGNC:10710. TRAPPC2P1.
HPA	CAB004665.
neXtProt	NX_P0DI82.
GenAtlas	Search...
Gene expression databases
ArrayExpress	P0DI82.
Bgee	P0DI82.
CleanEx	HS_TRAPPC2.
Family and domain databases
InterPro	IPR011012. Longin-like_dom. IPR006722. Sedlin. [Graphical view]
PANTHER	PTHR12403. PTHR12403. 1 hit.
Pfam	PF04628. Sedlin_N. 1 hit. [Graphical view]
SUPFAM	SSF64356. Longin_like. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	6399.
NextBio	24860.

Entry information

Entry name

TPC2B_HUMAN

Accession

Primary (citable) accession number: P0DI82
Secondary accession number(s): A6NEG0, O14582, Q9HD16

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 21, 2011
Last sequence update:	September 21, 2011
Last modified:	May 1, 2013
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.