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P0DI82 (TPC2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trafficking protein particle complex subunit 2 protein TRAPPC2P1
Alternative name(s):
MBP-1-interacting protein 2A
Short name=MIP-2A
Gene names
Name:TRAPPC2P1
Synonyms:SEDLP1, TRAPPC2.19
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length140 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Prevents transcriptional repression and induction of cell death by ENO1. May play a role in vesicular transport from endoplasmic reticulum to Golgi. Ref.1

Subunit structure

Interacts with PITX1, SF1, and TRAPPC3 By similarity. Can homodimerize By similarity. Part of the multisubunit TRAPP (transport protein particle) complex. Interacts with ENO1 and TRAPPC2L. Ref.1 Ref.7 Ref.8

Subcellular location

Nucleus By similarity. Cytoplasmperinuclear region. Endoplasmic reticulum. Golgi apparatus. Note: Localized in perinuclear granular structures. Ref.1

Tissue specificity

Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, fetal cartilage, fibroblasts, placenta and lymphocytes. Ref.5

Miscellaneous

The gene encoding this protein appears to have arisen by retrotransposition of a cDNA from the X-linked locus TRAPPC2. The site of integration of this retrotransposed cDNA appears to lie within an intron of the ZNF547 gene, which provides a promoter and non-coding 5' exon. TRAPPC2 and this protein are indistinguishable at protein level, and both proteins have been identified and functionally characterized.

Sequence similarities

Belongs to the TRAPP small subunits family. Sedlin subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 140140Trafficking protein particle complex subunit 2 protein TRAPPC2P1
PRO_0000412454

Experimental info

Sequence conflict1051L → P in AAG02469. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P0DI82 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: B099943C6F88952C

FASTA14016,445
        10         20         30         40         50         60 
MSGSFYFVIV GHHDNPVFEM EFLPAGKAES KDDHRHLNQF IAHAALDLVD ENMWLSNNMY 

        70         80         90        100        110        120 
LKTVDKFNEW FVSAFVTAGH MRFIMLHDIR QEDGIKNFFT DVYDLYIKFS MNPFYEPNSP 

       130        140 
IRSSAFDRKV QFLGKKHLLS 

« Hide

References

« Hide 'large scale' references
[1]"A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1."
Ghosh A.K., Majumder M., Steele R., White R.A., Ray R.B.
Mol. Cell. Biol. 21:655-662(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH ENO1, SUBCELLULAR LOCATION.
[2]"Human cDNA complete cds homolog to yeast protein P38334."
Hu G.
Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Lung carcinoma.
[5]"Identification of the gene (SEDL) causing X-linked spondyloepiphyseal dysplasia tarda."
Gedeon A.K., Colley A., Jamieson R., Thompson E.M., Rogers J., Sillence D., Tiller G.E., Mulley J.C., Gecz J.
Nat. Genet. 22:400-404(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[6]"Gene structure and expression study of the SEDL gene for spondyloepiphyseal dysplasia tarda."
Gecz J., Hillman M.A., Gedeon A.K., Cox T.C., Baker E., Mulley J.C.
Genomics 69:242-251(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOMIC ORGANIZATION.
[7]"Functional organization of the yeast proteome by systematic analysis of protein complexes."
Gavin A.-C., Boesche M., Krause R., Grandi P., Marzioch M., Bauer A., Schultz J., Rick J.M., Michon A.-M., Cruciat C.-M., Remor M., Hoefert C., Schelder M., Brajenovic M., Ruffner H., Merino A., Klein K., Hudak M. expand/collapse author list , Dickson D., Rudi T., Gnau V., Bauch A., Bastuck S., Huhse B., Leutwein C., Heurtier M.-A., Copley R.R., Edelmann A., Querfurth E., Rybin V., Drewes G., Raida M., Bouwmeester T., Bork P., Seraphin B., Kuster B., Neubauer G., Superti-Furga G.
Nature 415:141-147(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN TRAPP COMPLEX.
[8]"TRAPPC2L is a novel, highly conserved TRAPP-interacting protein."
Scrivens P.J., Shahrzad N., Moores A., Morin A., Brunet S., Sacher M.
Traffic 10:724-736(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN TRAPP COMPLEX, INTERACTION WITH TRAPPC2L.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF291676 mRNA. Translation: AAG02469.1.
AF058918 mRNA. Translation: AAC14421.1.
AC003002 Genomic DNA. Translation: AAB80684.1.
BC008889 mRNA. No translation available.
BC032809 mRNA. No translation available.
RefSeqNP_001011658.1. NM_001011658.3.
NP_055378.1. NM_014563.5.
UniGeneHs.446620.
Hs.592238.
Hs.622292.

3D structure databases

ProteinModelPortalP0DI82.
SMRP0DI82. Positions 1-140.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112299. 17 interactions.

Polymorphism databases

DMDM347662478.

Proteomic databases

PRIDEP0DI82.

Protocols and materials databases

DNASU6399.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000543226; ENSP00000442778; ENSG00000256060.
ENST00000596755; ENSP00000469888; ENSG00000256060.
GeneID6399.
KEGGhsa:6399.

Organism-specific databases

CTD6399.
GeneCardsGC19P057874.
HGNCHGNC:10710. TRAPPC2P1.
HPACAB004665.
neXtProtNX_P0DI82.
GenAtlasSearch...

Phylogenomic databases

OrthoDBEOG7JQBQ9.
PhylomeDBP0DI82.
TreeFamTF314814.

Gene expression databases

BgeeP0DI82.
CleanExHS_TRAPPC2.

Family and domain databases

InterProIPR011012. Longin-like_dom.
IPR006722. Sedlin.
[Graphical view]
PANTHERPTHR12403. PTHR12403. 1 hit.
PfamPF04628. Sedlin_N. 1 hit.
[Graphical view]
SUPFAMSSF64356. SSF64356. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi6399.
NextBio24860.
PROP0DI82.

Entry information

Entry nameTPC2B_HUMAN
AccessionPrimary (citable) accession number: P0DI82
Secondary accession number(s): A6NEG0, O14582, Q9HD16
Entry history
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: September 21, 2011
Last modified: April 16, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM