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Protein

Peroxidase 1

Gene

PER1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei62Transition state stabilizerPROSITE-ProRule annotation1
Active sitei66Proton acceptorPROSITE-ProRule annotation1
Metal bindingi67Calcium 1PROSITE-ProRule annotation1
Metal bindingi70Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi72Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi74Calcium 1PROSITE-ProRule annotation1
Metal bindingi76Calcium 1PROSITE-ProRule annotation1
Binding sitei161Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi191Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi192Calcium 2PROSITE-ProRule annotation1
Metal bindingi242Calcium 2PROSITE-ProRule annotation1
Metal bindingi245Calcium 2PROSITE-ProRule annotation1
Metal bindingi250Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei77. AtPrx01.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 1 (EC:1.11.1.7)
Alternative name(s):
ATP11a
Atperox P1
Gene namesi
Name:PER1
Synonyms:P1
Ordered Locus Names:At1g05240
ORF Names:YUP8H12.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G05240.
TAIRilocus:2817952. AT1G05240.

Subcellular locationi

  • Secreted PROSITE-ProRule annotation

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • plant-type cell wall Source: TAIR
  • plasmodesma Source: TAIR

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002366822 – 325Peroxidase 1Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 113PROSITE-ProRule annotation
Disulfide bondi68 ↔ 73PROSITE-ProRule annotation
Disulfide bondi119 ↔ 321PROSITE-ProRule annotation
Disulfide bondi198 ↔ 230PROSITE-ProRule annotation
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP0DI10.
PRIDEiP0DI10.

Expressioni

Tissue specificityi

Slightly expressed in roots.

Inductioni

Up-regulated transiently by a cold treatment.1 Publication

Gene expression databases

GenevisibleiP0DI10. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G05250.1.

Structurei

3D structure databases

ProteinModelPortaliP0DI10.
SMRiP0DI10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFQR. Eukaryota.
ENOG410Y9ME. LUCA.
InParanoidiP0DI10.
KOiK00430.
OMAiGLINNRI.
OrthoDBiEOG09360FKB.
PhylomeDBiP0DI10.

Family and domain databases

CDDicd00693. secretory_peroxidase. 1 hit.
InterProiView protein in InterPro
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR000823. Peroxidase_pln.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
IPR033905. Secretory_peroxidase.
PfamiView protein in Pfam
PF00141. peroxidase. 1 hit.
PRINTSiPR00458. PEROXIDASE.
PR00461. PLPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiView protein in PROSITE
PS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DI10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIKNILALV VLLSVVGVSV AIPQLLDLDY YRSKCPKAEE IVRGVTVQYV
60 70 80 90 100
SRQKTLAAKL LRMHFHDCFV RGCDGSVLLK SAKNDAERDA VPNLTLKGYE
110 120 130 140 150
VVDAAKTALE RKCPNLISCA DVLALVARDA VAVIGGPWWP VPLGRRDGRI
160 170 180 190 200
SKLNDALLNL PSPFADIKTL KKNFANKGLN AKDLVVLSGG HTIGISSCAL
210 220 230 240 250
VNSRLYNFTG KGDSDPSMNP SYVRELKRKC PPTDFRTSLN MDPGSALTFD
260 270 280 290 300
THYFKVVAQK KGLFTSDSTL LDDIETKNYV QTQAILPPVF SSFNKDFSDS
310 320
MVKLGFVQIL TGKNGEIRKR CAFPN
Length:325
Mass (Da):35,624
Last modified:April 18, 2012 - v1
Checksum:i0D6D7DBDBBFC264E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98802 mRNA. Translation: CAA67334.1.
AC000098 Genomic DNA. Translation: AAB71454.1.
CP002684 Genomic DNA. Translation: AEE27813.1.
AY123989 mRNA. Translation: AAM74501.1.
BT000584 mRNA. Translation: AAN18153.1.
PIRiA86187.
RefSeqiNP_563732.1. NM_100403.4.
NP_563733.1. NM_100404.4.
UniGeneiAt.139.
At.73045.

Genome annotation databases

EnsemblPlantsiAT1G05240.1; AT1G05240.1; AT1G05240.
AT1G05250.1; AT1G05250.1; AT1G05250.
GeneIDi838206.
839237.
GrameneiAT1G05240.1; AT1G05240.1; AT1G05240.
AT1G05250.1; AT1G05250.1; AT1G05250.
KEGGiath:AT1G05240.
ath:AT1G05250.

Similar proteinsi

Entry informationi

Entry nameiPER1_ARATH
AccessioniPrimary (citable) accession number: P0DI10
Secondary accession number(s): Q96506
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: April 18, 2012
Last modified: June 7, 2017
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families